2016
DOI: 10.4049/jimmunol.196.supp.131.9
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Social stress-induced priming of innate immunity is associated with translocation of commensal lactobacilli to the spleen

Abstract: Exposure to the social disruption (SDR) stressor, which involves repeated social defeat in subordinate mice, increases serum cytokine levels, results in accumulation of CD11b+ myeloid cells in the spleen, and primes macrophages for increased cytokine and microbicidal activity. Our previous studies showed that the intestinal microbiota are necessary for SDR-enhancement of splenic macrophage microbicidal activity. The current study determined whether SDR-induced translocation of microbes to the spleen was associ… Show more

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