Social Disparities in Lung Cancer Risk and Screening

Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress–related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms and the risk of lung cancer.Methods: Six single-nucleotide polymorphisms (SNPs) of EIF2AK3, HSPA5, and DDIT3 were genotyped in 620 cases and 620 controls using a MassARRAY platform.Results: The minor allele A of rs6750998 was a protective allele against the risk of lung cancer (p < 0.001), while the minor alleles of rs867529, rs391957, and rs697221 were all risk alleles that may lead to multiplied risk of the disease (rprs867529 = 0.002; prs391957 = 0.015; prs697221 < 0.001). Moreover, the rs6750998-TA/AA genotypes were protective genotypes against the risk of lung cancer (p = 0.005); however, the rs867529-GC/CC, rs391957-CC, and rs697221-GA/AA genotypes were associated with elevated lung cancer risk (prs867529 = 0.003, prs391957 = 0.028, and prs697221 = 0.0001). In addition, EIF2AK3-rs6750998 was associated with a decreased risk of lung cancer under dominant, recessive, and log-additive models (p < 0.05). By contrast, the EIF2AK3-rs867529 was correlated with an increased risk of the disease under dominant and log-additive models (p = 0.001). Moreover, HSPA5-rs391957 was related to an elevated risk of the disease under recessive and log-additive models (p < 0.02). DDIT3-rs697221 was identified to have a significant association with the risk of lung cancer under all three genetic models (p < 0.01).Conclusion: Our results provide new insights on the role of the ER stress–related genes EIF2AK3, HSPA5, and DDIT3 polymorphisms for lung cancer risk.

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“…Tobacco use is an important risk factor for lung cancer ( Raman et al, 2022 ). We performed a stratified analysis based on smoking status.…”

Section: Discussionmentioning

confidence: 99%

ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer

et al. 2022

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“…54 While these criteria were designed to ensure high-quality screening practices, they also present significant logistic hurdles for the implementation of lung cancer screening programs, which could heighten disparities in areas already underserved by the healthcare system. 55 Further difficulty accessing lung cancer screening may result from the fact that coverage for Medicaid patients is determined at the state level. In states without Medicaid expansion, lung cancer screening is not required to be covered.…”

Section: Lung Cancer Screeningmentioning

confidence: 99%

Disparities in thoracic surgical oncology

Williams

McAllister

Erkmen

et al. 2023

Journal of Surgical Oncology

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Disparities in access and outcomes of thoracic surgical oncology are long standing. This article examines the patient, population, and systems‐level factors that contribute to these disparities and inequities. The need for research and policy to identify and solve these problems is apparent. As leaders in the field of thoracic oncology, surgeons will be instrumental in narrowing these gaps and moving the discipline forward.

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“…In some lung cancer patients with no smoking history, the disease can be attributed to exposure to radon ( 222 Rn), usually from building materials ( 4 ). The incidence of lung cancer is also related to genetics and demographic characteristics ( 5 ). The link with demographic characteristics may be attributable to differences in health care systems in different countries.…”

Section: Introductionmentioning

confidence: 99%

Current treatments for non-small cell lung cancer

et al. 2022

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Despite improved methods of diagnosis and the development of different treatments, mortality from lung cancer remains surprisingly high. Non-small cell lung cancer (NSCLC) accounts for the large majority of lung cancer cases. Therefore, it is important to review current methods of diagnosis and treatments of NSCLC in the clinic and preclinic. In this review, we describe, as a guide for clinicians, current diagnostic methods and therapies (such as chemotherapy, chemoradiotherapy, targeted therapy, antiangiogenic therapy, immunotherapy, and combination therapy) for NSCLC.

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Social Disparities in Lung Cancer Risk and Screening

Cited by 23 publications

References 61 publications

ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer

ER Stress–Related Genes EIF2AK3, HSPA5, and DDIT3 Polymorphisms are Associated With Risk of Lung Cancer

Disparities in thoracic surgical oncology

Current treatments for non-small cell lung cancer

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