Nigeria has rich agricultural resources endowment and an avalanche of laudable agricultural policies that could turn her into an industrialized economy and reduce the incidence ofhunger and poverty. This study highlighted that agripreneurship programme is vital to develop entrepreneurs and leaders to improve agribusiness in Nigeria. This study defined the concept of agripreneurship and its role in enhancing climate resilience in Nigeria. It recommended that climate resilience and sustainable economic growth can be achieved if we run agriculture as a business to enhance climate resilience and encourage private-sector led engagements as the main objective driver. It further enumerated the numerous benefits of agripreneurship as it helps to build resources by wealth creation along the value chain through production, value addition, and export of processed or unprocessed goods among others.It concluded by the call for more indepth research on agripreneurship and its role in enhancing climate resilience in Nigeria.