Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams

Manley, Brett J.; Böhm, Birgitta; Wassenaer-Leemhuis, Aleid G. van; D’Ilario, Judy; Cairnie, Janice; Dix, Joanne; Adams, Beth; Warriner, Erin M.; Kim, Mee-Hai Marie; Argus, Brenda; Callanan, Catherine; Duff, Julianne; McDonald, Marion; Hohn, Denise; Lacy, Maralyn; Haslam, Ross; Barnett, Christopher; Goodchild, Louise; Lontis, Rosslyn Marie; Fraser, Simon; Keng, Julie; Saunders, Kerryn; Opie, Gillian; Kelly, Elaine; Woods, Heather; Marchant, Emma; Turner, Anne‐Marie; Davis, Noni; Magrath, Emma; Williamson, A.C.; Bairam, Aïda; Bélanger, Sylvie; Fraser, Annie; Blayney, Marc; Lemyre, Brigitte; Frank, J. Howard; Synnes, Anne; Hubber-Richard, Philippa; Rogers, Marilyn; MacKay, Margot; Petrie-Thomas, Julianne; Butt, Arsalan; Wassenaer, Aleid van; Nuytemans, Debbie H. G. M.; Houtzager, Bregje A.; Sonderen, Loekie van; Regev, Rivka; Itzchack, Netter; Arnon, Shmuel; Chalaf, Adiba; O’Brien, Karel; Hamilton, Anne-Marie; Chan, May Lee; Sankaran, Koravangattu; Proctor, Pat; Golan, Agneta; Goldsch-Lerman, Esther; Reynolds, Graham; Dromgool, Barbara; Meskell, Sandra; Parr, V; Maher, Catherine; Broom, Margaret; Kecskés, Zsuzsoka; Ringland, Cathy; McMillan, Douglas; Spellen, Elizabeth; Sauve, Reginald S.; Christianson, Heather; Anseeuw-Deeks, Deborah; Creighton, Dianne; Heath, Jennifer; Alvaro, Ruben; Chiu, Aaron; Porter, Ceceile; Turner, Gloria E.; Granke, Naomi; Penner, Karen; Bow, Jane; Mulder, Antonius; Wassenberg, Renske; Hoeven, Markus van der; Clarke, Maxine C; Parfitt, J. B.; Parker, Kevin C. H.; Nwaesei, Chukwuma; Ryan, Heather; Saunders, Cory D.; Schulze, Andreas; Wermuth, Inga; Hilgendorff, Anne; Flemmer, Andreas W.; Herlenius, Eric; Legnevall, Lena; Lagercrantz, Hugo; Matthew, Derek; Amos, Wendy; Tulsiani, Suresh; Tan-Dy, Cherrie; Turner, Marilyn L.; Phelan, Constance; Shinwell, Eric S.; Levine, Michael H.; Juster-Reicher, Ada; Khairy, May; Grier, Patricia; Vachon, Julie; Perepolkin, Larissa; Sinha, Sunil K.; Walti, Hervé; Royer, Diane; Halliday, Henry L.; Millar, David; Mayes, Clifford; McCusker, Christopher; McLaughlin, Olivia M.; Fahnenstich, Hubert; Tillmann, Bettina; Weber, Peter; Wariyar, Unni; Embleton, Nicholas; Swamy, Ravi; Bucher, Hans Ulrich; Fauchère, Jean‐Claude; Dietz, V.; Harikumar, C; Fritz, Susan; Schmidt, Barbara; Anderson, Peter J.; Asztalos, Elizabeth; Barrington, Keith J.; Davis, Peter G; Dewey, Deborah; Doyle, Lex W.; Grunau, Ruth E.; Moddemann, Diane; Ohlsson, Arne; Solimano, Alfonso; Tin, Win; Gent, Michael; Fraser, William D.; Hey, Edmund; Perlman, Max; Thorpe, Kevin E.; Gray, Shari; Roberts, Robin S.; Chambers, C. T.; Costantini, Lorrie; Yacura, Wendy; McGean, Erin; Scapinello, Lori

doi:10.1016/j.jpeds.2014.12.016

Cited by 44 publications

(39 citation statements)

