Social isolation, inflammation, and cancer mortality from the National Health and Nutrition Examination Survey - a study of 3,360 women

Koh-Bell, Alexander; Chan, J.K.; Mann, Amandeep; Kapp, Daniel S.

doi:10.1186/s12889-021-11352-0

Cited by 5 publications

(5 citation statements)

References 39 publications

(52 reference statements)

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“…Secondly, having more family obligations and social activities can help improve mobility and motor function [11]. Thirdly, elevated psychological stress in socially isolated individuals alters the neuroendocrine system [12]. Social isolation may contribute to muscle loss by inducing chronic low-grade inflammation [6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Social Isolation on Sarcopenia: A Longitudinal Study among the Middle-Aged and Older Population in China

Zhang

Wong

et al. 2023

Gerontology

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Introduction: Although social isolation is associated with premature death and somatic and mental diseases, evidence of its long-term effect on sarcopenia is scarce. This study aimed to examine the longitudinal association between social isolation and possible sarcopenia. Methods: We extracted baseline and four-year follow-up data from the China Health and Retirement Longitudinal Study and included participants aged 45 years or above. Social isolation was measured by factors including living alone, marital status, frequency of contact with adult children and friends, and participation in social activity. The change in social isolation from baseline to follow-up was classified into stable, progressive, and regressive groups. Possible sarcopenia was detected using the handgrip strength and five-time chair stand test. Using mixed effects logistic regression, we studied the effect of baseline isolation and the change in isolation status on possible sarcopenia at a four-year follow-up. Results: A total of 5289 participants aged 45 to 90 years and without possible sarcopenia at baseline were included. After four years, possible sarcopenia was detected in 21.7% (1146/5289) of the participants. Compared with the low social isolation group, the middle (OR=1.53, 95% confidence interval [CI]=1.16~2.04, p=0.003) and high social isolation groups (OR=1.65, 95% CI=1.26~2.18, p<0.001) were associated with a higher risk of possible sarcopenia. Being not married/cohabiting (OR=1.58, 95% CI=1.19~2.10, p=0.002), lack of contact with children (OR=1.86, 95% CI=1.21~2.85, p=0.004), and lack of social activities (OR=1.26, 95% CI=1.04~1.53, p=0.019) were associated with an increased risk of possible sarcopenia. Compared with the stable social isolation group, the progressive group was associated with a greater risk of possible sarcopenia (OR=1.51, 95% CI=1.17~1.95, p=0.001). Conclusions: Social isolation is associated with an increased risk of possible sarcopenia. Progressive social isolation further elevates the risk. The most vulnerable groups are middle-aged and older people who live alone, are not socially active, and lack contact with their children.

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Section: Introductionmentioning

confidence: 99%

The Effect of Social Isolation on Sarcopenia: A Longitudinal Study among the Middle-Aged and Older Population in China

Zhang

Wong

et al. 2023

Gerontology

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“…This can be explained as follows. First, compared to those with limited social participation, engaging in active social participation is associated with lower levels of inflammation [ 41 , 42 ]. Second, social participation motivates healthy lifestyles through good social relationships [ 42 , 43 ]).…”

Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences, sarcopenia, and social participation in older adults: a cohort study

