Social influences and cardiovascular risk factors as determinants of plasma fibrinogen concentration in a general population sample of middle aged men.

Rosengren, Annika; Wilhelmsen, Lars; Welin, Lennart; Tsipogianni, A; Teger‐Nilsson, Ann‐Catrine; Wedel, Hans

doi:10.1136/bmj.300.6725.634

Cited by 139 publications

(69 citation statements)

References 25 publications

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“…Of these four variables, two are significant in the multivariate analysis. In the Gothenburg 1933 study, 19 a negative association between activity score and fibrinogen level was found. This activity score is comparable with our loneliness variable.…”

Section: Discussionmentioning

confidence: 99%

“…No such association was found in the Whitehall Study 15 ; however, that study population was very small (7V=74). In the Gothenburg 1933 Study, 19 a very significant negative association between physical activity and fibrinogen was found. This association became insignificant in the multivariate analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Apparently, the relation between cohabitation and fibrinogen has only been examined in the Gothenburg 1933 study, in which Rosengren et al 19 found a negative association between fibrinogen level and the number of people in the household for nonsmokers. It should be noted that this is consistent with the finding in a number of studies, which shows that lack of a social network or support is a risk factor for cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…The authors of this study concluded that fibrinogen was a possible link in the causal chain connecting low social class with increased risk of cardiovascular disease. Also, Meade et al 16 - 17 and Rosengren et al 19 found a negative correlation between social class and fibrinogen level.…”

Section: M0ller and Kristensen Fibrinogen And Chd Riskmentioning

confidence: 99%

“…148 - 19 All studies except one 9 found a strong positive association between smoking and fibrinogen level, and several 1 -41719 - 20 concluded that fibrinogen level probably explained a considerable part of the causal association between smoking and cardiovascular disease.…”

Section: M0ller and Kristensen Fibrinogen And Chd Riskmentioning

confidence: 99%

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Plasma fibrinogen and ischemic heart disease risk factors.

Møller

Kristensen

1991

Arterioscler Thromb

122

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The association between risk factors for ischemic heart disease and plasma fibrinogen level was analyzed in a cross-sectional population study. All 51-year-old men living in a certain area within the county of Copenhagen were invited; 439 of 542 (81%) participated in the study. Data were collected via questionnaire and at health examinations. The following independent variables were analyzed: social variables, which included social class, marital status, and job strain; psychological and psychosomatic variables, which included abdominal pain, personal and economic problems, self-assessed state of health, and degree of loneliness; behavioral variables, which included smoking, drug consumption, physical activity, use of sugar, and alcohol consumption; and physiological variables, which included high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, physical fitness, fasting glucose level, waist-to-hip ratio, and systolic blood pressure. In the multivariate analyses, the following variables showed an independent positive association with plasma fibrinogen level: one social variable (low social class); two psychological variables (abdominal pain index and personal/ economic problems); two behavioral variables (smoking and physical inactivity during leisure time); and three physiological variables (low HDL cholesterol, low physical fitness, and high LDL cholesterol). The strongest independent associations with plasma fibrinogen level were found for smoking, social class, LDL cholesterol, and HDL cholesterol. These analyses suggest that smoking is a major risk factor for an elevated plasma fibrinogen level, but that other factors such as social class, cholesterol level, physical inactivity/physical fitness, and psychological problems also influence plasma fibrinogen level. Study,7 in which a cohort of 297 men from one general practice was followed for an average of 7.3 years.All four studies showed a clear association between fibrinogen level and the incidence of ischemic heart disease in the follow-up period. In the Goth-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%