References 26 publications

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“…Concerns have also been raised regarding how well the Bayley-3 rd edition performed at 2yr predicts 4yr cognitive outcomes 80 . In addition, a recent study demonstrates that parental socioeconomic status has an important effect in cognitive gains over time 81 . In this study, infants born to parents with higher education and whose caregivers were employed had greater cognitive gains in neurodevelopmental assessments between 18 months and 5 years of age.…”

Section: Neurodevelopmental Outcomes Including Effects Of Short-termmentioning

confidence: 99%

Short- and Long-Term Outcomes for Extremely Preterm Infants

2016

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Prematurity is the leading cause of infant mortality worldwide. In developed countries, extremely preterm infants contribute disproportionately to both neonatal and infant mortality. Survival of this high-risk population has incrementally improved in recent years. Despite these improvements, approximately 1 in 4 extremely preterm infants dies during the birth hospitalization. Among those who survive, respiratory and other morbidities are common, although their effect on quality of life is variable. In addition, long-term neurodevelopmental impairment is a large concern for patients, clinicians and families. However, the interplay of multiple factors contribute to neurodevelopmental impairment, with measures that change over time and outcomes that can be difficult to define and predict. Understanding outcomes of extremely preterm infants can help better counsel families regarding antenatal and postnatal care and guide strategies to improve survival without morbidity. This review summarizes recent evidence to provide an overview into the short- and long-term outcomes for extremely preterm infants.

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Section: Neurodevelopmental Outcomes Including Effects Of Short-termmentioning

confidence: 99%

Short- and Long-Term Outcomes for Extremely Preterm Infants

2016

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“…In the current study, neither in-hospital nor post-discharge medical characteristics of the children were related to attrition, but sociodemographic factors were strongly related to study completion. Importantly, sociodemographic factors are also strongly related to both high-risk infants’ developmental outcomes as well as developmental trajectories [20-23]. Thus, attrition in studies such as PROP may be nonrandom, and attrition among children with differing sociodemographic backgrounds is likely to bias the results of longitudinal studies [24].…”

Section: Discussionmentioning

confidence: 99%

Patient, Family, and Center-Based Factors Associated with Attrition in Neonatal Clinical Research: A Prospective Study

et al. 2019

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Background: Attrition, or loss to follow-up, presents a significant threat to the integrity and validity of longitudinal clinical research. Little is known about predictors of attrition in neonatal clinical research, and no prior studies have examined how families’ experiences participating in research with their infants influences study compliance. Objective: To identify novel factors that were associated with attrition over 1 year of study follow-up among preterm infants enrolled in the multicenter Prematurity and Respiratory Outcomes Program (PROP) observational study. Methods: At discharge, research coordinators estimated the likelihood of attrition. The parents completed questionnaires about their experience with the study at discharge and at 1 year corrected age. The primary endpoint was completion of 4 PROP interviews during the first year. Logistic models were used to evaluate the associations between infant, family, and center-based characteristics and attrition. Results: Among 318 children, 283 (89%) met the primary endpoint. In bivariate analyses, lower maternal education, more people in the household, public insurance, and site were associated with attrition (p < 0.05). Parent survey responses, infant characteristics, and site characteristics were unrelated to attrition. Coordinators’ prediction of attrition was associated with completion of early study interviews; this effect waned over time. In multivariable analyses, lower maternal education and more people in the household were the factors most strongly associated with attrition. Conclusion: Future neonatal research should evaluate novel strategies to decrease the burden associated with study participation and reinforcement of study goals with families who have lower educational levels to facilitate participation and decrease attrition bias.

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“…The authors examined common risk factors with univariable meta‐regression revealing that variance in IQ effect size was associated with bronchopulmonary dysplasia (BPD), postnatal corticosteroids, GA, BW and brain injury, supporting reports on the significance of these risk factors . In contrast, necrotising enterocolitis (NEC), sepsis, small for gestational age (SGA), sex, race and maternal education explained little of the variance in the IQ effect size, which was surprising given these factors are consistently associated with cognitive outcome in very preterm cohort studies . We know that many biological, medical, social and environmental factors influence child development, and the results of Twilhaar et al are likely to partly reflect methodological differences between studies such as selection criteria (GA and BW criteria) and clinical definitions (especially BPD).…”

mentioning

confidence: 90%