Huang,

Li,

et al. 2024

BMC Public Health

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Objectives To examine the relationships between adverse childhood experiences (ACEs) and developing sarcopenia in older adults and the modifying effects of active social participation. Methods This prospective cohort study used survey data from the China Health and Retirement Longitudinal Study, including baseline surveys from 2011, follow-up data from 2013, follow-up data from 2015, and information on ACEs from the 2014 Life History Survey. Information concerning 10 ACEs, including five threat-related ACEs and five deprivation-related ACEs before 17 years of age was obtained by questionnaires through face-to-face interviews. Sarcopenia status was assessed according to the Asian Working Group for Sarcopenia 2019 algorithm, consisted of low muscle mass, and low muscle strength, or poor physical performance. The relationship between ACEs, social participation, and sarcopenia was evaluated using Cox proportional hazard regression models. Results The study population comprised 6859 older adults in main analyses. Having experienced ≥ 3 ACEs led to an increased 31% risk of developing sarcopenia (hazard ratio [HR]:1.31, 95% confidence interval [CI]:1.10–1.56). Participants having experienced ≥ 2 threat-related ACEs (HR:1.22, 95%CI:1.04–1.43) or deprivation-related ACEs (HR:1.22, 95%CI:1.02–1.46) had a 22% higher risk of developing sarcopenia. Active social participation significantly modified the association between ACEs (p < 0.05), especially threat-related ACEs (p < 0.05), and sarcopenia. Conclusions ACEs were associated with the development of sarcopenia; however, social participation had a modifying effect. These findings provide insights for early identification of vulnerable groups, advance intervention timing, and highlight the benefits of promoting active social participation among individuals with sarcopenia who have experienced ACEs.

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“…• Mobility limitation is an important risk factor for these conditions Takemura et al 97 • Social isolation is significantly related to death at home (OR 3.47, 95% CI 1.08-11.1) in the multivariate analysis with multiple imputation, but loneliness is not in association to overall survival or home mortality Koh-Bell et al 98 • This study is not able to identify an association between social isolation and cancer mortality (p = .54)…”

Section: Name/study Outcomesmentioning

confidence: 92%

“…97 In contrast, a study by Koh-Bell et al failed to confirm such an association. 98 Generally, studies suggest that social isolation can result in decreased therapeutic compliance, negative health conditions and mental health status, and a poor quality of life. 99 A detailed analysis by Liang et al, of the effects of social isolation and loneliness on cancer patients has been published recently.…”

Section: Name/study Outcomesmentioning

confidence: 99%

“…In a study including 211 patients with advanced lung cancer, Takemura et al reported that social isolation was independently related to death at home, but loneliness wasn't 97 . In contrast, a study by Koh‐Bell et al failed to confirm such an association 98 . Generally, studies suggest that social isolation can result in decreased therapeutic compliance, negative health conditions and mental health status, and a poor quality of life 99 .…”

Section: The Impact Of Social Isolation and Loneliness On Chronic Dis...mentioning

confidence: 99%

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Social isolation and loneliness: Undervalued risk factors for disease states and mortality

Kanbay

Tanrıöver

Çöpür

et al. 2023

Eur J Clin Investigation

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Social isolation and loneliness are two common but undervalued conditions associated with a poor quality of life, decreased overall health and mortality. In this review, we aim to discuss the health consequences of social isolation and loneliness. We first provide the potential causes of these two conditions. Then, we explain the pathophysiological processes underlying the effects of social isolation and loneliness in disease states. Afterwards, we explain the important associations between these conditions and different non‐communicable diseases, as well as the impact of social isolation and loneliness on health‐related behaviours. Finally, we discuss the current and novel potential management strategies for these conditions. Healthcare professionals who attend to socially isolated and/or lonely patients should be fully competent in these conditions and assess their patients thoroughly to detect and properly understand the effects of isolation and loneliness. Patients should be offered education and treatment alternatives through shared decision‐making. Future studies are needed to understand the underlying mechanisms better and to improve the treatment strategies for both social isolation and loneliness.

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Social isolation, inflammation, and cancer mortality from the National Health and Nutrition Examination Survey - a study of 3,360 women

Cited by 5 publications

References 39 publications

The Effect of Social Isolation on Sarcopenia: A Longitudinal Study among the Middle-Aged and Older Population in China

The Effect of Social Isolation on Sarcopenia: A Longitudinal Study among the Middle-Aged and Older Population in China

Adverse childhood experiences, sarcopenia, and social participation in older adults: a cohort study

Social isolation and loneliness: Undervalued risk factors for disease states and mortality

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