Socio-demographic Profile and Drug Sensitivity Pattern of Suspected Drug Resistant Tuberculosis among Patients in Regional Tuberculosis Reference Laboratory (R.T.R.L) of a Tertiary Hospital

Khatun, Ummay Fatema; Amin, Robed; Islam, M Z; Rob, Abdur; Rahim, Abdur

doi:10.3329/jom.v18i2.33680

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…18 75/77 of the patients in our study had a previous history of anti-tuberculous therapy. This is almost similar to a study in Bangladesh on sociodemographic profile and drug sensitivity pattern of DR TB, 19 where all the MDR TB patients had previous history of ATT. MDR TB and mono resistant TB were the most common resistance pattern in patients with previous ATT.…”

Section: Discussionsupporting

confidence: 88%

Clinical and socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant DR TB patients registered for treatment at a tertiary care centre in South India

Kallarakal

Cency²

2022

PJMS

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Drug resistant tuberculosis is a major threat to TB elimination activities. In our study, we address the clinical, socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant TB patients.A record based cross sectional study was conducted in 77 Drug Resistant TB cases registered for standardized treatment at a tertiary care centre in South India from January 2012 to December 2019. The clinical, socio-demographic, radiological characteristics, drug sensitivity pattern and treatment outcome of these patients were recorded. 51 were males and 26 were females. 31 (40.3%) were diabetic, 30 (39%) were tobacco users, 12 (15.6%) were health care workers, 40 (52%) had low BMI and 4 (5.2%) were HIV-TB. 66 (85.7%) showed resistance to isoniazid, 62 (80.5%) to rifampicin, 8 (10.4%) to ethambutol, 9 (11.7%) to Fluoroquinolones, 2 (2.6%) to Second Line Injectables and 6 (7.8%) to Streptomycin. Treatment outcomes were as follows: cured 41 (61%), treatment completed 2 (2.6%), failure 2 (2.6%), lost to follow up 9 (11.7%), regimen changed 3 (3.9%), died 11 (14.3%), not evaluated 2 (2.6%) and treatment stopped due to adverse drug reactions 1 (1.3%). Unfavourable treatment outcomes were associated with low BMI, previous ATT and fluoroquinolone resistance.More than half of the patients had favourable treatment outcomes. Low BMI, previous ATT and fluoroquinolone resistance were factors associated with poor outcomes.

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Section: Discussionsupporting

confidence: 88%

Clinical and socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant DR TB patients registered for treatment at a tertiary care centre in South India

Kallarakal

Cency²

2022

PJMS

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“…Such patients pose a severe threat to transmission in the community. Therefore, molecular characterization and patient-specific resistance profiling is important [ 120 ].…”

Section: Impact Of Treatment Optionsmentioning

confidence: 99%

A Saudi Arabian Public Health Perspective of Tuberculosis

Saati

Khurram

Faidah

et al. 2021

IJERPH

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Tuberculosis is a global health challenge due to its spreading potential. The Kingdom of Saudi Arabia (KSA) faces a challenge in the spread of tuberculosis from migrant workers, but the foremost threat is the huge number of pilgrims who travel to visit sacred sites of the Islamic world located in the holy cities of Makkah and Al Madina. Pilgrims visit throughout the year but especially in the months of Ramadan and Zul-Hijah. The rise of resistance in Mycobacterium tuberculosis is an established global phenomenon that makes such large congregations likely hotspots in the dissemination and spread of disease at a global level. Although very stringent and effective measures exist, the threat remains due to the ever-changing dynamics of this highly pathogenic disease. This overview primarily highlights the current public health challenges posed by this disease to the Saudi health system, which needs to be highlighted not only to the concerned authorities of KSA, but also to the concerned global quarters since the pilgrims and migrants come from all parts of the world with a majority coming from high tuberculosis-burdened countries.

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“…Although there are effective treatment regimens consisting of first-line (i.e., streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide) and second-line drugs (i.e., fluoroquinolones, amikacin, kanamycin, capreomycin, ethionamide, prothionamide, cycloserine, and para-aminosalicylic acid), successful treatment outcomes are often challenged by the development of drug-resistant (DR) strains, the adverse effects of drugs, and lengthy treatment procedures [ 2 , 3 , 4 , 5 ]. The burden of multi-DR-TB (MDR-TB; resistance to both isoniazid and rifampicin) and extensively-DR-TB (XDR-TB; MDR-TB along with resistance to fluoroquinolones and one of the second-line injectable drugs) are expected to increase in countries with high-burden TB.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Antibiotic-Resistant Pulmonary Tuberculosis in Bangladesh: A Systematic Review and Meta-Analysis

et al. 2020

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Resistance to anti-tuberculosis (anti-TB) antibiotics is a major public health concern for many high-TB burden countries in Asia, including Bangladesh. Therefore, to represent the overall drug-resistance pattern against TB in Bangladesh, a systematic review and meta-analysis was conducted. Databases such as PubMed, Scopus, and Google Scholar were searched to identify studies related to antibiotic-resistant TB. A total of 24 studies covering 13,336 patients with TB were secured and included. The random-effects model was used to calculate the summary estimates. The pooled prevalence of any, mono, multi, poly, and extensive anti-TB antibiotic-resistances were 45.3% [95% CI: 33.5–57.1], 14.3% [95% CI: 11.4–17.2], 22.2% [95% CI: 18.8–25.7], 7.7% [95% CI: 5.6–9.7], and 0.3% [95% CI: 0.0–1.0], respectively. Among any first and second-line anti-TB drugs, isoniazid (35.0%) and cycloserine (44.6%) resistances were the highest, followed by ethambutol (16.2%) and gatifloxacin (0.2%). Any, multi, and poly drug-resistances were higher in retreatment cases compared to the newly diagnosed cases, although mono drug-resistance tended to be higher in newly diagnosed cases (15.7%) than that in retreatment cases (12.5%). The majority (82.6%) of the included studies were of high quality, with most not exhibiting publication bias. Sensitivity analyses confirmed that all outcomes are robust and reliable. It is concluded that resistance to anti-TB drugs in Bangladesh is rampant and fast growing. Therefore, the implementation of a nationwide surveillance system to detect suspected and drug-resistant TB cases, as well as to ensure a more encompassing treatment management by national TB control program, is highly recommended.

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Socio-demographic Profile and Drug Sensitivity Pattern of Suspected Drug Resistant Tuberculosis among Patients in Regional Tuberculosis Reference Laboratory (R.T.R.L) of a Tertiary Hospital

Cited by 5 publications

References 12 publications

Clinical and socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant DR TB patients registered for treatment at a tertiary care centre in South India

Clinical and socio-demographic profile, drug sensitivity pattern and treatment outcome of drug resistant DR TB patients registered for treatment at a tertiary care centre in South India

A Saudi Arabian Public Health Perspective of Tuberculosis

Prevalence of Antibiotic-Resistant Pulmonary Tuberculosis in Bangladesh: A Systematic Review and Meta-Analysis

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