Mixed mode data collection designs are increasingly being adopted with the hope that they may reduce selection errors in single mode survey designs. Yet possible reductions in selection errors achieved by mixing modes may be offset by a potential increase in total survey error due to extra measurement error being introduced by the additional mode(s). Few studies have investigated this empirically, however. In the present study, we compute the Mean Squared Error (MSE) for a range of estimates using data from a mode comparison experiment. We compare two mixed mode designs (a sequential web plus mail survey, and a combined concurrent and sequential CATI plus mail survey) with a single mode mail survey. The availability of auxiliary data on the sampling frame allows us to estimate several components of MSE (sampling variance, non-coverage, nonresponse and measurement bias) for a number of sociodemographic and target variables. Overall, MSEs are lowest for the single mode survey, and highest for the CATI plus mail design, though this pattern is not consistent across all estimates. Mixing modes generally reduces total bias, but the relative contribution to total survey error from different sources varies by design and by variable type.