Social Jetlag, Chronotype, and Cardiometabolic Risk

Wong, Patricia; Hasler, Brant P.; Kamarck, Thomas W.; Muldoon, Matthew F.; Manuck, Stephen B.

doi:10.1210/jc.2015-2923

Cited by 358 publications

(318 citation statements)

References 51 publications

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“…These changes were found to be independent of changes in sleep duration (Leproult et al, 2014). In a population-based study, evening chronotype, which is typically associated with a mild form of circadian misalignment, has been associated with metabolic syndrome (Yu et al, 2015), type 2 diabetes (Merikanto et al, 2013;Yu et al, 2015) and lower HDL cholesterol (Wong et al, 2015).…”

Section: Discussionmentioning

confidence: 89%

Later chronotype is associated with higher hemoglobin A1c in prediabetes patients

Anothaisintawee

Lertrattananon

Thamakaison

et al. 2017

Chronobiology International

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The circadian system is known to play a role in glucose metabolism. Chronotype reflects the interindividual variability in the phase of entrainment. Those with later chronotype typically prefer later times in the day for different activities such as sleep or meals. Later chronotype has been shown to be associated with metabolic syndrome, increased diabetes risk and poorer glycemic control in type 2 diabetes patients. In addition, "social jetlag", a form of circadian misalignment due to a mismatch between social rhythms and the circadian clock, has been shown to be associated with insulin resistance. Other sleep disturbances (insufficient sleep, poor sleep quality and sleep apnea) have also been shown to affect glucose metabolism. In this study, we explored whether there was a relationship between chronotype, social jetlag and hemoglobin A1c (HbA1c) levels in prediabetes patients, independent of other sleep disturbances. A cross-sectional study was conducted at the Department of Family Medicine, Ramathibodi Hospital, Bangkok, from October 2014 to March 2016 in 1014 non-shift working adults with prediabetes. Mid-sleep time on free day adjusted for sleep debt (MSFsc) was used as an indicator of chronotype. Social jetlag was calculated based on the absolute difference between mid-sleep time on weekdays and weekends. The most recent HbA1c values and lipid levels were retrieved from clinical laboratory databases. Univariate analyses revealed that later MSFsc (p = 0.028) but not social jetlag (p = 0.48) was significantly associated with higher HbA1c levels. Multivariate linear regression analysis was applied to determine whether an independent association between MSFsc and HbA1c level existed. After adjusting for age, sex, alcohol use, body mass index (BMI), social jetlag, sleep duration, sleep quality and sleep apnea risk, later MSFsc was significantly associated with higher HbA1c level (B = 0.019, 95% CI: 0.00001, 0.038, p = 0.049). The effect size of one hour later MSFsc on HbA1c (standardized coefficient = 0.065) was approximately 74% of that of the effect of one unit (kg/m 2 ) increase in BMI (standardized coefficient = 0.087). In summary, later chronotype is associated with higher HbA1c levels in patients with prediabetes, independent of social jetlag and other sleep disturbances. Further research regarding the potential role of chronotype in diabetes prevention should be explored. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 89%

Later chronotype is associated with higher hemoglobin A1c in prediabetes patients

Anothaisintawee

Lertrattananon

Thamakaison

et al. 2017

Chronobiology International

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“…In addition, irregular eating patterns and reduced daylight exposure are also common lifestyles changes in the modern 24/7 society [6, 7]. There is convincing evidence that all these lifestyle changes contribute to circadian (see glossary) disturbances [8-10]. Recently, accumulating epidemiological evidence has indicated that circadian disturbances in the forms of shift work [11, 12], late meal timing [6], late chronotype [13, 14], social jet lag [15], and sleep loss [16] are associated with increased risks of T2D.…”

Section: Lifestyle Changes Relevant To Circadian Disturbances and mentioning

confidence: 99%

Circadian System and Glucose Metabolism: Implications for Physiology and Disease

Qian

Scheer

2016

Trends in Endocrinology & Metabolism

277

190

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The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-hr rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important in regulating the daily rhythm in glucose metabolism. Disturbance of this circadian control or of its coordination relative to the environmental/behavioral cycle, such as in shift work, eating late or due to genetic changes, results in disturbed glucose control and increased type 2 diabetes risk. Therefore, an in-depth understanding of the mechanisms underlying glucose regulation by the circadian system and its disturbance may help in the development of therapeutic interventions against the deleterious health consequences of circadian disruption.

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“…Although sleep disturbances are known to affect health and behavior, 6 we cannot presume a direct causal relationship between such outcomes and SJL, which appears mostly as a variable that characterizes the study samples. Thus, we chose to exclude studies that did not explicitly assess illness Levandovski et al 2011 29 Roenneberg et al 2012 21 Johnsen et al 2013 22 Kantermann et al 2013 27 Schimitt et al 2013 35 Haraszti et al 2014 40 Kantermann et al 2014 25 Miller et al 2015 44 Rutters et al 2014 28 Borisenkov et al 2015 32 Parsons et al 2015 35 Tavernier et al 2015 42 Wong et al 2015 26 Choi et al 2016 45 Kolomeichuk et al 2016 38 Polugrudov et al 2016 24 Sheaves et al 2016 30 Silva et al 2016 46 Yong states or behavioral outcomes. Furthermore, it is very likely that sleep deficit correlates with SJL.…”

Section: Excluded Studies and Terminologymentioning

confidence: 99%

“…Kantermann et al 25 found no association between SJL and metabolic risk parameters in male shift workers, which may be due to the small sample size. However, Parsons et al 23 found that individuals with higher SJL were more likely to meet the criteria for metabolic syndrome and Wong et al 26 found higher cardiometabolic risk markers associated with higher SJL in larger samples of both sexes. Regarding the risk of cardiovascular pathologies, a positive correlation between SJL and heart rate has been demonstrated.…”

Section: Summary Of Findingsmentioning

confidence: 99%

Social jetlag in health and behavioral research: a systematic review

Beauvalet¹,

Quiles²,

Oliveira³

et al. 2017

CPT

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Social Jetlag, Chronotype, and Cardiometabolic Risk

Abstract: Our findings suggest that a misalignment of sleep timing is associated with metabolic risk factors that predispose to diabetes and atherosclerotic cardiovascular disease.

Cited by 358 publications

References 51 publications

Later chronotype is associated with higher hemoglobin A1c in prediabetes patients

Later chronotype is associated with higher hemoglobin A1c in prediabetes patients

Circadian System and Glucose Metabolism: Implications for Physiology and Disease

Social jetlag in health and behavioral research: a systematic review

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