Social Stress, Visceral Obesity, and Coronary Artery Atherosclerosis in Female Primates

Shively, Carol A.; Register, Thomas C.; Clarkson, Thomas B.

doi:10.1038/oby.2009.74

Cited by 67 publications

(52 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study was conducted in a large, middle-aged and elderly prospective population-based sample. We observed that participants who experienced stressful events at baseline had an increased risk of developing metabolic syndrome after 6.5 years, which is consistent with previous prospective studies (Bergmann et al, 2014;Lee et al, 2014;Raikkonen et al, 2007;Troxel et al, 2005;Vitaliano et al, 2002) and pre-clinical studies in primates (Jayo et al, 1993;Shively et al, 2009). We are however the first to investigate the existence of a graded relationship (Bergmann et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

Stressful life events and incident metabolic syndrome: the Hoorn study

Rutters

Pilz

Koopman

et al. 2015

Stress

View full text Add to dashboard Cite

Stressful life events are associated with the metabolic syndrome in cross-sectional studies, but prospective studies addressing this issue are rare and limited. We therefore evaluated whether the number of stressful life events is associated with incident metabolic syndrome. We assessed the association between the number of stressful life events experienced in the 5 years up until baseline and incident metabolic syndrome after 6.5 years at follow-up in the Hoorn study, a middle-aged and elderly population-based cohort. Participants with prevalent metabolic syndrome at baseline were excluded. Metabolic syndrome was defined according to the Adult Treatment Panel III, including fasting plasma glucose levels, HDL-C levels, triglyceride levels, waist circumference and hypertension. We included 1099 participants (47% male; age 60 ± 7 years). During 6.5 years of follow-up, 238 participants (22%) developed the metabolic syndrome. Logistic regression adjusted for age, sex, education level and follow-up duration showed a positive association between the number of stressful life events at baseline and incident metabolic syndrome [OR 1.13 (1.01-1.27) per event, p = 0.049]. In addition, a Poisson model showed a significant positive association between the number of stressful life events at baseline and the number of metabolic syndrome factors at follow-up [OR 1.05 (1.01-1.11) per event, p = 0.018]. Finally, we observed a significant association between the number of stressful life events at baseline and waist circumference at follow-up [adjusted for confounders β 0.86 (0.39-1.34) cm per event, p < 0.001]. Overall, we concluded that persons who reported more stressful life events at baseline had a significantly increased risk for developing metabolic syndrome during 6.5 years of follow-up, in a middle-aged and elderly population-based cohort.

show abstract

Section: Discussionsupporting

confidence: 92%

Stressful life events and incident metabolic syndrome: the Hoorn study

Rutters

Pilz

Koopman

et al. 2015

Stress

View full text Add to dashboard Cite

show abstract

“…Accordingly, it remains to be investigated if DOM mice might develop other stress-associated diseases despite being metabolically healthy. This conclusion is supported by accumulating evidences for a physiological 'cost of being dominant' in naturalistic and semi-naturalistic settings (Shively et al, 2009, Sapolsky 2005, Bartolomucci et al, 2005, Gesquiere et al, 2012.…”

Section: Dominant Mice Are Resilient To Stress-induced Mets and T2dsupporting

confidence: 59%

“…Most mammals live in societies, social hierarchies are widespread, and positive and negative social relationships as well as the socioeconomic status affect mood and parallel disease/well-being. In this scenario, dominance or high socioeconomic status are often associated with priority of access to resources and are considered protective for the development of a number of pathologies (Tamashiro et al, 2007, Shively et al, 2009, Sapolsky 2005, Bartolomucci et al, 2005, Gesquiere et al, 2012. This is particularly true under stable conditions or wealthy societies (Shively et al, 2009, Sapolsky 2005, Bartolomucci et al, 2005, Gesquiere et al, 2012.…”

Section: Dominant Mice Are Resilient To Stress-induced Mets and T2dmentioning

confidence: 96%

Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome

Sanghez¹,

Razzoli²,

Carobbio³

et al. 2013

Psychoneuroendocrinology

View full text Add to dashboard Cite

“…As in people, obesity is associated with type two diabetes in Old World monkeys (Wagner et al 2006;Chavez et al 2009). Central fat deposition patterns are associated with social stress as well as carotid and coronary artery atherosclerosis in cynomolgus monkeys and with cardiovascular disease in people (Shively et al 2009). Finally, Old World monkeys are optimal models for investigations involving cognitive decline and Alzheimer's disease due to their similarities to humans in central nervous system mobility (Gallagher and Rapp 1997;Voytko and Tinkler 2004;Kulstad et al 2005;Zeng et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Aging and physical mobility in group-housed Old World monkeys

Shively

Willard

et al. 2011

AGE

Self Cite

View full text Add to dashboard Cite

While indices of physical mobility such as gait speed are significant predictors of future morbidity/ mortality in the elderly, mechanisms of these relationships are not understood. Relevant animal models of aging and physical mobility are needed to study these relationships. The goal of this study was to develop measures of physical mobility including activity levels and gait speed in Old World monkeys which vary with age in adults. Locomotor behaviors of 21 old (x0 20 yoa) and 24 young (x09 yoa) socially housed adult females of three species were recorded using focal sample and ad libitum behavior observation methods. Selfmotivated walking speed was 17% slower in older than younger adults. Likewise, young adults climbed more frequently than older adults. Leaping and jumping were more common, on average, in young adults, but this difference did not reach significance. Overall activity levels did not vary significantly by age, and there were no significant age by species interactions in any of these behaviors. Of all the behaviors evaluated, walking speed measured in a simple and inexpensive manner appeared most sensitive to age and has the added feature of being least affected by differences in housing characteristics. Thus, walking speed may be a useful indicator of decline in physical mobility in nonhuman primate models of aging.

show abstract

Social Stress, Visceral Obesity, and Coronary Artery Atherosclerosis in Female Primates

Cited by 67 publications

References 37 publications

Stressful life events and incident metabolic syndrome: the Hoorn study

Stressful life events and incident metabolic syndrome: the Hoorn study

Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome

Aging and physical mobility in group-housed Old World monkeys

Contact Info

Product

Resources

About