Social instability in female rodents as a model of stress related disorders: A systematic review

Goñi‐Balentziaga, Olatz; Pérez-Tejada, Joana; Renteria-Dominguez, Aitor; Lebeña, Andrea; Labaka, Ainitze

doi:10.1016/j.physbeh.2018.09.001

Cited by 23 publications

(12 citation statements)

References 78 publications

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“…However, while women are more vulnerable to psychosocial stress and are more prompt to develop depressive-like behaviours (Kessler 2003; Albert 2015; Kuehner 2017), a serious dearth in female-based animal models of depression persists (Beery and Zucker 2011). This caveat has been explored in some studies to develop a relevant social depression model for females: interestingly, chronic social instability in females can elicit depressive-like symptoms in rats (Haller et al 1999; Herzog et al 2009; Goñi-Balentziaga et al 2018) and mice (Tamashiro et al 2005; Saavedra-Rodríguez and Feig 2013; Goñi-Balentziaga et al 2018). This paradigm consists of several weeks of social instability such as an alternation of isolation/crowding phases lasting from 1 to 48 h depending on protocols.…”

Section: Behavioural Endpoints and Animal Models Of Mddmentioning

confidence: 99%

“…This paradigm consists of several weeks of social instability such as an alternation of isolation/crowding phases lasting from 1 to 48 h depending on protocols. Such procedures can lead to a decrease in appetite, changes in the circadian cycle, an elevation of adrenal and corticosterone levels and a decrease of sucrose preference which reflects anhedonia (Herzog et al 2009; Goñi-Balentziaga et al 2018). Additionally, this paradigm has also been tested on male rats, inducing an alteration of hippocampal neurogenesis and deficits in spatial learning (McCormick et al 2012).…”

Section: Behavioural Endpoints and Animal Models Of Mddmentioning

confidence: 99%

“…Moreover, a recent study showed that chronic instability during adolescence can induce anxiety-like behaviours in male rats. Nevertheless, chronic social instability shows some contradictory results among studies, probably due to discrepancies between protocols: future research should be careful to design reproducible protocols that can be compared between studies (for review see Goñi-Balentziaga et al 2018).…”

Section: Behavioural Endpoints and Animal Models Of Mddmentioning

confidence: 99%

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Animal models of major depression: drawbacks and challenges

2019

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Major depression is a leading contributor to the global burden of disease. This situation is mainly related to the chronicity and/or recurrence of the disorder, and to poor response to antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating the environment to which rodents are exposed (during the developmental period or adulthood) or biological underpinnings (i.e. gene deletion or overexpression of candidate genes, targeted lesions of brain areas, optogenetic control of specific neuronal populations, etc.). These manipulations can alter specific behavioural and biological outcomes that can be related to different symptomatic and pathophysiological dimensions of major depression. However, animal models of major depression display substantial shortcomings that contribute to the lack of innovative pharmacological approaches in recent decades and which hamper our capabilities to investigate treatment-resistant depression. Here, we discuss the validity of these models, review putative models of treatment-resistant depression, major depression subtypes and recurrent depression. Furthermore, we identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical approaches to depression.

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Section: Behavioural Endpoints and Animal Models Of Mddmentioning

confidence: 99%

Section: Behavioural Endpoints and Animal Models Of Mddmentioning

confidence: 99%

Section: Behavioural Endpoints and Animal Models Of Mddmentioning

confidence: 99%

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Animal models of major depression: drawbacks and challenges

2019

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“…Induce both anxiety-and depression-like behaviors in OF, EPM, sucrose preference and social interaction tests [126][127][128][129].…”

Section: Social Instability Stress (Sis)mentioning

confidence: 99%

“…In addition, this model is pertinent mainly to male mice and to specific strains. As social defeat stress is not well adaptable to female rodents because they are less aggressive, the social instability stress (SIS) model was introduced for female animals [127].…”

Section: Chronic Social Defeat Stressmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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Ginsenoside Rh2 administration produces crucial antidepressant‐like effects in a CUMS‐induced mice model of depression

Shi

Liu

et al. 2022

Brain and Behavior

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Introduction The most striking feature of depression is sadness and a loss of interest in activities, which represents a major cause of disability globally. Therefore, it is necessary to identify novel antidepressants for clinical practice. Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides that can be extracted from Panax ginseng and has been demonstrated to improve both memory and learning. The purpose of this study was to provide broad insight into the mechanisms underlying depression and gain greater insights into antidepressant therapy. Methods In this study, we first established an effective and feasible depression animal model of chronic unpredictable mild stress (CUMS) and behavioral testing was evaluated by the forced swim test (FST), the tail suspension test (TST) and the sucrose preference test. Following pretreatment with Rh2 (10 and 20 mg/kg), the immobility time of mice was reduced without affecting locomotor activity in both the FST and TST. Western blotting and immunofluorescence were used to investigate the activation of the hippocampal BDNF signaling pathway and hippocampal neurogenesis. Results Different concentrations of Rh2 significantly reduced depressive‐like symptoms in CUMS‐induced mice and downregulated the effects of the BDNF signaling cascade and neurogenesis in the hippocampus. Furthermore, the administration of K252a completely prevented the antidepressant‐like activity of Rh2 in mice. Conclusion The results indicated that Rh2 possesses the antidepression action via the positive regulation of the BDNF‐TrkB pathway.

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Social instability in female rodents as a model of stress related disorders: A systematic review

Cited by 23 publications

References 78 publications

Animal models of major depression: drawbacks and challenges

Animal models of major depression: drawbacks and challenges

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Ginsenoside Rh2 administration produces crucial antidepressant‐like effects in a CUMS‐induced mice model of depression

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