Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice

Park, Gaeun; Ryu, Changhyeon; Kim, Soobin; Jeong, Se Jin; Koo, Ja Wook; Lee, Yong-Seok; Kim, Sang Jeong

doi:10.1016/j.celrep.2021.109104

Cited by 62 publications

(51 citation statements)

References 66 publications

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“…In the rhinencephalon and telencephalon, Acb-projecting neurons mainly originate from the anterior olfactory nucleus, Cl, IL, BMA, and VS in tree shrews, which is in agreement with previous results in mice (Li et al, 2018;Ma et al, 2020). According to previous findings, the IL-Acb pathway plays a critical role in cocaine seeking, ethanol-induced behavior, decision-making modality, and social recognition (Sweis et al, 2018;Bechard et al, 2021;Ferreira et al, 2021;Park et al, 2021). In addition, previous findings highlight a role for the VS-Acb pathway in cocaine seeking, schizophrenia, and stress susceptibility (McGlinchey et al, 2016;Lee et al, 2019;Saoud et al, 2020).…”

Section: Brain-wide Afferent Projections To the Accumbens Nucleussupporting

confidence: 92%

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

Shu

et al. 2021

Front. Neuroanat.

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Day-active tree shrews have a well-developed internal capsule (ic) that clearly separates the caudate nucleus (Cd) and putamen (Pu). The striatum consists of the Cd, ic, Pu, and accumbens nucleus (Acb). Here, we characterized the cytoarchitecture of the striatum and the whole-brain inputs to the Cd, Pu, and Acb in tree shrews by using immunohistochemistry and the retrograde tracer Fluoro-Gold (FG). Our data show the distribution patterns of parvalbumin (PV), nitric oxide synthase (NOS), calretinin (CR), and tyrosine hydroxylase (TH) immunoreactivity in the striatum of tree shrews, which were different from those observed in rats. The Cd and Pu mainly received inputs from the thalamus, motor cortex, somatosensory cortex, subthalamic nucleus, substantia nigra, and other cortical and subcortical regions, whereas the Acb primarily received inputs from the anterior olfactory nucleus, claustrum, infralimbic cortex, thalamus, raphe nucleus, parabrachial nucleus, ventral tegmental area, and so on. The Cd, Pu, and Acb received inputs from different neuronal populations in the ipsilateral (60, 67, and 63 brain regions, respectively) and contralateral (23, 20, and 36 brain regions, respectively) brain hemispheres. Overall, we demonstrate that there are species differences between tree shrews and rats in the density of PV, NOS, CR, and TH immunoreactivity in the striatum. Additionally, we mapped for the first time the distribution of whole-brain input neurons projecting to the striatum of tree shrews with FG injected into the Cd, Pu, and Acb. The similarities and differences in their brain-wide input patterns may provide new insights into the diverse functions of the striatal subregions.

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Section: Brain-wide Afferent Projections To the Accumbens Nucleussupporting

confidence: 92%

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

Shu

et al. 2021

Front. Neuroanat.

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“…Interestingly, the social recognition memory deficit induced by the social isolation of the adult mice can be recovered by group housing for more than a few weeks ( Park et al, 2021 ). However, the post-weaned juvenile mice that were singly housed for eight weeks still suffered social recognition memory deficits after they were group-housed for four weeks for re-socialization ( Park et al, 2021 ). When group-housed mice encountered the familiar conspecifics, neurons in the infralimbic area of the prefrontal cortex (IL) projecting to the NAc shell showed activation.…”

Section: The Effect Of Social Isolation On Social Recognition Memorymentioning

confidence: 99%

Regulation of Social Recognition Memory in the Hippocampal Circuits

Wang

Zhan

2022

Front. Neural Circuits

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Social recognition memory reflects the ability of the social animals to recognize and remember familiar individuals of the same species. The unique ability for mammals to recognize conspecifics is essential and beneficial when animals conduct daily social activities. This brief review summarizes a brain network underlying social recognition memory and explores the possible relationships between social isolation and social recognition memory. Finally, we introduce some possible related molecular mechanisms underlying social recognition memory. These findings help us explore potential targeting brain areas or circuits of social communication disorder.

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“…Social play behavior has a crucial role in the normal development of cognitive and social interactions in young animals, which has been demonstrated after social isolation [ 128 , 129 ]. Moreover, early social dysfunction is observed in ASD and ADHD.…”

Section: Neuropsychiatric Conditions: Ot and Avp Rolementioning

confidence: 99%

Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

Cid-Jofré

Moreno

Reyes‐Parada

et al. 2021

IJMS

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Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders.

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Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice

Cited by 62 publications

References 66 publications

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

Regulation of Social Recognition Memory in the Hippocampal Circuits

Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

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