Social Exclusion Leads to Divergent Changes of Oxytocin Levels in Borderline Patients and Healthy Subjects

Jobst, Andrea; Albert, A.; Bauriedl-Schmidt, Christine; Mauer, Maria Christine; Renneberg, Babette; Buchheim, Anna; Sabaß, L.; Falkai, Peter; Zill, Peter; Padberg, Frank

doi:10.1159/000358526

Cited by 47 publications

(34 citation statements)

References 10 publications

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“…After playing a virtual ball‐tossing game that mimicked social exclusion, patients with BPD responded with more prolonged negative emotions and a reduction in serum OT level. Moreover, the speed of return to baseline correlated negatively with childhood trauma severity (Jobst et al ., ).…”

Section: Oxytocin System In Bpdmentioning

confidence: 97%

On the role of oxytocin in borderline personality disorder

Brüne

2015

British J Clinic Psychol

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The study of oxytocin can contribute to the understanding of the neurobiology of borderline personality disorder. Oxytocin is critically involved in attachment security, and methylation of the oxytocin receptor may play a role in the epigenetic modulation of early adversity. The intranasal application of oxytocin may be a useful therapeutic adjunct to psychotherapy. Insecure attachment and childhood adversity may produce differential neurobiological effects on the oxytocinergic system in borderline personality disorder. There is insufficient knowledge of how oxytocin interacts with vasopressin, testosterone, dopamine, and serotonin, which are also important key players in the experience of social reward and stress responsivity. It is unclear whether or not oxytocin could be beneficial in preventing the intergenerational (non-genetic) transmission of borderline personality traits.

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Section: Oxytocin System In Bpdmentioning

confidence: 97%

On the role of oxytocin in borderline personality disorder

Brüne

2015

British J Clinic Psychol

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“…These findings are consistent with an association between lower OT levels in women reporting childhood abuse (Heim et al , ), a condition often found in patients with BPD. When experimentally exposed to social stress in a virtual ball‐tossing game imitating social exclusion, patients with BPD responded with more prolonged negative emotions and a decrease in serum OT level, whereby the speed of return to baseline OT correlated negatively with childhood trauma severity (Jobst et al , ).…”

Section: Nonverbal Synchronymentioning

confidence: 99%

Exploring nonverbal synchrony in borderline personality disorder: A double‐blind placebo‐controlled study using oxytocin

Ramseyer

Ebert

Roser

et al. 2019

British J Clinic Psychol

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Objectives. Interpersonal dysfunction is a central feature of borderline personality disorder (BPD), and the neuropeptide oxytocin (OT) has been shown to impact patients' behaviour in numerous ways. Nonverbal signals such as the coordination of body movement (nonverbal synchrony) are associated with the success of interpersonal exchanges and could thus be influenced by features of BPD and by the administration of OT.Design. We explored the effect of intranasal OT (inOT) on nonverbal synchrony in sixteen patients with BPD and fifteen healthy controls (CTL) randomly assigned to two double-blind clinical interviews under inOT and placebo (PL).Methods. Nonverbal synchrony was assessed by automated video-analyses of subject's and interviewer's body movement. Lagged cross-correlations were used to objectively quantify coordination in dyads.Results. Synchrony was higher than pseudosynchrony (= synchrony expected by chance), and there was a differential effect of inOT between groups: While healthy controls displayed increased synchrony under inOT, patients with BPD showed low levels of synchrony under inOT. Additionally, patient's synchrony was negatively associated with self-reported childhood trauma.

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“…During the last decades, however, research has focused on the role of OT in social cognition and behavior in both nonhuman animals and humans, including patients with BPD (reviewed in Brüne, ). OT in BPD exerts differential effects on fear, affiliation, and trust, as well as rejection sensitivity, whereby fear reduction is not paralleled by an increase in trust and prosocial behavior (Bartz et al., ; Brüne, Kolb, Ebert, Roser, & Edel, ; Ebert et al., ; Jobst et al., ). In addition, peripheral OT seems to be either generally lower in BPD patients than in controls (Bertsch, Schmidinger, Neumann, & Herpertz, ), or at least in a subgroup with unresolved attachment representations (Jobst et al., ).…”

Section: Introductionmentioning

confidence: 99%

Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder

Ebert

Edel²,

Gilbert

et al. 2017

Depress Anxiety

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Background/Objective: The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of compassion and recalled parental behavior during childhood.Methods: Fifty-seven BPD patients and 43 healthy controls participated in the study. OT plasma levels were analyzed by radioimmunoassay. Subjects additionally completed questionnaires focusing on fears of compassion (FOC) and recalled upbringing ("Questionnaire of Recalled Parental Rearing Behavior/Fragebogen zum erinnerten elterlichen Erziehungsverhalten," FEE).Results: BPD patients had significantly lower OT plasma levels than healthy controls and differed significantly on all FOC and FEE scales; BPD patients had higher FOC scores (indicating more aversion of being compassionate to themselves and others and receiving compassion from others).They also differed in recalled parenting. In the BPD group, scores of the FOC scale "fear of compassion from others" were significantly negatively correlated with OT levels. Moreover, recalled "emotional warmth" of their parents during childhood was positively correlated with OT plasma levels of BPD subjects. No such correlations were found in the control group. Conclusion:Our results corroborate findings from previous studies reporting lower OT levels in patients with BPD. Moreover, peripheral OT seems to be linked with the tolerance of compassionate feelings and early experiences with caregivers. This is consistent with other findings that OT is an important mediator of the experience of emotional warmth from others.

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Social Exclusion Leads to Divergent Changes of Oxytocin Levels in Borderline Patients and Healthy Subjects

Cited by 47 publications

References 10 publications

On the role of oxytocin in borderline personality disorder

On the role of oxytocin in borderline personality disorder

Exploring nonverbal synchrony in borderline personality disorder: A double‐blind placebo‐controlled study using oxytocin

Endogenous oxytocin is associated with the experience of compassion and recalled upbringing in Borderline Personality Disorder

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