Socio-demographic and clinical profile of immuno-histochemically confirmed breast cancer in a resource limited country

Rahman, Ganiyu A.; Olatoke, Samuel; Agodirin, SO; Adeniji, K A

doi:10.11604/pamj.2014.17.182.2257

Cited by 7 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, 26 (86.3%) of the women presented with Stage III or IV disease, similar to other countries in the region [4,5]. In our study, a larger percentage of women were of younger age and had triple-negative and HER2positive disease, similar to other countries in the region [7,8].…”

Section: Discussionsupporting

confidence: 88%

“…Studies in African countries suggest low knowledge of breast cancer tending to impact on attitudes to uptake of screening and timely presentation when symptoms develop, resulting in late diagnosis [ 4 , 5 ] leading to poor survival [ 6 ]. Invasive ductal carcinoma is the most common presentation, with younger age at onset and increased incidence of HER2/neu positive and triple negative and basal-like breast cancers compared to Europe and North America [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating natural killer cells and their association with breast cancer and its clinico-pathological characteristics

N’da Marcelin,

Dasse,

Yeboah

et al. 2023

ecancer

View full text Add to dashboard Cite

Purpose Natural killer (NK) cells play a critical role in cancer immunosurveillance and hold promise as both therapies and prognostic markers in advanced disease. We explore factors that may influence NK cell concentration in the peripheral blood of women with breast cancer in Côte d’Ivoire compared to healthy controls and implications for future research in our context. Methods In this cross-sectional case-control study, blood samples were taken from 30 women diagnosed with breast cancer within 6 months of diagnosis and fifteen healthy women at University Teaching Hospital [Centre Hospitalier Universitaire (CHU)] Treichville in Abidjan, Côte d’Ivoire, from March to September 2018. The blood draw could take place at any time following diagnosis and through treatment. Demographic and clinical data were collected. NK cells were isolated, stained, analysed and counted using the flow cytometer at the Department of Immunology at CHU of Cocody. All p-values were two-sided. Results Mean age among 30 women with breast cancer was 49 years old compared to 45 years old for 15 controls ( p = 0.41). Among 30 women with breast cancer, 4 (13.3%) had Stage 2 disease, 14 (46.7 %) at Stage 3, and 12 (40%) at Stage 4. Fourteen (46.7%) had breast cancer that was hormone receptor-positive (HR+) HER2-negative, 10 (33.3%) had triple-negative cancer, three (10.0%) had HR+HER2+ disease, and three (10.0%) HR-HER2+ cancer. NK cell concentration was not associated with cancer diagnosis, age, cancer stage, subtype, or type of treatment patients received ( p > 0.05). Conclusion Although we did not find an association between NK cell concentration, cancer characteristics or treatment, our results be limited by the small sample size and timing of blood draw. Our next steps include a larger study to explore circulating NK cells prior to any treatment and NK cell infiltration within breast cancer tumour and correlating this with response to treatment and prognosis.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Circulating natural killer cells and their association with breast cancer and its clinico-pathological characteristics

N’da Marcelin,

Dasse,

Yeboah

et al. 2023

ecancer

View full text Add to dashboard Cite

show abstract

“…This still remains the standard surgical operation most frequently performed for operable breast cancer in most parts of the world. Different surgical rates have been reported across Nigeria and different parts of Africa [ 11 , 19 , 25 , 27 ]. The role of surgery for the loco-regional clearance cannot be over-emphasized as it represents the most popular option when there is limited infrastructure and access to chemotherapy and radiotherapy [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Socio-demographic, pattern of presentation and management outcome of breast cancer in a semi-urban tertiary health institution

