Social odours, hormone modulation and resistance to disease in male laboratory mice,Mus musculus

Smith, F. V.; Barnard, C. J.; Behnke, Jerzy M.

doi:10.1006/anbe.1996.0160

Cited by 35 publications

(43 citation statements)

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“…The impairments of the KO mice also cannot be attributed to differences in basal testosterone levels in that the various WTs and KOs examined here are reported to display similar basal testosterone levels (Ogawa et al, 1998Nomura et al, 2002Nomura et al, , 2006. Furthermore, increases in testosterone levels in male mice generally occur 15-30 min after exposure to females or their odors (Coquelin and Desjardins, 1982;Smith et al, 1996; suggesting that the emboldening responses seen 1 min after exposure to female odor are not directly associated with changes in testosterone. The testosterone responses of men to brief interaction with women or their cues are suggested to follow similar temporal patterns (Roney et al, , 2007.…”

Section: Discussionmentioning

confidence: 65%

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Kavaliers

Devidze

Choleris

et al. 2008

Psychoneuroendocrinology

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SummaryMale risk taking and decision making are affected by sex-related cues, with men making poorer and riskier decisions in the presence of females and, or their cues. In non-human species, female cues can also increase male risk taking, reducing their responses to predator threat. As estrogen receptors α and β (ERα and ERβ) are involved in the mediation of social and sexual responses, we investigated their roles in determining the effects of female-associated cues on male risk taking. We examined the effects of brief pre-exposure to the odors of either a novel or familiar estrous female on the avoidance of, and aversive responses to, predator threat (cat odor) in ERα and ERβ wild type (αERWT, βERWT) and gene-deleted (knockout, αERKO, βERKO) male mice. Exposure of αERWT and βERWT males to the odors of a novel, but not a familiar, estrous female mouse resulted in enhanced risk taking with the males displaying reduced avoidance of, and analgesic responses to, cat odor. In contrast, αERKO male mice failed to show any changes in risk taking, while βERKO males, although displaying greater risk taking, did not distinguish between novel and familiar females, displaying similarly reduced avoidance responses to cat odor after exposure to either a novel or familiar female odor. These findings indicate that the gene for ERα is associated with the sexual mechanisms (response to estrous female) and the genes for ERβ and ERα with the social (recognition of novel female) mechanisms underlying the effects of female cues on male risk taking. *Corresponding author. kavalier@uwo.ca (M. Kavaliers).

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Section: Discussionmentioning

confidence: 65%

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Kavaliers

Devidze

Choleris

et al. 2008

Psychoneuroendocrinology

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“…In a series of experiments with male laboratory mice of the CFLP strain, we have shown that aggressive behaviour and serum hormone (testosterone and corticosterone) and total IgG [a bystander measure of immunocompetence (4-6)] concentrations covary in ways that are consistent with the adaptive modulation hypothesis and influence resistance to an experimental infection of the piroplasmid protozoan Babesia microti (3)(4)(5)(6)32). Moreover, interrelationships differ between males of different social status and between social/sexual contexts in accordance with rank-related modulation of hormone secretion and an adaptive trade-off between immunocompetence and apparent reproductive opportunity (2,5,32).…”

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confidence: 68%

“…RECENT discussions have suggested that immune function has an important influence on physiological and behavioural decision-making [e.g., (6,14,26,32,35)]. In particular, several hormones and cytokines from the gonads and adrenal, thyroid, thymus, pituitary, and pineal glands interact directly or indirectly with the immune system [e.g., (1,14,30,31)], with the effect that some components of the immune response may become downregulated.…”

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confidence: 99%

“…More recently, such mechanisms have been viewed as an element in the adaptive modulation of hormone secretion, behaviour, and morphological (particularly secondary sexual) characters, where these have consequences for immunocompetence [(5,14,32,35), but see (27)]. In this view, immunocompetence may be conserved (by downregulating hormone secretion) and, thus, act as a constraint on other categories of decision-making (e.g., sexual display), or immunodepression may be tolerated and reflect an adaptive life history decision to shift metabolic resources between physiological systems, with immunodepressive hormones providing part of the mechanism for regulating investment in immune function (5,32,35).…”

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confidence: 99%

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Modulation of Behaviour and Testosterone Concentration in Immunodepressed Male Laboratory Mice (Mus musculus)

Barnard

Behnke

Gage

et al. 1997

Physiology & Behavior

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. Modulation of behaviour and testosterone concentration in immunodepressed male laboratory mice (Mus musculus). PHYSIOL BEHAV 61(6) 907-917, 1997.-Recent ideas suggest that current immunocompetence may act as a constraint on behavioural and physiological decisions, where these risk imposing an additional burden on immune function. We tested this in the context of time budgeting and the secretion of the potentially immunodepressive hormones testosterone and corticosterone, by treating adult male CFLP laboratory mice with antithymocyte serum (ATS) to depress thymus-mediated immune function. In comparison with males given a naive rabbit serum (NRS) vehicle control, ATS-treated mice showed a reduction in serum testosterone concentration, aggressive behaviour, and general activity, and maintained time spent sleeping, relative to pretreatment levels. Behaviours that differed between treatments correlated with measures of immunodepression (reduction in relative thymus weight or serum total IgG concentration), but relationships with behavioural changes were independent of those with testosterone. There was little evidence that changes were affected by social status. The results are discussed in the context of the adaptive modulation of immune function and physiological and behavioural decision-making. ᭧ 1997 Elsevier Science Inc.

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“…The first answer to this question comes from the study of Smith et al [123]. They showed that regular presentation of soiled bedding from other mice, especially from females, suppresses male resistance to infection.…”

Section: Immunosuppressive Effects Of Sexual Chemical Signalsmentioning

confidence: 99%

The Role of the Immune System in Behavioral Strategies of Reproduction

Мошкин

Gerlinskaya

Evsikov

2000

Journal of Reproduction and Development

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Abstract. Since both reproduction and immunocompetence are costly, the negative reciprocal relationships between these functions were found in many species. Due to reproductive immunosuppression, some fraction of seasonally breeding populations of small mammals reproduces in the first breeding season, while others reproduce in the next one. Elevation of breeding efforts under the increased risk of mortality and the reproductive delay until recovery are the polar variants of mating behavior of parasitized individuals. However the parasite-induced changes of odor, visual or acoustic signals limit the mating success of the infected hosts. The direct influence of the immune system, regularly activated by infections, to chemicals signals can be answer to the question: why these signals are honest? Decrease of a strange infection risk by kin breeding can be a satisfactory strategy of an isolated population. Nevertheless, many species follow the inbreeding avoidance strategy, where the major histocompatibility complex (MHC) genes play key role in kin recognition. The advantage of MHC heterozygosity was found at the all steps of the breeding cycle; including mating choice, fertilization, pre-and postnatal development. So, the relationships between immune system and neuroendocrine regulation of behavior give proximate explanations of the evolutionary stable strategies of breeding behavior.

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Social odours, hormone modulation and resistance to disease in male laboratory mice,Mus musculus

Cited by 35 publications

References 0 publications

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

Modulation of Behaviour and Testosterone Concentration in Immunodepressed Male Laboratory Mice (Mus musculus)

The Role of the Immune System in Behavioral Strategies of Reproduction

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