Publications are commonly used to evaluate the productivity and impact of research programs. Traditional metrics examine publication impact through slowly accumulating academic citations. "Altmetrics" are a new way to describe early publication influence in nonacademic media/community spheres (news, tweets, and blogs). Articles with significant altmetric attention make a big splash of im-How to cite this article: Llewellyn NM, Nehl EJ. Predicting citation impact from altmetric attention in clinical and translational research: Do big splashes lead to ripple effects?