Illicit drug abuse and drug-related crimes are still a growing problem worldwide. Understanding the increasing number of individuals arrested for drug charges, as well as their characteristics is necessary to predict and establish preventive and treatment programs. Methods: This cross-sectional study was conducted in Shahroud, Northeast of Iran from 2015-2018. Data were collected at the time of arrest from all homeless addicts and drug offenders arrested by the police and were sent to the rehabilitation camps or prisons (n=5486). Results: Drug-related charges were the largest category of arrest charges in Shahroud. The mean age of arrestees had significantly decreased each year. In total, 19.1% of the arrestees were referred to the rehabilitation camps (18.6% male and 40.3% female). The number of cases arrested for drug charges referred to the rehabilitation camps had significantly increased over time in both men and women. The number of arrestees showed an increase each year, whereas their mean age had decreased significantly. Discussion: Drug-related laws in Iran have been reformed, emphasizing the judicial supervision of arrest, treatment, and release processes. Treatment of arrestees with drug abuse provides opportunities for decreasing substance abuse and criminal behaviors and rearrests.