“…A meta-analysis of patient adherence to medical treatment found that greater structural, functional, and quality measures of social connection were associated with better adherence, with the strongest effect for social support. 62 Greater social support has also been strongly associated with favorable sleep outcomes, 63 , 64 whereas loneliness has been associated with increased sleep fragmentation, poorer sleep quality and consequent metabolic, neural, and hormonal dysregulation. 1 , 4 , 65 , 66 , 67 , 68 A study examining the association of greater loneliness with cardiovascular disease, diabetes, and migraine among 8,600 older adults found significant mediation effects attributable to behavioral variables such as poor sleep, physical inactivity, and daily smoking.…”