Social Support, Psychological Distress, and Natural Killer Cell Activity in Ovarian Cancer

Lutgendorf, Susan K.; Sood, Anil K.; Anderson, Barrie; McGinn, Stephanie; Maiseri, Heena; Dao, Minh; Sorosky, Joel I.; Geest, Koen De; Ritchie, Justine M.; Lubaroff, David M.

doi:10.1200/jco.2005.10.015

Cited by 256 publications

(186 citation statements)

References 52 publications

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“…The relationship between levels of distress and immune factors was assessed in three good studies [18,23,24]. Costanzo et al [18] found that a history of depression and increased depressed mood were associated with higher levels of interleukin-6 in ascitic fluid.…”

Section: Resultsmentioning

confidence: 99%

“…Lutgendorf et al [23] found that higher levels of helplessness were associated with higher levels of vascular endothelial growth factor, a pro-angiogenic factor, which is associated with poorer survival. Lutgendorf et al [24] found that increased levels of distress were associated with lower levels of natural killer cells in tumour-infiltrating lymphocytes. Thus, various indices of distress are correlated with biomarkers of important prognostic factors in ovarian cancer.…”

Section: Resultsmentioning

confidence: 99%

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Psychological distress and its correlates in ovarian cancer: a systematic review

2008

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Objective: Ovarian cancer is often diagnosed at an advanced stage, and consequently high levels of distress are often experienced. It is necessary to understand the factors associated with psychological distress in order to guide interventions to target those factors. The purpose of this systematic review was therefore to identify correlates of psychological distress in ovarian cancer.Methods: Included studies had to be quantitative and empirical, with standardized measures of psychological distress (anxiety or depression), and to present results for ovarian cancer patients specifically. Standard systematic search methods were used. Information about design, ovarian cancer sample size, disease stage, time since diagnosis, measures of distress used and findings was extracted from each study. The studies were quality assessed using experimenterdefined criteria as good, average and poor quality. Strength of the evidence (strong, some, inconclusive) was based on the quality and consistency of findings.Results: Eighteen studies meeting the inclusion criteria were identified. There was strong evidence for a relationship between younger age, being diagnosed with more advanced disease, more physical symptoms and shorter time since diagnosis with increased levels of anxiety and/ or depression. Additional factors (e.g. immune) tested in a few studies also emerged as correlates of distress.Conclusions: Demographic, disease and quality of life factors correlated with distress. However, too few studies assessed possible psychological and immunological correlates, which could be potentially modified and should be assessed in future studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Psychological distress and its correlates in ovarian cancer: a systematic review

2008

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“…We used a nonselective b-antagonist (propranolol), as human leukocytes and human tumor cells express both b-1 and b-2 adrenoceptors (50, 51), and as our previous study indicated that the blockade of both receptor systems was more effective than each alone in preventing stress-induced promotion of metastasis (52). Importantly, in the clinical setting of oncologic surgery, the drug regimen used in this study may be even more efficient if initiated a few days before surgery, because etodolac could reduce PGs release by primary tumors (14); propranolol could reduce anxiety (53) and antagonize the excess release of CAs owing to preoperative physiologic and psychologic stress responses (54,55). Together, preoperative use of these drugs can attenuate preoperative suppression of CMI in cancer patients awaiting surgery (10,56).…”

Section: Sectionmentioning

confidence: 99%

Improving Survival Rates in Two Models of Spontaneous Postoperative Metastasis in Mice by Combined Administration of a β-Adrenergic Antagonist and a Cyclooxygenase-2 Inhibitor

Glasner

Avraham

Rosenne

et al. 2010

The Journal of Immunology

218

177

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Clinical practice does not consider perioperative paracrine and neuroendocrine stress responses as risk factors for cancer recurrence, although recent animal studies provided supportive evidence. Suggested mechanisms include the effects of stress-hormones on tumor cells and on host physiology. In this study, in mice undergoing primary tumor excision, we tested the survival-enhancing potential of perioperative blockade of catecholamines and prostaglandins, and studied potential mediating mechanisms. C57BL/6J mice were inoculated intrafootpad with syngeneic B16F10.9-melanoma or Lewis lung carcinoma, and the paw was amputated when a developing tumor exceeded 100 μl. The clinically used β-adrenergic antagonist propranolol, and/or the cyclooxygenase-2 inhibitor etodolac, were administered once before amputation, and recurrence-free survival was monitored. In different studies, NK cytotoxicity, leukocytes' molecular functional markers, and vascular endothelial growth factor secretion by tumor cells were studied in the context of surgery and drug treatments. The findings indicated that the combination of propranolol and etodolac, but neither drug alone, significantly and markedly improved survival rates in both tumor models, and was as effective as established immunostimulatory agents (IL-12 and polyinosinic-polycytiylic acid). Surgery markedly reduced NK cytotoxicity and NK cell expression of Fas ligand and CD11a, reduced all circulating lymphocyte-subtype concentrations, and increased corticosterone levels. Propranolol and etodolac administration counteracted these perturbations. B16 and 3LL secreted vascular endothelial growth factor in vitro, but secretion was not affected by catecholamine agonists, prostaglandins, corticosterone, propranolol, or etodolac. Overall, propranolol and etodolac administration, which could be applied perioperatively in most cancer patients with minimal risk and low cost, has counteracted several immunologic and endocrinologic perturbations and improved recurrence-free survival rates in mice undergoing primary tumor excision.

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“…Social support was assessed by the Attachment subscale of the Social Provisions Scale (SPS-Attachment) (Cutrona and Russell 1987). Based on an a priori hypothesis derived from previous studies of biobehavioral risk factors in ovarian cancer (Costanzo, Lutgendorf et al 2005;Lutgendorf, Sood et al 2005), high psychosocial risk was defined by the presence of a CESD score ≥ 16 and SPS-Attachment score ≤ 15 (the median value). The Beck Depression Inventory (BDI) was also collected for comparison with other published studies, but the CESD served as the primary measure of depression.…”

Section: Depression Social Support and Background Characteristicsmentioning

confidence: 99%

Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

Lutgendorf

DeGeest

Sung³

et al. 2009

Brain, Behavior, and Immunity

Self Cite

155

157

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Motivated by previous indications that beta-adrenergic signaling can regulate tumor cell gene expression in model systems, we sought to determine whether similar dynamics occur in primary human ovarian cancer. DNA microarray analyses of 10 ovarian carcinomas identified 266 human transcripts that were differentially expressed in tumors from patients with elevated biobehavioral risk factors (high depressive symptoms and low social support) relative to grade-and stage-matched tumors from low-risk patients. Promoter-based bioinformatic analyses confirmed increased activity of several beta-adrenergically-linked transcription control pathways, including CREB/ATF, NF-κB/ Rel, STAT, and Ets family transcription factors. Consistent with increased beta-adrenergic signaling, high biobehavioral risk patients also showed increased intra-tumor concentrations of norepinephrine (but no difference in plasma norepinephrine). These data show that genome-wide transcriptional profiles are significantly altered in patients with high behavioral risk profiles, and they identify betaadrenergic signal transduction as a likely mediator of those differences.

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Social Support, Psychological Distress, and Natural Killer Cell Activity in Ovarian Cancer

Cited by 256 publications

References 52 publications

Psychological distress and its correlates in ovarian cancer: a systematic review

Psychological distress and its correlates in ovarian cancer: a systematic review

Improving Survival Rates in Two Models of Spontaneous Postoperative Metastasis in Mice by Combined Administration of a β-Adrenergic Antagonist and a Cyclooxygenase-2 Inhibitor

Depression, social support, and beta-adrenergic transcription control in human ovarian cancer

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