Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test

Wongwitdecha, Noppamars; Marsden, C.A.

doi:10.1016/0166-4328(96)00181-7

Cited by 192 publications

(104 citation statements)

References 32 publications

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“…Previous studies have shown that gamma-aminobutyric acid A (GABA A ) receptor agonists, 5-HT 1A receptor agonists, and mGlu 2/3 receptor agonists attenuate isolation-rearinginduced aggressive behaviors and/or anxiety-like behaviors (Ago et al, 2012;Da Silva et al, 1996;Maisonnette et al, 1993;Sakaue et al, 2001;Sánchez et al, 1993;Wongwitdecha and Marsden, 1996). Thus, we next examined the effects of the GABA A receptor agonist diazepam, the 5-HT 1A receptor agonist osemozotan, and the mGlu 2/3 receptor agonist LY379268 on encounter-induced behavioral changes in male isolation-reared mice ( Figure 5).…”

Section: Effects Of Diazepam Osemozotan and Ly379268 On Encounter-imentioning

confidence: 99%

“…Diazepam is a potent anxiolytic (do-Rego et al, 2006) and attenuates aggressive behavior (Sakaue et al, 2001;Wongwitdecha and Marsden, 1996) and anxiety-like behavior in the elevated plus-maze (Da Silva et al, 1996) in isolation-reared rodents. Osemozotan and mGlu 2/3 receptor agonists also inhibit aggressive behavior and anxiety-like behavior in the elevated plus-maze, and they reverse the deficits of prepulse Figure 8 Effects of diazepam and osemozotan (a), and LY379268 (b) on encounter-induced increases in extracellular 5-HT levels in the nucleus accumbens shell of male isolation-reared mice.…”

Section: Effect Of Encounter Stimulation In Isolated Mice Y Ago Et Almentioning

confidence: 99%

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Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice

Ago

Araki

Tanaka

et al. 2013

Neuropsychopharmacol

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Isolation-reared male rodents show abnormal behaviors such as hyperlocomotion, aggressive behaviors, deficits of prepulse inhibition, and depression-and anxiety-like behaviors, but the neurochemical mechanism for the effects of psychological stress in these animals is not fully understood. This study examined the effects of social interactions between isolation-reared mice and intruder mice on brain monoaminergic systems. A cage was divided into two compartments by a mesh partition to prevent direct physical interactions. The 20-min encounter with an intruder elicited a restless and hyperexcitable state (hyperactivity) in male, but not in female, isolationreared mice, whereas encounters with a sleeping intruder or a novel object did not. Although the encounter did not affect prefrontal neuronal-activity-marker c-Fos expression, dopamine (DA) levels, or serotonin (5-HT) levels in male group-reared mice or female isolation-reared mice, it increased prefrontal c-Fos expression, DA levels, and 5-HT levels in male isolation-reared mice. Furthermore, encounter-induced increases in c-Fos expression in the dorsal raphe nucleus and ventral tegmental area, but not in the nucleus accumbens shell, were much greater in isolation-reared than group-reared male mice. A 5-HT 1A receptor agonist, a metabotropic glutamate 2/3 receptor agonist, and a gamma-aminobutyric acid A receptor agonist attenuated isolation-induced aggressive behaviors and encounter-induced hyperactivity, c-Fos expression in the prefrontal cortex and dorsal raphe nucleus, and increases in prefrontal 5-HT levels. These findings suggest that the prefrontal DA and 5-HT systems are activated by encounter stimulation in male isolationreared mice, and the encounter-induced activation of 5-HT system triggers the induction of some abnormal behaviors in male isolation-reared mice. Furthermore, this study implies that the encounter stimulation-induced signal has a pharmacological significance.

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Section: Effects Of Diazepam Osemozotan and Ly379268 On Encounter-imentioning

confidence: 99%

Section: Effect Of Encounter Stimulation In Isolated Mice Y Ago Et Almentioning

confidence: 99%

Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice

Ago

Araki

Tanaka

et al. 2013

Neuropsychopharmacol

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“…Anxiety-like behavior of isolation-reared rats was reported in the open-field (9), elevated plus-maze (10 -14), and Vogel conflict (11) tests. In contrast, anxiety-like behavior was not observed in the social interaction test (4,15). Conversely, an anxiolytic-like effect was shown in the elevated plus-maze test using rats (16) and mice (17 -19).…”

Section: Introductionmentioning

confidence: 86%

“…Long-term social isolation induces hyperactivity (1,2), less habituation in a novel environment (3), aggressive behavior (4,5), and deficits in prepulse inhibition of acoustic startle (6 -8) in rodents. Less habituation to a novel environment and aggressive behavior may be related to an anxiety-like state, but there are discrepant reports on anxiety-related behavior in isolation-reared animals.…”

Section: Introductionmentioning

confidence: 99%

Anxiety-Like and Exploratory Behaviors of Isolation-Reared Mice in the Staircase Test

et al. 2007

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Abstract. The behavior of isolation-reared mice has not yet been studied in the staircase test. The present study examined the effects of anxiolytic or anxiogenic agents and isolation rearing on the behavior of ddY (outbred) strain mice in the staircase test. Diazepam and phenobarbital increased the number of steps climbed, but did not affect rearing behavior in group-reared mice. FG-7142, a benzodiazepine inverse agonist, significantly increased the number of rearing with no changes in the number of steps climbed in group-reared mice. Methamphetamine increased the number of steps climbed and decreased the number of rearing in group-reared mice. Although isolation-reared mice showed hyperactivity, there was no difference in locomotor activity for the test period of 3 min between isolation-and group-reared mice. Under these conditions, isolation rearing increased the numbers of steps climbed and rearing compared to group-reared controls. Microanalysis of locomotor patterns of group-reared mice in the staircase test showed that anxiolytic drugs increased the number of climbing to the top step of the staircase and methamphetamine increased the number of climbing to the first to third step. These results suggest that isolation rearing causes an anxiety-like state with increased exploratory behavior in mice.

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“…However, the effects of SI were found not to depend on strain and were more pronounced on locomotion (central and peripheral were decreased) than in anxiety-behaviors. SI may increase locomotor activity in a new environment (Hall et al, 1998;Thorsell et al, 2006;Ago et al, 2007), trigger aggressive behaviors (Wongwitdecha et al, 1996), induce deficits in prepulse inhibition (Weiss et al, 1999), and cause changes in endocrine parameters (Pohorecky et al, 2008). SI is also capable of inducing morphological changes in length and dendritic density of neurons localized in the prefrontal cortex and nucleus accumbens, which are associated with increased locomotor activity in a novel and stressful environment (Alquicer et al, 2004;.…”

Section: 3 Statistical Analysismentioning

confidence: 99%

Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains

Mazur

Oliveira

Cunha

et al. 2017

Behavioural Processes

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Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test

Cited by 192 publications

References 32 publications

Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice

Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice

Anxiety-Like and Exploratory Behaviors of Isolation-Reared Mice in the Staircase Test

Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains

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