Social‐ecological theory, substance misuse, adverse childhood experiences, and adolescent suicidal ideation: Applications for community–academic partnerships

Aytur, Semra; Carlino, None Sydney; Bernard, Felicity; West, Kelsi; Dobrzycki, Victoria; Malik, Riana

doi:10.1002/jcop.22560

Cited by 20 publications

(12 citation statements)

References 46 publications

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“…In childhood and adolescence, ELS is not only associated with the heightened risk of adverse health problems [26][27][28][29][30][31][32], including physical illnesses such as headache [33] and asthma [34] but also mental illnesses such as depression, non-suicidal self-injury (NSSI) [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. A meta-analysis that examined the association between ELS and depression in adolescents found that the association between childhood abuse/neglect and depression was much stronger in adolescents than in adults [50].…”

Section: Introductionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.

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Section: Introductionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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“…Past researchers using data from the YRBS have reported that suicidality in high school students is associated with female sex ( 2 , 4 ), sexual minority status ( 47 – 49 ), adverse childhood experiences ( 50 , 51 ), physical teen dating violence ( 52 ), forced sexual intercourse ( 18 , 53 ), body weight perceptions [both overweight ( 54 , 55 ) and underweight ( 55 )], illicit drug use ( 13 , 18 ), prescription opioid misuse ( 56 – 58 ) [especially in girls ( 59 )], alcohol use ( 15 , 18 , 60 , 61 ), marijuana use ( 13 , 15 , 62 ), bullying ( 18 , 55 , 63 , 64 ) and cyberbullying ( 18 , 55 , 63 – 65 ), frequent physical fighting ( 66 ), excessive television/video game/internet use ( 67 , 68 ), insufficient sleep ( 69 ), and even soft drink consumption ( 70 ). With so many variables being associated with suicidality in youth—especially given the very large national sample allowing the identification of statistically significant findings with small effect sizes—it is not particularly surprising that concussion was also associated in the present study, in univariate analyses, and in prior studies using the 2013 ( 45 ) and 2017 YRBS ( 41 – 43 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Concussions and Suicidality in High School Students in the United States

Iverson

Karr

2022

Front. Neurol.

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ImportancePrior research has shown a statistically significant association between sustaining a concussion and suicidality in adolescents, but this prior research controlled for relatively few variables predictive of suicidality.ObjectiveTo examine whether sustaining a concussion remained a significant predictor of suicidality after controlling for relevant covariates (e.g., sexual abuse/assault, bullying, substance use, depression), hypothesizing that the relationship between concussion and suicidality would become non-significant after controlling for these variables.DesignThis study involved secondary data analysis of the 2019 Youth Risk Behavior Surveillance (YRBS) System, a national cross-sectional study of adolescents. Analyses were stratified by gender.SettingA national sampling of U.S. high school students.ParticipantsEleven thousand two hundred sixty-two students in the YRBS database, including 5,483 boys and 5,779 girls.Exposure(s)Participants included in the analyses reported whether, in the last year, they experienced a concussion and/or suicidality.Main Outcomes and MeasuresThe main outcome was suicidality (i.e., ideation, planning, attempt), which was predicted by concussion in an unadjusted analysis and by concussion along with other risk factors in a multivariable analysis.ResultsThe final sample included 11,262 participants with available data on concussion and suicidality in the last year (14–18 years-old; 51.3% girls; 49.0% White). Per unadjusted odds ratios with 95% confidence intervals, there was a relationship between concussion and suicidal ideation [girls: OR = 1.46 (1.24, 1.73); boys: OR = 1.69 (1.41, 2.03)], planning (girls: OR = 1.39 [1.16, 1.66]; boys: OR = 1.76 [1.44, 2.14]), and attempt [girls: OR = 1.70 (1.32, 2.19); boys: OR = 3.13, (2.37, 4.15)]. These relationships became mostly non-significant after controlling for relevant risk factors for suicidality. The adjusted odds ratios showed no relationship between concussion and suicidal ideation [girls: OR = 1.11 (0.86, 1.44); boys: OR = 1.24 (0.92, 1.69)] or planning (girls: OR = 1.07 [0.82, 1.40]; boys: OR = 1.12 [0.82, 1.55]); but a significant relationship with suicide attempts in boys [OR = 1.98 (1.28, 3.04)], but not girls [OR = 1.05 (0.74, 1.49)].Conclusions and RelevanceThere was an association between concussion and suicidality in U.S. high school students; however, after controlling for other variables (e.g., depression, sexual abuse/assault, illicit drug use), there was no association between concussion and suicidality aside from a significant relationship between concussion and attempts in boys.

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“…Thirdly, this study focused mainly on the impacts of parenting styles on adolescents’ depressive symptoms and suicidal ideation. However, according to ecological systems theory [ 89 , 90 ], adolescents’ depressive symptoms and suicidal ideation may act as risk factors to induce parents’ harsh parenting and aggravate the effects of harsh parenting, causing a vicious circle and exacerbating adolescents’ mental health problems [ 1 ]. Therefore, future studies are encouraged to explore the potential interaction process relationships between harsh parenting and adolescent mental health problems.…”

Section: Discussionmentioning

confidence: 99%

The Role of Mindfulness in Mitigating the Detrimental Effects of Harsh Parenting among Chinese Adolescents: Testing a Moderated Mediation Model in a Three-Wave Study

Sun

Guo

Spruyt

et al. 2022

IJERPH

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Based on the conservation of resources theory, this study aimed to investigate the mediating role of depressive symptoms and the moderating role of mindfulness in the association between harsh parenting and adolescent suicidal ideation in the Chinese cultural context. Using a three-wave (i.e., three months apart) data collection among 371 Chinese adolescents, this study found that depressive symptoms mediated the relationship between harsh parenting and adolescent suicidal ideation. Moreover, adolescent mindfulness mitigated the effects of harsh parenting on suicidal ideation, as well as the indirect effect of harsh parenting on suicidal ideation via depressive symptoms. The theoretical and practical implications are discussed.

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Social‐ecological theory, substance misuse, adverse childhood experiences, and adolescent suicidal ideation: Applications for community–academic partnerships

Cited by 20 publications

References 46 publications

Dissecting early life stress-induced adolescent depression through epigenomic approach

Dissecting early life stress-induced adolescent depression through epigenomic approach

Association Between Concussions and Suicidality in High School Students in the United States

The Role of Mindfulness in Mitigating the Detrimental Effects of Harsh Parenting among Chinese Adolescents: Testing a Moderated Mediation Model in a Three-Wave Study

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