Social Dominance and Immunity in Animals

Kennedy, Sarah M.

doi:10.1016/b978-012088576-3/50028-9

Cited by 5 publications

(4 citation statements)

References 136 publications

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“…Hence, the stressors associated with the presence of female mice may have also led to increases in gonadal steroids in males. The observed intra-strain variation in larval burdens may be a result of differing responses to an environmental challenge, influenced by social organization (Laudenslager and Kennedy, 2008). Infection in dominance hierarchies has been documented previously in response to the protozoan Babesia microti (Barnard et al 1994), but data on dominance were not collected in the current work.…”

Section: Discussioncontrasting

confidence: 40%

The role of Intelectin-2 in resistance toAscaris suumlung larval burdens in susceptible and resistant mouse strains

et al. 2011

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SUMMARYThe underlying mechanism of predisposition toAscarisinfection is not yet understood but host genetics are thought to play a fundamental role. We investigated the association between the Intelectin-2 gene and resistance in F2mice derived from mouse strains known to be susceptible and resistant to infection.Ascarislarvae were isolated from murine lungs and the number of copies of the Intelectin-2 gene was determined in F2mice. Intelectin-2 gene copy number was not significantly linked to larval burden. In a pilot experiment, the response to infection in parental mice of both sexes was observed in order to address the suitablity of female F2mice. No overall significant sex effect was detected. However, a divergence in resistance/susceptibility status was observed between male and, female hybrid offspring. The responsiveness toAscarisin mice is likely to be controlled by multiple genes and, despite a unique absence from the susceptible C57BL/6j strain, the Intelectin-2 gene does not play a significant role in resistance. The observed intra-strain variation in larval burden requires further investigation but we hypothesize that it stems from social/dominance hierarchies created by the presence of female mice and possibly subsequent hormonal perturbations that modify the intensity of the immune response.

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Section: Discussioncontrasting

confidence: 40%

The role of Intelectin-2 in resistance toAscaris suumlung larval burdens in susceptible and resistant mouse strains

et al. 2011

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“…Hair cortisol was significantly higher in the ATYPICAL males compared to the TYPICAL males after entering time since group introduction as a covariate [F(1,7) = 8.350, p = .023] (Table 1). Although it did not reach statistical significance, hair cortisol was positively correlated with aggression (r = .49) and submissions (r = .64) and negatively correlated with grooming (r=−.46) during the two weeks after transition to new groups in directions expected by greater HPA activation associated with these behaviors (Laudenslager & Kennedy, 2007), that is, higher cortisol was associated with agonistic behaviors and lower cortisol with grooming.…”

Section: Resultsmentioning

confidence: 96%

The influences of perinatal challenge persist into the adolescent period in socially housed bonnet macaques (Macaca radiata)

Natvig

Corcoran

Blevins

et al. 2012

Developmental Psychobiology

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Social challenges during the perinatal period influence the mother-infant relationship in nonhuman primates and may affect the offspring's response to later social challenge(s). Relocation of a breeding colony of monkeys (Macaca radiata) created two groups of infants: one group experienced social group relocation to a new housing facility during the perinatal period (ATYPICAL) and the second group developed within a constant environment (TYPICAL). At a mean age of 25 mo., all animals were removed from their natal group and placed in same sex adolescent social groups. Behavioral observations were collected after group formation or introduction to a new group. ATYPICAL subjects showed increased aggression and reduced affiliation compared to TYPICAL subjects. Hair cortisol in male subjects collected 6 months after introduction was elevated in the ATYPICAL subjects compared to TYPICAL subjects. These findings demonstrate that early life challenges affect behavior as well as stress hormone responses to social challenge in adolescence.

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“…An adequate animal model includes a number of stipulations for supporting their relevancy: common etiology, phenomenology, pathophysiology, and efficacious interventions for the human condition they seek to model (Laudenslager, Boccia, & Reite, 1993). Nonhuman primates (NHPs) represented a socially complex species which afforded a number of advantages for investigating the relationship of social behaviors, not just stressor exposure, to immune regulation from both developmental and other perspectives (Coe & Laudenslager, 2007; Laudenslager & Kennedy, 2007). NHPs characterize a complex social organization that parallels humans and human society (Cirulli et al, 2009).…”

Section: Animal Modelsmentioning

confidence: 99%

“Anatomy of an Illness”: Control from a caregiver’s perspective

Laudenslager

2014

Brain, Behavior, and Immunity

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Caregivers of loved ones with chronic illnesses experience an uncontrollable challenge with potentially negative behavioral and medical consequences. Extensive research has demonstrated immune and endocrine regulation can be significantly disrupted by negative behavioral factors based on both animal models and human studies. However, fewer studies have focused on how psychosocial interventions might reverse the negative consequences of stressors such as caregiving. The distress of caring for individuals with cancer has only recently begun to receive attention. These interventions addressing caregiver distress are rare overall and caregivers of patients receiving hematopoietic stem cell transplants (HSCT) have received even less attention. HSCT caregivers report feelings of loss of control. Animal studies suggest that control over aversive events can mitigate the negative consequences of stressors. Caregivers of allogeneic HSCT patients for blood cancers must be available 24/7 for three months or longer following stem cell infusion to closely monitor the recipients’ health and well-being. Does establishing a greater sense of control have positive impacts on caregivers? A randomized control trial of a cognitive behavioral stress management intervention for allogeneic HSCT caregivers is briefly described. A model of caregiver mental health which may potentially impact the patient’s quality of life is proposed. These relationships exist in a complex system that includes genetic influences, sex, social environment, and prior experience. This system fits well within recent formulations of a “complexity science” approach to health and well-being.

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Social Dominance and Immunity in Animals

Cited by 5 publications

References 136 publications

The role of Intelectin-2 in resistance toAscaris suumlung larval burdens in susceptible and resistant mouse strains

The role of Intelectin-2 in resistance toAscaris suumlung larval burdens in susceptible and resistant mouse strains

The influences of perinatal challenge persist into the adolescent period in socially housed bonnet macaques (Macaca radiata)

“Anatomy of an Illness”: Control from a caregiver’s perspective

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