Social status in mouse social hierarchies is associated with variation in oxytocin and vasopressin 1a receptor densities

Lee, Won; Hiura, Lisa C.; Yang, Eilene; Broekman, Katherine A.; Ophir, Alexander G.; Curley, James P.

doi:10.1016/j.yhbeh.2019.06.015

Cited by 42 publications

(31 citation statements)

References 99 publications

(129 reference statements)

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“…Although this data contrasts with ours, we have to keep in mind that i) the regulation of aggression within the LS, via OXTRs and V1aRs, might be underlined by sex-and speciesdependent mechanisms, as males and females 34 , as well as mice and rats 32,34 , differ in their receptor binding, (ii) we investigated the role of V1aRs, but not V1bRs and differential effects on aggression are likely, and iii) the involvement of endogenous AVP acting on V1bRs has not been shown 56 . Based on our finding that V1aR activation increases sIPSCs frequency exclusively in the dLS, we could hypothesize that V1aR activation might overrule V1bR effects by inhibiting V1bR-responsive interneurons, thereby decreasing aggression.…”

Section: Discussioncontrasting

confidence: 92%

“…In agreement, high aggression displayed by dominant males has also been linked to reduced septal AVP signaling, i.e. alpha male mice showed decreased V1aR binding in the LS, when compared to subordinate males 32 , and synthetic AVP was able to flatten dominant behavior in rhesus macaques 58 . In lactating females, the link between AVP and aggression seems to be complex as well.…”

Section: Discussionmentioning

confidence: 54%

“…For example, in male Wistar rats attenuated 21 as well as increased 22 release of AVP have been described during the display of abnormal and high 31 levels of aggression, respectively. Regarding the role of the septal OXT system, increased OXT receptor (OXTR) binding has been reported in both dominant male mice 32 and lactating female rats 33 .…”

Section: Introductionmentioning

confidence: 99%

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Concerted but segregated actions of oxytocin and vasopressin within the ventral and dorsal lateral septum determine female aggression

Oliveira

Lukas

Wolf

et al. 2020

Preprint

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In contrast to males, aggression in females has been rarely studied. Here, we established a rat model of enhanced female aggression using a combination of social isolation and aggression-training to specifically investigate the involvement of the oxytocin (OXT) and vasopressin (AVP) systems within the lateral septum (LS). Using neuropharmacological, optogenetic, chemogenetic as well as microdialyses approaches, we revealed that enhanced OXT release within the ventral LS (vLS), combined with reduced AVP release within the dorsal LS (dLS), are required for female aggression. Accordingly, increased excitability of OXT-responsive neurons in the vLS and decreased excitability of AVP-responsive neurons in the dLS were essential to evoke female aggression. Finally, in vitro activation of OXT receptors in the vLS increased tonic GABAergic inhibition of dLS neurons. Overall, our data demonstrate that septal release of OXT and AVP affects female aggression by differential regulation of the excitatory-inhibitory balance within subnetworks of the LS.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Concerted but segregated actions of oxytocin and vasopressin within the ventral and dorsal lateral septum determine female aggression

Oliveira

Lukas

Wolf

et al. 2020

Preprint

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“…Hierarchical rank has extensive effects on physical and mental health [3][4][5] and therefore could become maladaptive due to the risk factors associated with living in a particular rank. Previous research has shown extensive effects of rank on behaviour, including reproductive success [6], anxiety [7] (but see [8]), social motivation [9] and social contact [10], as well as on gene expression [7] and receptor expression [11].…”

Section: Introductionmentioning

confidence: 99%

What it takes to be at the top: The interrelationship between chronic social stress and social dominance

Šabanović

Mlambo

et al. 2020

Preprint

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AbstractDominance hierarchies of social animal groups are influenced by complex factors such as stress. Stress experienced by an animal prior to social interactions with a conspecific may be a determinant of their future social dynamics. Additionally, long-term occupancy of a specific hierarchical rank can have psychophysiological effects, leading to vulnerability to future stress.The current study aimed to delineate differential effects of stress acting before or after hierarchy formation. Using the chronic social defeat stress (CSDS) paradigm we performed behavioural investigations to determine whether exposure to CSDS before hierarchy formation predicted the new dominance status. Moreover, in another study we investigated whether social rank predicted stress vulnerability.We found that CSDS did not impede the establishment of dominance in new hierarchies as both stress-susceptible (socially avoidant) and –resilient (social) mice were able to attain dominant ranks. In contrast, within newly established hierarchies of stress-naïve mice, the subordinate, but not dominant, mice exhibit significantly greater avoidance of novel social targets. However, following exposure to CSDS, both lowest- and highest-ranked mice exhibit strong susceptibility to stress as measured by decreased interactions with a novel social target.These results suggest that the response to chronic social stress did not determine social rank in new cohorts, but low-status mice in newly established groups exhibited lower sociability to novel social targets. Interestingly, exposure of a hierarchical social group to chronic social stress led to stress-susceptibility in both high- and low-status mice as measured by social interaction.HighlightsStress susceptibility to chronic social defeat did not impede the establishment of dominance in new hierarchies.Subordinate mice exhibit reduced social preference after hierarchy formation.Following chronic social defeat stress, both subordinate and dominant mice exhibit susceptible-like reduction in social interaction, but dominant mice exhibit the greater decrease in social preference as compared to baseline.

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“…S6. for the David's score of each individual in the study) as previously described in Lee et al 23,85,86 . Based on David's scores (on group housing Day 6), we selected two urine donors per cohort (alpha = the highest David's score in the group, the most subordinate = the lowest David's score).…”

Section: Group Dominance Structure Emergence Of Hierarchies and Indimentioning

confidence: 99%

Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals

Lee

Dowd

Nikain

et al. 2020

Preprint

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Competent social functioning of group-living species relies on the ability of individuals to detect and utilize conspecific social cues to guide behavior. In many species, cues about an individual's identity, including social status, are conveyed through urinary proteins. Previous studies have identified numerous brain regions involved in processing these external cues, collectively referred to as the Social Decision-Making Network. However, how the brain encodes social information with respect to an individual's internal social status has not been thoroughly examined. Here we show that neuronal activity in male mice, as indicated by cFos immunoreactivity, is modulated by the social status and familiarity of the cue source and the subject's own social status. The posteroventral medial amygdala was the only brain region that responded exclusively to the social status of the cue source. Activity in other brain regions was modulated by social status. Specifically, within the brain of dominant subjects there was robust differential activity dependent on the status or familiarity of the cue source. Our results suggest that individuals perceive social cues differently depending on their social experience. These data inform further the investigation of neurobiological mechanisms underlying social-status related brain differences and how social status-associated differences influence physiology and behavior.

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Social status in mouse social hierarchies is associated with variation in oxytocin and vasopressin 1a receptor densities

Cited by 42 publications

References 99 publications

Concerted but segregated actions of oxytocin and vasopressin within the ventral and dorsal lateral septum determine female aggression

Concerted but segregated actions of oxytocin and vasopressin within the ventral and dorsal lateral septum determine female aggression

What it takes to be at the top: The interrelationship between chronic social stress and social dominance

Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals

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