Socio-Demographic and Adherence Factors Associated with Viral Load Suppression in HIV-Infected Adults Initiating Therapy in Northern Nigeria: A Randomized Controlled Trial of a Peer Support Intervention

Abstract

High levels of viral suppression and low prevalence of drug resistance mutations (DRMs) were seen in this cohort participating in an ART adherence study in Northern Nigeria. Self-reported good adherence and optimal Rx refill rates were reported as significant predictors of VL suppression. Our findings indicate that ART adherence will improve significantly regardless of whether HIV-infected adults received peer-education-based medication adherence interventions or standard of care services.

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature

“…These interventions included adherence support provided by lay health workers or volunteers, community- and facility-based adherence activities, home-based directly observed therapy (DOT) or adherence support by lay treatment supporters, and community-based social support. Two studies were conducted among both adults and adolescents [ 82 , 83 ]; the remaining 11 were conducted among adults [ 40 , 41 , 76 – 81 , 84 – 86 ].…”

“…Eight studies (three RCTs, two quasi-experimental studies, and one prospective and two retrospective cohort studies) tested or examined associations between adherence outcomes and community-based adherence support (CBAS) interventions [ 76 – 83 ]. Six studies were conducted among adults [ 76 – 81 ] and two included adults and adolescents [ 82 , 83 ]. CBAS interventions included adherence support through home visits by a community-based health worker or volunteer and included activities such as DOT, basic clinical assessments, referrals, pill counts, and home ART delivery.…”

“…Among the six overall fair-quality CBAS intervention studies conducted among adults [ 76 – 81 ], five had statistically significant results [ 76 – 80 ]. An RCT in China provided home visits by nurses and peer educators to non-adherent adults and found that greater proportions of patients achieved ≥90% adherence over the intervention period compared to the control (84% intervention, 53% control, p = 0.009) in adjusted analyses [ 76 ]; however, this study was limited by high loss to follow-up in the control group.…”

Retention and predictors of attrition among patients who started antiretroviral therapy in Zimbabwe’s national antiretroviral therapy programme between 2012 and 2015

“…Males were at risk of attrition in the prior evaluation but were not at risk in the current evaluation. Several studies have consistently showed males at high risk of attrition due to several reasons, including employment related constraints and poor health seeking behaviour leading to late presentation [13,15,38,39]. During the study period the country did not implement many specific interventions that targeted men.…”

The Role of Patient Characteristics and Group Support to Adherence Treatment in People with HIV/AIDS (PLWHA) in Cirebon City

“…Group support also has a positive effect on HIV patient compliance, this is supported by interactions between peer support group members, this is supported by previous research that 89.9% of peer support helps HIV patients in sharing and increasing knowledge and experience regarding the importance of taking drugs with sustained effect. The statement in question is that activities in peer support should not be stopped, because if stopped will have a role in the psychosocial of HIV patients, so that it can affect the ARV treatment process [21][22][23][24]. This statement can also be linked to the analysis of education in this study that education has no significant difference, because education itself has a short effect compared to interactions with peer support [25].…”