COVID-19 pandemic has once again raised the long-standing problem of trust in science and scientists. However, many approaches tend, on one hand, to analyze science as if it were an entirely autonomous entity – and thus to attribute the causes of the decline in trust to factors external to it; on the other hand, these approaches address the question of trust in a dichotomous manner, in terms of presence or absence of it. Rather than assuming a causal and linear direction that proceeds from one domain (‘the outside’ of science) to the other (science), we will draw on those perspectives that investigate the ways in which science interacts with other subsystems. This article aims to propose a more nuanced approach that can contribute to overcoming binary categorizations such as the one that distinguishes between processes internal to the scientific community and factors external to it; such categorizations are somehow implicit in the widespread use of concepts like ‘infodemic’, ‘disinformation’ or ‘pseudoscience’. To this end, two research directions were followed: first, two conflicts between experts that animated the public debate in Italy during the Sars-Cov-2 outbreak and forced scientists to interact following different social subsystems logics were analyzed. Second, in order to go beyond a binary view of trust and to further reveal attitudes toward science and scientists, we conducted a pilot study on a sample of online readers of two Italian newspapers. Overall, a more nuanced view of the issue of trust toward scientists emerges, which is expressed in five different attitudes toward them, and which takes into consideration both the way in which scientists communicate and the philosophy of science they implicitly express in media interactions.