Societal Costs and Morbidity of Pertussis in Adolescents and Adults

Lee, Grace M.; Lett, Susan M.; Schauer, Stephanie L.; LeBaron, Charles W.; Murphy, Trudy V.; Rusinak, Donna; Lieu, Tracy A.

doi:10.1086/425006

Cited by 144 publications

(106 citation statements)

References 29 publications

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“…1 Physicians frequently do not recognize signs of pertussis in adolescents and adults, 3 yet the health and economic consequences of pertussis can be substantial. 4 In addition, addressing pertussis outbreaks using conventional approaches to interrupting disease transmission may be hindered by factors such as clustering of cases in hard-to-reach adult populations. 5 Furthermore, infants, especially those who have not yet received the routine three-dose primary series of childhood diphtheria-tetanus-pertussis vaccine, are particularly vulnerable to severe complications and death from pertussis, 6 and often become infected through exposure to adults with pertussis.…”

Section: Introductionmentioning

confidence: 99%

New Combined Tetanus-Diptheria-Acellular Pertussis Vaccines for Adults: Primary Care Physician Attitudes and Preferences

Davis

Kretsinger²,

Cowan

et al. 2007

Human Vaccines

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Availability of combined tetanus-diphtheria-acellular pertussis (Tdap) vaccines for adults offers a new pertussis prevention strategy for the US. Successful uptake of Tdap vaccine will depend partly on the attitudes and practices of primary care physicians, including their experience with Td boosters. We conducted a mail survey in August 2005 of a national random sample of 399 family physicians (FPs) and 399 general internists (IMs) to assess practices related to Td boosters, clinical experience with pertussis, and attitudes toward a potential Tdap vaccine recommendation for adults. The response rate was 49% (52% FPs, 46% IMs). Among 336 eligible respondents, half reported having clinical experience with pertussis. Most (81%) would recommend Tdap vaccine for their adult patients, and 73% support targeting adults likely to come in close contact with infants. Attitudes toward a potential Tdap vaccine recommendation differed by whether providers stock and administer Td boosters. We conclude that adult primary care providers in the US are likely to recommend Tdap vaccine to their adult patients, in concordance with recent national recommendations. Future research should assess the extent to which barriers impede adoption of Tdap vaccine recommendations.

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Section: Introductionmentioning

confidence: 99%

New Combined Tetanus-Diptheria-Acellular Pertussis Vaccines for Adults: Primary Care Physician Attitudes and Preferences

Davis

Kretsinger²,

Cowan

et al. 2007

Human Vaccines

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show abstract

“…[7][8][9] However, infections that are preventable by immunization continue to occur among substantial numbers of adolescents and adults, and these persons may transmit vaccine-preventable diseases to vulnerable populations. [10][11][12][13][14][15] Advances in immunology and biotechnology have led to development of new vaccines, many of which have been or will be targeted to adolescents (see the report by Fishbein et al 16 in this issue). During 2005 and 2006, a new tetravalent meningococcal conjugate vaccine (MCV4) and 2 tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (TdaP) vaccines were licensed and recommended by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices (ACIP) for use in adolescents.…”

mentioning

confidence: 99%

Adolescent Immunizations and Other Clinical Preventive Services: A Needle and a Hook?

et al. 2008

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Advances in technology have led to development of new vaccines for adolescents, but these vaccines will be added to a crowded schedule of recommended adolescent clinical preventive services. We reviewed adolescent clinical preventive health care guidelines and patterns of adolescent clinical preventive service delivery and assessed how new adolescent vaccines might affect health care visits and the delivery of other clinical preventive services. Our analysis suggests that new adolescent immunization recommendations are likely to improve adolescent health, both as a "needle" and a "hook." As a needle, the immunization will enhance an adolescent's health by preventing vaccine-preventable diseases during adolescence and adulthood. It also will likely be a hook to bring adolescents (and their parents) into the clinic for adolescent health care visits, during which other clinical preventive services can be provided. We also speculate that new adolescent immunization recommendations might increase the proportion and quality of other clinical preventive services delivered during health care visits. The factor most likely to diminish the positive influence of immunizations on delivery of other clinical preventive services is the additional visit time required for vaccine counseling and administration. Immunizations may "crowd out" delivery of other clinical preventive services during visits or reduce the quality of the clinical preventive service delivery. Complementary strategies to mitigate these effects might include prioritizing clinical preventive services with a strong evidence base for effectiveness, spreading clinical preventive services out over several visits, and withholding selected clinical preventive services during a visit if the prevention activity is effectively covered at the community level. Studies are needed to evaluate the effect of new immunizations on adolescent preventive health care visits, delivery of clinical preventive services, and health outcomes. Pediatricians have a unique opportunity to influence adolescents and their families by helping young people build a strong foundation of good health that will continue into their adult lives.American Academy of Pediatrics (AAP) 1 D ELIVERING PREVENTIVE services to US adolescents* is a public health priority. 2,3 Although most US adolescents are healthy, millions of adolescents initiate behaviors and lifestyles that can adversely affect their immediate and long-term health. 4 Potentially modifiable adolescent behaviors include failure to use seat belts, unsafe operation of motor vehicles, carrying weapons, using alcohol and other drugs, unprotected sex, inactivity, and overeating. These behaviors are directly linked to injuries and death, as well as to sexually transmitted infections (STIs), unintended *The definition of "adolescent" differs across studies and organizations; in this report, an adolescent is a person aged 11 to 18 years, unless otherwise specified.www.pediatrics.org/cgi

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“…1 Even for those not experiencing severe complications, prolonged periods with paroxysmal coughing bouts may result in multiple visits to a health provider and extended absences from school or work. [1][2][3] A combined diphtheria, tetanus, and whole pertussis vaccine was introduced into routine vaccination schedules for infants and young children in the late 1940s, and subsequently, a vaccine containing combined diphtheria, tetanus, and acellular pertussis (DTaP) was introduced in the late 1990s. 1 These vaccination strategies resulted in significant reductions in the annual incidence of pertussis and deaths due to pertussis in the United States, from approximately 200,000 cases per year in the prevaccine era to a low of 1,010 cases reported in 1976.…”

Section: ■■ Methods Model Structurementioning

confidence: 99%

Impact of Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Vaccine Use in Wound Management on Health Care Costs and Pertussis Cases

Talbird¹,

Graham²,

Mauskopf³

et al. 2015

JMCP

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BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) recommends the use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine for routine wound management in adolescents and adults who require a tetanus toxoid-containing vaccine who were vaccinated ≥5 years earlier with tetanus toxoid, reduced diphtheria toxoid (Td) vaccine, and who have not previously received Tdap.

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Societal Costs and Morbidity of Pertussis in Adolescents and Adults

Abstract: Pertussis causes significant morbidity in and costs for adolescents and adults, with time losses comprising the largest proportion of the cost. Societal costs should be considered when making decisions about potential vaccine use in the future.

Cited by 144 publications

References 29 publications

New Combined Tetanus-Diptheria-Acellular Pertussis Vaccines for Adults: Primary Care Physician Attitudes and Preferences

New Combined Tetanus-Diptheria-Acellular Pertussis Vaccines for Adults: Primary Care Physician Attitudes and Preferences

Adolescent Immunizations and Other Clinical Preventive Services: A Needle and a Hook?

Impact of Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Vaccine Use in Wound Management on Health Care Costs and Pertussis Cases

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