Social stress does not interact with paradoxical sleep deprivation-induced memory impairment

Dametto, Mariangela; Suchecki, Deborah; Bueno, Otávio; Moreira, Karin M.; Tufik, Sérgio; Oliveira, Maria Gabriela Menezes

doi:10.1016/s0166-4328(01)00345-x

Cited by 39 publications

(18 citation statements)

References 35 publications

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“…It is of interest to note that SD impaired the contextual, but not the cued, aspects of Pavlovian fear conditioning, consistent with a recent study (Dametto et al, 2002). Given that contextual fear conditioning relies on normal hippocampal function (Kim and Fanselow, 1992;Phillips and LeDoux, 1992) and that SD interferes with other types of learning associated with the hippocampus [e.g., the Morris water maze and passive avoidance (Harris et al, 1982;Smith and Rose, 1996)], these behavioral data support the concept that SD disrupts hippocampal function.…”

Section: Discussionsupporting

confidence: 84%

Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons

et al. 2003

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Although the function of sleep remains elusive, several lines of evidence suggest that sleep has an important role in learning and memory. In light of the available data and with the prevalence of sleep deprivation (SD), we sought to determine the effect of SD on neuronal functioning. We found that the exposure of rats to 72 hr of primarily rapid eye movement SD impaired their subsequent performance on a hippocampus-dependent spatial learning task but had no effect on an amygdala-dependent learning task. To determine the underlying cellular level mechanisms of this hippocampal deficit, we examined the impact of SD on several fundamental aspects of membrane excitability and synaptic physiology in hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. We found that neuronal excitability was severely reduced in CA1 neurons but not in granule cells and that the production of long-term potentiation of synaptic strength was inhibited in both areas. Using multiple SD methods we further attempted to differentiate the effects of sleep deprivation from those associated with the nonspecific stress induced by the sleep deprivation methods. Together these data suggest that failure to acquire adequate sleep produces several molecular and cellular level alterations that profoundly inhibit hippocampal functioning.

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Section: Discussionsupporting

confidence: 84%

Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons

et al. 2003

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“…Also, in one of these studies (Graves et al, 2003) SD was imposed by a particularly low-stress method (frequent handling). A lower stress platform-over-water technique (involving simultaneous SD of multiple rats from socially stable groups in multiple-platform apparatuses) also effectively blocks contextual learning (Dametto et al, 2002). Utilizing another type of one-trial learning, one study concluded that platform-overwater SD-induced impairment in acquisition of passive avoidance learning is not secondary to stress (Stern, 1971).…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, a large platform will allow an animal to sleep normally; nevertheless, both sizes restrict locomotion. Spatial/contextual learning experiments comparing large and small platforms, however, have found mostly equivocal effects (Youngblood et al, 1997;Dametto et al, 2002), and we have found that both large and small platforms increase corticosterone levels (McDermott et al, 2003). A direct, effective way to control the adrenal stress response is to perform adrenalectomy (ADX) and exogenously replace normal levels of corticosterone.…”

Section: Introductionmentioning

confidence: 86%

“…Poor performance in the Morris water maze is caused by pre-training SD (Guan et al, 2004), posttraining SD (Smith andRose, 1996, 1997), and by continuous SD concomitant with daily training (Youngblood et al, 1997), indicating that lack of sleep interferes with the consolidation and acquisition of spatial information. In a related manner, SD interferes with consolidation and acquisition of contextual fear conditioning (Dametto et al, 2002;Graves et al, 2003;McDermott et al, 2003;Ruskin et al, 2004), in which the spatial configuration of features in the test apparatus is associated with an aversive unconditioned stimulus.…”

Section: Introductionmentioning

confidence: 99%

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Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze

et al. 2006

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“…REM sleep deprivation increased the nociceptive sensitivity to mechanical, thermal and electrical stimuli, but not to chemical stimuli (formalin test). In a recent study, Dametto et al (29) investigated the effects of REM sleep deprivation in Wistar rats over 96 h with a focus on performance in different conditioning tasks. They also assessed the nociceptive thresholds (vocalization or flinch behaviour to electrical foot shocks) as a covariate to examine their influence on learning performance.…”

Section: Animal Datamentioning

confidence: 99%

The Effects of Sleep Deprivation on Pain

Kundermann

Krieg²,

Schreiber³

et al. 2004

Pain Research and Management

178

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P atients with chronic pain syndromes often suffer from sleep disturbances (1). However, it is difficult to determine the direction of cause between pain and sleep disturbance. The usual perspective favours an arousal-augmenting function of pain, which prevents the initiation or the continuation of sleep. Alternatively, it is believed that the modulation of pain and sleep-wake regulation share common neurobiological systems, in particular the central serotoninergic one (2). Consequently, the association of pain and disturbed sleep might be a secondary phenomenon due to a common neurobiological dysfunction. Finally, a rather unusual perspective is that poor sleep can interfere with pain processing. With this latter direction of relation in mind, we have addressed the following issues by reviewing the literature with a clear focus on experimental studies. The following perspectives may help to integrate the reviewed findings. The relationship between sleep disturbances and pain assuggested by correlational data. The majority of studies on the relationship between sleep and pain were not based on an experimental design, but relied on correlations only. In this section, a brief summary of the clinical investigations is given, including their first clues concerning the influence of disturbed sleep on pain, and their limitation in deriving causal relations.2. Sleep deprivation as a methodological approach to mimic disturbed sleep and derive experimental evidence for algesic effects. A comprehensive review of animal and human studies, which used sleep deprivation as an independent variable and examined its influence on pain processing, is provided.3. Assumptions on the algesic mechanisms of sleep deprivation.Results from animals studies suggest various neurochemical changes during and after sleep deprivation, which seemed to be involved in the modulation of pain. With a focus on the serotoninergic system, sleep deprivation affects 5-hydroxytryptamine (5-HT) turnover (3), the firing rate of serotoninergic neurons in the dorsal nucleus raphé (4) and 5-HT receptor functions (5). Given the well-known pain inhibitory effects of 5-HT, these changes may be tentatively integrated into a serotoninergic model of hyperalgesic action of sleep deprivation. Chronic pain syndromes are associated with alterations in sleep continuity and sleep architecture. One perspective of this relationship, which has not received much attention to date, is that disturbances of sleep affect pain. To fathom this direction of cause, experimental human and animal studies on the effects of sleep deprivation on pain processing were reviewed. According to the majority of the studies, sleep deprivation produces hyperalgesic changes. Furthermore, sleep deprivation can counteract analgesic effects of pharmacological treatments involving opioidergic and serotoninergic mechanisms of action.The heterogeneity of the human data and the exclusive interest in rapid eye movement sleep deprivation in animals so far do not allow us to draw firm conclusions as to wheth...

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Social stress does not interact with paradoxical sleep deprivation-induced memory impairment

Cited by 39 publications

References 35 publications

Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons

Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons

Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze

The Effects of Sleep Deprivation on Pain

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