Social isolation stress enhanced liver metastasis of murine colon 26-L5 carcinoma cells by suppressing immune responses in mice

Wu, Wenjuan; Yamaura, Takeshi; Murakami, Koji; Murata, Jun; Matsumoto, Kinzo; Watanabe, Hiroshi; Saiki, Ikuo

doi:10.1016/s0024-3205(00)00506-3

Cited by 110 publications

(57 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…30) Direct support for this may come from our previous studies showing suppressed immune functions following psychosocial stress. 21) For instance, the exposure of mice to a 2-week pre-isolation resulted in decreases of thymus weight and the cell number of thymocytes, reduced the proliferative response of splenocytes to various stimuli and splenic NK activity, as well as decreased macrophage-mediated cytotoxicity. It is well known that T-lymphocytes, NK cells and macrophages are involved in the controlling of tumor invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…We have recently shown that tumor necrosis factor-a (TNF-a) was over-secreted in male BALB/c mice under social isolation, and this was closely associated with a remarkable elevation of tumor invasion, angiogenesis and metastasis of colon 26-L5 carcinoma cells. 34,35) Thus, it is conceivable that the isolation stress increased the vulnerability of mice to developing tumor metastasis in part by impairing the basal immune responses of the host and by stimulating metastasispromoting factors, like TNF-a.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Social Isolation Stress Impairs the Resistance of Mice to Experimental Liver Metastasis of Murine Colon 26-L5 Carcinoma Cells.

Murata

Hayashi

et al. 2001

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

Recently, growing epidemiological evidence suggests the importance of psychosocial factors in a wide variety of diseases such as depression, cardiovascular diseases and cancer.1-3) Social isolation, divorce and bereavement are reported to be associated with an increased risk of cancer recurrence, the probability of metastasis and mortality rates for cancer, as well as decreased efficacy of cancer therapy. [4][5][6][7] In contrast, reducing the impact of psychosocial stress through social support, including the presence of a social network or psychosocial intervention, has also been shown to be related to an increase in the survival time and a decrease in the rate of metastasis. 8,9) Experimental investigations into the effects of psychosocial factors on tumor progression in animals may provide useful information of basic values for clinical situations. Social isolation (individual housing) is a model of lack of social interactions among animals, which is relatively comparable with the situation of humans who feel isolated. In rodents, social isolation results in marked behavioral disturbances such as increased aggressiveness, enhanced locomotor activity and reduced pentobarbital-induced sleeping time, 10,11) and physiological disturbances, including high levels of plasma corticosterone, catecholamine and high activity of corticotropin releasing factor (CRF). [12][13][14] Because of its inherent social nature, social isolation is viewed as a natural and convenient model of psychosocial stress, and would be helpful for investigating the modulatory role of psychosocial stress in tumor development. Social isolation stress has been reported to accelerate the development and growth of either transplanted or chemically induced tumors, and to attenuate the response of tumors to chemotherapy. [15][16][17] However, there are also some conflicting reports on the association between tumor development and psychosocial stress in both human and animal studies, because of the variations in stress chronicity, timing of stress and types of tumors tested, etc.18,19) Nevertheless, the strong evidence indicates that the tumor progression can be affected by psychosocial factors relating to grouping and isolation, although the underlying mechanism is still unknown. Despite the advances in diagnostic techniques and therapeutic modalities for malignant tumors including colon cancer, the mortality rate of cancer is still high. 20) Many cancer patients develop recurrent and metastatic cancer even if curative surgery is undergone. Metastasis is a major cause of mortality in cancer. However, to our knowledge, the specific effects of psychosocial stress on tumor recurrence and metastasis have only been marginally studied, in spite of the crucial clinical relevance of these phenomena.We recently found that social isolation stress significantly suppressed the basal cellular immune responses and exacerbated experimental liver metastasis of colon 26-L5 carcinoma cells in male BALB/c mice.21) The immune surveillance functions of effector cells su...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Social Isolation Stress Impairs the Resistance of Mice to Experimental Liver Metastasis of Murine Colon 26-L5 Carcinoma Cells.

Murata

Hayashi

et al. 2001

Biological & Pharmaceutical Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…HE employed in this report might have imposed psychological stress due to forced treadmill running. Psychological stress is known to reduce natural killer cell activity [27,28], resulting in possible increase in cancer development. Although the long-term HE in this report showed beneficial effects on cancer suppression, the benefits might have been weakened by psychological stress.…”

Section: Discussionmentioning

confidence: 99%

Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate

Kato

Kawaguchi

Miyoshi

et al. 2010

Environ Health Prev Med

View full text Add to dashboard Cite

Objectives We investigated whether habitual exercise (HE) (treadmill running) suppresses development of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Methods Male Fischer 344 rats were divided into six groups: group I, saline treatment (12 weeks = initiation period) and non-HE; group II, Fe-NTA treatment (12 weeks) and non-HE; group III, saline treatment and short-term (12 weeks) HE; group IV, Fe-NTA treatment and short-term HE; group V, saline treatment and long-term (40 weeks) HE; and group VI, Fe-NTA treatment and long-term HE. Saline treatment groups did not develop RCC, therefore we investigated the effects of HE among Fe-NTA treatment groups.Results Gross nodules (diagnosed as RCC), RCC represented by microcarcinomas (Mcs), karyomegalic cells (KCs), and degenerative tubules (DTs) were seen in rats treated with Fe-NTA. The number of Mcs, KCs, and DTs were increased in the short-term HE group when compared with those in the non-HE group, but were decreased in the long-term HE group when compared with those in the short-term HE group. Conclusions Short-term (initiation period) HE promoted renal carcinogenesis induced by Fe-NTA; however, longterm HE after the initiation period suppressed the promoted carcinogenesis.

show abstract

“…In the same study, diclofenac also inhibited the hyperalgesia at the early phases (during the first three weeks post-inoculation) indicating the relevant contribution of inflammatory mechanisms in the mediation of tumorinduced hyperalgesic responses. Considering the additional experimental evidence that different types of stress may suppress immunity and enhance cancer growth and metastatic spread (74)(75)(76)(77)(78), as well as additional evidence indicating that morphine analgesia attenuates surgery-induced enhancement of metastatic colonization in rats (79), it is arguable that effective relief from pain by medication or neural blockade in cancer patients in addition to improving comfort and quality of life, does have the capacity to inhibit tumor expansion and metastatic spread as well. Biphosphonates Biphosphonates relieve pain from metastases to bones.…”

Section: Opioidsmentioning

confidence: 99%

Advances in the therapy of cancer pain: from novel experimental models to evidence-based treatments

2007

View full text Add to dashboard Cite

Social isolation stress enhanced liver metastasis of murine colon 26-L5 carcinoma cells by suppressing immune responses in mice

Cited by 110 publications

References 36 publications

Social Isolation Stress Impairs the Resistance of Mice to Experimental Liver Metastasis of Murine Colon 26-L5 Carcinoma Cells.

Social Isolation Stress Impairs the Resistance of Mice to Experimental Liver Metastasis of Murine Colon 26-L5 Carcinoma Cells.

Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate

Advances in the therapy of cancer pain: from novel experimental models to evidence-based treatments

Contact Info

Product

Resources

About