Social modulation of ageing: mechanisms, ecology, evolution

Quigley, Tyler P.; Amdam, Gro V.

doi:10.1098/rstb.2019.0738

Cited by 10 publications

(7 citation statements)

References 217 publications

(255 reference statements)

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“…A role for peroxiredoxins also became evident in several other transcriptome studies in this volume [30,32,33]. Furthermore, Quigley & Amdam [49] also stress the importance of social interactions in modulating senescence in humans, similar to what has been shown in social insects and social rodents [33,40,43,46,47].…”

Section: Contributionsmentioning

confidence: 52%

“…The final paper by Quigley & Amdam [49] comparatively reviews studies on the mechanism of ageing in social Hymenoptera and humans. Like several of the former papers, this focuses on oxidative stress and identifies striking similarities, such as the role of peroxiredoxins, antioxidant enzymes, which in mammals appear to play a protective role in neurodegenerative disorders involving stress and seem to improve brain function in old honeybees.…”

Section: Contributionsmentioning

confidence: 99%

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Ageing and sociality: why, when and how does sociality change ageing patterns?

Korb

Heınze

2021

Phil. Trans. R. Soc. B

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Individual lifespans vary tremendously between and also within species, but the proximate and ultimate causes of different ageing speeds are still not well understood. Sociality appears to be associated with the evolution of greater longevity and probably also with a larger plasticity of the shape and pace of ageing. For example, reproductives of several termites and ants reach lifespans that surpass those of their non-reproductive nestmates by one or two decades. In this issue, 15 papers explore the interrelations between sociality and individual longevity in both, group-living vertebrates and social insects. Here, we briefly give an overview of the contents of the various contributions, including theoretical and comparative studies, and we explore the similarities and dissimilarities in proximate mechanisms underlying ageing among taxa, with particular emphasis on nutrient-sensing pathways and, in insects, juvenile hormone. These studies point to an underestimated role of more downstream processes. We highlight the need for reliable transcriptomic markers of ageing and a comprehensive ageing theory of social animals, which includes the reproductive potential of workers, and considers the fact that social insect queens reach maturity only after a prolonged period of producing non-reproductive workers. This article is part of the theme issue ‘Ageing and sociality: why, when and how does sociality change ageing patterns?’

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Section: Contributionsmentioning

confidence: 52%

Section: Contributionsmentioning

confidence: 99%

Ageing and sociality: why, when and how does sociality change ageing patterns?

Korb

Heınze

2021

Phil. Trans. R. Soc. B

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“…Such study systems might also offer important insight into ageing interventions (e.g. [177]) or present new possibilities for disentangling causal relationships between social, physical, cognitive and physiological ageing [172,[178][179][180]. Here, we have laid out several clear explanations for social ageing based on expected physical, cognitive, experiential, demographic and reproductive changes that occur across an individual's lifespan.…”

Section: §2c(ii) Kinship Dynamicsmentioning

confidence: 99%

Social ageing: exploring the drivers of late-life changes in social behaviour in mammals

et al. 2022

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Social interactions help group-living organisms cope with socio-environmental challenges and are central to survival and reproductive success. Recent research has shown that social behaviour and relationships can change across the lifespan, a phenomenon referred to as ‘social ageing’. Given the importance of social integration for health and well-being, age-dependent changes in social behaviour can modulate how fitness changes with age and may be an important source of unexplained variation in individual patterns of senescence. However, integrating social behaviour into ageing research requires a deeper understanding of the causes and consequences of age-based changes in social behaviour. Here, we provide an overview of the drivers of late-life changes in sociality. We suggest that explanations for social ageing can be categorized into three groups: changes in sociality that (a) occur as a result of senescence; (b) result from adaptations to ameliorate the negative effects of senescence; and/or (c) result from positive effects of age and demographic changes. Quantifying the relative contribution of these processes to late-life changes in sociality will allow us to move towards a more holistic understanding of how and why these patterns emerge and will provide important insights into the potential for social ageing to delay or accelerate other patterns of senescence.

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“…Accordingly, we identified significant enrichment for oxidation-reduction processes across old individuals regardless of phenotypic class (electronic supplementary material, table S5). An ability to mitigate oxidative damage has been consistently and independently implicated as critical to the longevity of many aerobic taxa, from bivalves [79] to humans, mammals and birds [80][81][82], and among social insects [17,83,84]. Among advanced eusocial bees, older foragers may offset oxidative damage through increased expression of redox-related proteins, such as catalase [83].…”

Section: (C) Molecular Signatures Of Longevity In Ceratina Japonicamentioning

confidence: 99%

Social divergence: molecular pathways underlying castes and longevity in a facultatively eusocial small carpenter bee

Shell

Rehan

2022

Proc. R. Soc. B.

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Unravelling the evolutionary origins of eusocial life is a longstanding endeavour in the field of evolutionary-developmental biology. Descended from solitary ancestors, eusocial insects such as honeybees have evolved ontogenetic division of labour in which short-lived workers perform age-associated tasks, while a long-lived queen produces brood. It is hypothesized that (i) eusocial caste systems evolved through the co-option of deeply conserved genes and (ii) longevity may be tied to oxidative damage mitigation capacity. To date, however, these hypotheses have been examined primarily among only obligately eusocial corbiculate bees. We present brain transcriptomic data from a Japanese small carpenter bee, Ceratina japonica (Apidae: Xylocopinae), which demonstrates both solitary and eusocial nesting in sympatry and lives 2 or more years in the wild. Our dataset captures gene expression patterns underlying first- and second-year solitary females, queens and workers, providing an unprecedented opportunity to explore the molecular mechanisms underlying caste-antecedent phenotypes in a long-lived and facultatively eusocial bee. We find that C. japonica 's queens and workers are underpinned by divergent gene regulatory pathways, involving many differentially expressed genes well-conserved among other primitively eusocial bee lineages. We also find support for oxidative damage reduction as a proximate mechanism of longevity in C. japonica .

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Social modulation of ageing: mechanisms, ecology, evolution

Cited by 10 publications

References 217 publications

Ageing and sociality: why, when and how does sociality change ageing patterns?

Ageing and sociality: why, when and how does sociality change ageing patterns?

Social ageing: exploring the drivers of late-life changes in social behaviour in mammals

Social divergence: molecular pathways underlying castes and longevity in a facultatively eusocial small carpenter bee

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