Social isolation: Effects on pain threshold and stress-induced analgesia

Puglisi‐Allegra, Stefano; Oliverio, Alberto

doi:10.1016/0091-3057(83)90344-1

Cited by 76 publications

(36 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fear and anxiety responses are organized at different levels in a putative rostro-caudal hierarchical circuitry for defense reactions (McNaughton & Corr, 2004); therefore, we predict that direct exposure to threatening stimuli should induce high levels of fear and arousal and inhibit pain, whereas exposure to diffuse or potentially threatening stimuli (e.g., novelty) induce a state of anxiety and enhance pain (Rhudy & Meagher, 2000). Aside from anxiety and fear, stressful stimuli that do not produce fear but induce neuroendocrine responses (e.g., restraint stress, social isolation, and forced swimming) can induce analgesia (Bodnar, Glusman, Brutus, Spiaggia, & Kelly, 1979;Bodnar, Kelly, Spiaggia, Ehrenberg, & Glusman, 1978;Bodnar, Merrigan, & Sperber, 1983;Costa, Smeraldi, Tassorelli, Greco, & Nappi, 2005;Puglisi-Allegra & Oliverio, 1983), an effect that is mediated by hypothalamicpituitary-adrenal axis hormones (Butler & Finn, 2009).…”

Section: Introductionmentioning

confidence: 99%

Modulation of nociceptive-like behavior in zebrafish (Danio rerio) by environmental stressors.

Maximino

2011

Psychology & Neuroscience

View full text Add to dashboard Cite

Zebrafish have been demonstrated to react consistently to noxious chemical stimuli and present reliable phenotypes of stress, fear, and anxiety. In this article, we describe the modulation of nociceptive-like responses of zebrafish to fear-, stress-, and anxiety-eliciting situations. Animals were exposed to an alarm substance, confinement stress, or a novel environment before being injected with 1% acetic acid in the tail. The alarm substance and confinement stress reduced the display of erratic movements and tail-beating behavior elicited by acetic acid. The novelty of the environment, in contrast, increased the frequency of tail-beating behavior. The results suggest that descending modulatory control of nociception exists in zebrafish, with apparent fear-and stress-induced analgesia and anxiety-induced hyperalgesia.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulation of nociceptive-like behavior in zebrafish (Danio rerio) by environmental stressors.

Maximino

2011

Psychology & Neuroscience

View full text Add to dashboard Cite

show abstract

“…Effects of isolation rearing on cognition in rats Early observations of behaviour in rats reared in isolation led to the portrayal of the "isolation syndrome" (Hatch et al, 1965;Sahakian et al, 1977). Rats reared in isolation from weaning until adulthood show several behavioural changes, consistently including increased locomotor activity, anxiogenesis, (Puglisi-Allegra and Oliverio, 1983), enhanced sensitivity to psychoactive drugs such as amphetamine and cocaine (Jones et al, 1990;Smith et al, 1997) and sensorimotor gating deficits as measured by reduced pre-pulse inhibition (PPI) of a startle response (Geyer et al, 1993;Cilia et al, 2001;. However, relatively few reports have investigated the effect of isolation rearing in cognition (Schrijver and Wurbel, 2001;Dalley et al, 2002;Weiss et al, 2004, Li et al, 2007.…”

Section: Introductionmentioning

confidence: 99%

Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats

et al. 2008

View full text Add to dashboard Cite

Rationale: It has been suggested that the isolation rearing paradigm models certain aspects of schizophrenia symptomology. Objective: This study aimed to investigate whether isolation rearing impairs rats' performance in two models of cognition: the novel object recognition and attentional set-shifting tasks, tests of episodic memory and executive function respectively. Methods: Two cohorts of female Hooded-Lister rats were used in these experiments. Animals were housed in social isolation or in groups of five from weaning, post-natal day 28. The first cohort was tested in the novel object recognition test with inter-trial intervals (ITI) of 1 min up to 6 hours. The second cohort was trained and tested in the attentional set-shifting task. Results: In the novel object recognition test isolates were only able to discriminate between the novel and familiar objects up to 1 hour ITI, whereas socially reared animals remembered the familiar object up to a 4 hour ITI. In the attentional set shifting task isolates were significantly and selectively impaired in the EDS phase of the task (p<0.01). Conclusions: Rats reared in isolation demonstrate impaired episodic memory in the novel object recognition task and reduced ability to shift attention between stimulus dimensions in the attentional set-shifting task. Since schizophrenic patients show similar deficits in performance in these cognitive domains these data further support isolation rearing as a putative preclinical model of the cognitive deficits associated with schizophrenia.

show abstract

“…For example, housing isolation and crowding can both affect animal welfare (e.g., ref. 37), and directly affect pain sensitivity [38][39][40][41][42][43] , and the effects of cage density might be sex-specific 44 . Housing enrichment using physical objects has been shown to ameliorate pain [45][46][47] .…”

Section: Jeffrey S Mogilmentioning

confidence: 99%

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Mogil

2017

Lab Anim

View full text Add to dashboard Cite

Social isolation: Effects on pain threshold and stress-induced analgesia

Cited by 76 publications

References 12 publications

Modulation of nociceptive-like behavior in zebrafish (Danio rerio) by environmental stressors.

Modulation of nociceptive-like behavior in zebrafish (Danio rerio) by environmental stressors.

Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Contact Info

Product

Resources

About