Socio-Demographic Characteristics and Risk Factors Contributing Pulmonary Tuberculosis Infection and Recent Transmission

Abstract

Host factors, environmental factors, genetic diversity and distinct phylogeographic distribution of Mycobacterium tuberculosis (MTB) contribute to regional differences in drug resistance. Bangladesh remains among the top 20 high Multi drug resistant tuberculosis (MDR-TB) burden countries of the world. This cross sectional study was conducted to identify the socio demographic characteristics and the risk factors contributing Pulmonary tuberculosis (PTB) infection. These characteristics and risk factors were further investigated among the clustered isolates. Total 60 culture isolates consist of 40 RR and 20 rifampicin sensitive (RS) isolates were enrolled in this study. Laboratory works were done in National Tuberculosis Reference Laboratory

Xpert MTB/RIF assay among the extra-pulmonary and non-sputum respiratory samples: One year experience at National Tuberculosis Reference Laboratory, Bangladesh

“…We found 66.2% MTB positive cases from urban (including metropolitan) area compared to 33.8% in rural area. This population distribution pattern was also observed by 23 . We also found 38% of EPTB cases were from middle income families (2 nd quartile of wealth index) but 45% of RR-TB cases were from high income group (3 rd quartile).…”

“…This is similar to a study conducted in India 30. But previous studies of Bangladesh among the Rifampicin resistant PTB patients showed male predominance 23,29,31 . However, the very few numbers of patients with Rifampin resistance in this study may limit the comparison between males and females.…”

“…Age group and wealth index related data for Rifampicin resistant EPTB is scarce. Studies in Bangladesh conducted among the Rifampicin resistant/MDR PTB also found younger age group to be predominant as well 23,29 . Our study revealed female predominance among the Rifampicin resistant EPTB.…”