Social Preferences of Developing Guinea Pigs (Cavia porcellus) From the Preweaning to the Periadolescent Periods.

Hennessy, Michael B.; Young, Travis L.; O’Leary, Shonagh K.; Maken, Deborah S.

doi:10.1037/0735-7036.117.4.406

Cited by 21 publications

(17 citation statements)

References 36 publications

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“…Interestingly, it has been observed in other rodents, such as guinea pigs, that pups prefer being in proximity of the mothers rather than other adults (Hennessy et al 2003) although they would also explore other female adult conspecific (Graves & Hennessy 2000) and the presence of the mother is more effective in lowering stress levels, compared with other female adults, when the pup is placed in a novel environment. Attachment has been also widely explored, in the rat, by Regina Sullivan's group.…”

Section: Discussionmentioning

confidence: 99%

Gene‐environment interaction influences attachment‐like style in mice

Lassi

Tucci

2017

Genes Brain and Behavior

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Attachment styles are established soon after birth and form the basis for a healthy psychological life during adulthood. Here, we investigated whether genetic background (i.e. isogenic strains: C57BL/6N and BALB/c) and parent-of-origin (i.e. reciprocal hybrids) epigenetic effects influence attachment-like styles in mice. We discovered that a specific genetic and epigenetic assortment exerts a role on the development of a secure or insecure attachment-like style. In particular, when biological mothers raise their pups, the attachment-like style is mainly secure, independently of the genetic background. However, when foster mothers raise pups, the attachment-like style can be either secure or insecure, depending on the particular genetic background, and this effect is paternally transmitted. Finally, we observed that secure attachment-like in mice leads to greater sociability during adulthood, while insecure attachment-like leads to reduced sociability. Our study sheds light on gene-environment interactions that shape the attachment-like style early in development and pave the way for a healthy psychological life.

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Section: Discussionmentioning

confidence: 99%

Gene‐environment interaction influences attachment‐like style in mice

Lassi

Tucci

2017

Genes Brain and Behavior

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“…Testing was conducted near the time of natural weaning, which occurs around Day 25 (König, 1985; Schiml & Hennessy, 1990). At this age, guinea pigs show a strong attraction to the mother, as well as robust active and passive behavioral responses to separation (e.g., Hennessy, Young, O'Leary, & Maken, 2003; Hennessy et al, 1995). …”

Section: General Methodsmentioning

confidence: 99%

Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.

Hennessy¹,

Paik²,

Caraway³

et al. 2011

Behavioral Neuroscience

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When guinea pig pups are isolated for a few hours in a novel environment, they exhibit a distinctive passive behavioral response that appears to be mediated by proinflammatory activity. Recently, we observed that pups separated on two consecutive days show an enhanced (sensitized) passive response on the second day. In Experiment 1, pups receiving intracerebroventricular infusion of 50 ng of the anti-inflammatory cytokine Interleukin-10 prior to a first separation failed to show a sensitized behavioral response to separation the next day. In Experiment 2, pups separated on Days 1 and 2, or just 2, showed an increase in passive responding during separation on Day 5. Pups injected with the bacterial antigen lipopolysacchride (LPS; 75μg/kg body weight, intraperitoneal) prior to separation on Day 1 showed an increase in passive behavior several days later not shown by pups injected with saline prior to Day 1 separation. However, injection of LPS without separation on the first day did not enhance responding during an initial separation on the second day. These results suggest that immune activation is necessary, but not sufficient, to account for the sensitization of passive behavior of isolated guinea pig pups the following day, that boosting proinflammatory activity during an initial separation may promote sensitization several days later, and that the sensitized response persists for at least several days. Keywords maternal separation; sensitization; passive behavior; sickness behavior; depressive-like behavior; cytokines; proinflammatory; Interleuken-10; lipopolysacchride; guinea pig Stressful life experiences alter the activity of diverse neural and endocrine systems. Prominent among these changes are increases in activity of the hypothalamic-pituitaryadrenal (HPA) axis, sympathetic nervous system, amygdala, locus coeruleus, and extrahypothalamic corticotropin-releasing factor (CRF) pathways (Stratakis & Chrousos, 1995;Rodrigues, LeDoux, & Sapolsky, 2009). In the past few decades, it has become clear that stressors also can activate proinflammatory signaling, resulting in physiological and behavioral responses similar to those of physically ill animals (e.g., altered production of liver proteins, fever, reduced responsiveness to the environment, sleepiness, postures that Black, 2003; Kubera, Holan, Mathison, & Maes, 2010;Maier & Watkins, 1998). The physiological reactions induced by stressors have been associated with various forms of psychopathology. For instance, episodes of adult depression often coincide with, or follow, periods of severe or prolonged stress (Bonde, 2008;Caspi et al., 2003;Chadda, Malhotra, Kaw, Singh, & Sethi, 2007).Similar effects have been observed in children. Following isolation from primary caretakers, as was common practice in hospitals and other institutions in the middle of the last century, some children eventually lapse into a depressive-like state (i.e., "anaclitic depression") characterized by weepiness and emotional withdrawal (Spitz, 1946). Moreover, early stressors,...

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“…The audible ''whistles'' that pups produce during isolation seem to serve as contact calls (Berryman, 1981). Once contact is established, either pup or mother may approach the other (Hennessy, Young, O'Leary, & Maken, 2003;King, 1956). Thus, if potentiation serves solely as a means of eliciting retrieval, no potentiation would be expected in guinea pig pups.…”

Section: Introductionmentioning

confidence: 91%

“…On the one hand, since precocial young are less dependent on the mother, detection of any familiar, amicable conspecific might be sufficient to potentiate behavior. On the other hand, since pups appear to readily discriminate their mother from other lactating and nonlactating females (Hennessy & Ritchey, 1987;Hennessy et al, 2003;Jackel & Trillmich, 2003;Pettijohn, 1979), it is also possible that only the pup's own mother would be an effective stimulus to elicit a potentiated response.…”

Section: Introductionmentioning

confidence: 97%

Brief exposure to the biological mother “potentiates” the isolation behavior of precocial Guinea pig pups

2006

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When isolated rat pups are briefly reunited with a lactating female, her subsequent removal leads to a dramatic increase in the emission of ultrasonic vocalizations, but not other behaviors. Whether this socially induced augmentation of isolation behavior (i.e., "potentiation") is characteristic only of altricial rodents is not known. Therefore, we examined precocial guinea pig pups in a potentiation paradigm. Ten-day-old guinea pigs were isolated in a test cage for 10 min, at which time they were then placed into a second cage for 5 min that either contained a companion or, for controls, was empty. Pups were then isolated again in the test cage for a second 10-min period. Control pups showed a significant reduction in vocalizing and locomotor activity from the first to second isolation period. Exposure to the biological mother prevented the decline in both behaviors (Experiment 1), whereas exposure to a familiar littermate (Experiment 2) had no effect, and exposure to an unfamiliar lactating female (Experiment 3) had only a minimal effect on locomotor activity. The results show that potentiation of isolation behaviors is not limited to altricial rodents, and suggest that specific characteristics of the effect (i.e., its magnitude, the specific behaviors affected, and the selectivity of the response to particular social partners) varies with the abilities and requirements of the young, as well as the behavioral ecology of the species in question.

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Social Preferences of Developing Guinea Pigs (Cavia porcellus) From the Preweaning to the Periadolescent Periods.

Cited by 21 publications

References 36 publications

Gene‐environment interaction influences attachment‐like style in mice

Gene‐environment interaction influences attachment‐like style in mice

Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.

Brief exposure to the biological mother “potentiates” the isolation behavior of precocial Guinea pig pups

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