Olaogun¹,

Omotayo²,

Ige³

et al. 2020

Pan Afr Med J

View full text Add to dashboard Cite

Introduction breast cancer is the most common malignancy in females worldwide and a major cause of cancer-related deaths in both developing and developed countries. The objective of this study was to determine the socio-demographics, pattern of presentation and management outcome of breast cancer patients. Methods clinical records of confirmed breast cancer patients between January 2011 and December 2015 at the Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria were reviewed. Results eighty two breast cancer patients were seen. Their ages ranged from 26-95 years (mean 48.9 ± 14.9 years, median 47.5 years). Eighty one (98.8%) were females and the majority (65.4%) were premenopausal. The peak age of incidence was in the 4 th decade. All patients presented with breast lump with mean duration of 9.49±6.1 months and size ranging from 2 to 16cm (mean 7.9±3.4 cm). Ten (12.2%) patients presented early, 61 (74.4%) were locally advanced while 11 (13.4%) had distant metastases. Fifty one (62.2%) patients had mastectomy. Only 38 (46.3%) patients completed six courses of chemotherapy. None had immunohistochemistry but they all routinely took tamoxifen. Only 4 (4.9%) had radiotherapy. Nineteen (23.2%) died within a year of presentation. The follow-up period ranged between 1 and 44 months (mean, 10.3 months). Thirty one (37.8%), 19 (23.2%) and 8 (9.8%) patients were seen during the first, second and third year of follow up respectively. Conclusion breast cancer mostly affects young premenopausal women presenting in advanced stage in our setting. The generally poor outcome is not unconnected with late presentation and inadequate diagnostic and treatment facilities.

show abstract

“…Women typically present with advanced cancers. 3 - 5 Pathology services are sparse and sometimes of low quality. 6 Access to mastectomy can be limited; chemotherapy is underused and often incomplete.…”

Section: Introductionmentioning

confidence: 99%

Quality of Breast Cancer Treatment at a Rural Cancer Center in Rwanda

O’Neil

Keating

Dusengimana

et al. 2018

JGO

View full text Add to dashboard Cite

PurposeAs breast cancer incidence and mortality rise in sub-Saharan Africa, it is critical to identify strategies for delivery of high-quality breast cancer care in settings with limited resources and few oncology specialists. We investigated the quality of treatments received by a cohort of patients with breast cancer at Butaro Cancer Center of Excellence (BCCOE), Rwanda’s first public cancer center.Patients and MethodsWe reviewed medical records of all female patients diagnosed with invasive breast cancer at BCCOE between July 2012 and December 2013. We evaluated the provision of chemotherapy, endocrine therapy, surgery, and chemotherapy dose densities. We also applied modified international quality metrics and estimated overall survival using interval-censored analysis.ResultsAmong 150 patients, 28 presented with early-stage, 64 with locally advanced, and 53 with metastatic disease. Among potentially curable patients (ie, those with early-stage or locally advanced disease), 74% received at least four cycles of chemotherapy and 63% received surgery. Among hormone receptor–positive patients, 83% received endocrine therapy within 1 year of diagnosis. Fifty-seven percent of potentially curable patients completed surgery and chemotherapy and initiated endocrine therapy if indicated within 1 year of biopsy. Radiotherapy was not available. At the end of follow-up, 62% of potentially curable patients were alive, 24% were dead, and 14% were lost to follow-up.ConclusionAppropriate delivery of chemotherapy and endocrine therapy for breast cancer is possible in rural sub-Saharan African even without oncologists based on site. Performing timely surgery and ensuring treatment completion were key challenges after the opening of BCCOE. Further investigation should examine persistent quality gaps and the relationship between treatment quality and survival.

show abstract

Socio-demographic and clinical profile of immuno-histochemically confirmed breast cancer in a resource limited country

Cited by 7 publications

References 9 publications

Circulating natural killer cells and their association with breast cancer and its clinico-pathological characteristics

Circulating natural killer cells and their association with breast cancer and its clinico-pathological characteristics

Socio-demographic, pattern of presentation and management outcome of breast cancer in a semi-urban tertiary health institution

Quality of Breast Cancer Treatment at a Rural Cancer Center in Rwanda

Contact Info

Product

Resources

About