The world of work is transforming, driven by insights from the frontiers of science. Human resource (HR) practices are no longer limited to traditional methods and increasingly incorporate knowledge from disciplines like Cognitive Behavioral Neuroscience (CBN). By understanding how our brains work, we can design HR practices that enhance employee well-being, engagement, and, ultimately, performance. Drawing from neuroscientific research on decision-making, communication, stress, learning, motivation, and workplace design, this chapter delves into the intersection of CBN and HR, offering evidence-based practices that support a thriving workforce. This interdisciplinary approach holds promise for maximizing human potential in the context of the modern workplace.