Socio-epidemiological Aspects of Respiratory Allergic Diseases in Southern Africa

Taborda-Barata, Luís; Potter, Paul

doi:10.1097/wox.0b013e318242d6b4

Cited by 16 publications

(15 citation statements)

References 45 publications

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“…Mite allergens were slightly more prevalent in rural areas, but differences were not as pronounced as in a Polish study revealing significantly higher exposure in rural regions [21]. We, however, found significantly reduced mite allergen concentrations in alpine regions, which also translated into reduced IgE levels.…”

Section: Discussioncontrasting

confidence: 77%

“…Exposure to indoor allergens has been linked to IgE sensitization and development of allergic symptoms in a number of studies. However, there are controversial findings regarding the kind of correlation, ranging from a protective effect upon high exposure to certain allergens [14–16] to a negatively influencing effect [17–19], whereas other studies found no effect at all [20, 21]. Also, exposure itself is influenced by different factors such as pet ownership, infrastructural characteristics or altitude.…”

Section: Introductionmentioning

confidence: 99%

“…Also, exposure itself is influenced by different factors such as pet ownership, infrastructural characteristics or altitude. These influences are widely discussed in the literature and strong differences in exposure between groups [6, 21–23] as well as no effects [24] from specific influencing factors are found. In order to assess allergen exposure, it is well established to measure allergen concentrations in house dust samples using antibody-based detection systems [3].…”

Section: Introductionmentioning

confidence: 99%

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Exposure to Indoor Allergens in Different Residential Settings and Its Influence on IgE Sensitization in a Geographically Confined Austrian Cohort

et al. 2017

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BackgroundExposure to indoor allergens is crucial for IgE sensitization and development of allergic symptoms. Residential settings influence the allergen amount in house dust and hence allergic sensitization. Within this study, we investigated allergen exposure and molecule-based IgE levels in a geographically confined region and evaluated the impact of housing, pets and cleaning.Methods501 adolescents from Salzburg, Austria participated in this cross-sectional study. House dust samples were examined regarding major mite, cat, dog, and mold allergens using a multiplex assay. Serum samples of participants were analyzed for specific IgE to Der p 1, Der p 2, Fel d 1, Can f 1 and Alt a 1 using the multiplex array ImmunoCAP ISAC. Information on allergies, living areas, dwelling form (house, flat, farm), pets, and household cleanliness were obtained by a questionnaire.ResultsIn investigated house dust samples, the concentration of cat allergen was highest while the prevalence of mold allergens was very low. Participants showed IgE sensitization to Der p 1 (13.2%), Der p 2 (18.2%), Fel d 1 (14.4%), Can f 1 (2.4%) and Alt a 1 (2.0%). In alpine regions, lower mite allergen concentrations were detected which correlated with reduced IgE levels. A trend for increased sensitization prevalence from rural to alpine to urban regions was noted. Living on farms resulted in lower sensitization prevalence to mite and cat allergens, even though exposure to mites was significantly elevated. The presence of cats was associated with a lower sensitization rate and IgE levels to cat and mite allergens, and less frequent allergic diseases. Cleaning did not impact allergen concentrations, while IgE reactivity to mites and allergic diseases were more pronounced when living in cleaner homes.ConclusionAllergen exposure to indoor allergens was influenced by setting of homes. Living in a farm environment and having a cat at home showed a protective effect for IgE sensitization and allergies. This cross-sectional study in combination with hereditary and lifestyle factors enables development of risk schemes for a more efficient management and potential prevention of allergic diseases.

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Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exposure to Indoor Allergens in Different Residential Settings and Its Influence on IgE Sensitization in a Geographically Confined Austrian Cohort

et al. 2017

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“…22 There is a strong evidence that an imbalance between the reducing and oxidizing systems favoring a more oxidative state is present in the airway inflammation and a deficiency in the amount of antioxidants exists in the asthmatic airway. 23 Superoxide dismutases (SODs) are the major antioxidant defense systems against O 2 radical. 24 Vulnerability of CuZnSOD influenced by redox likely amplifies injury and inflammation during acute asthma attacks when reactive oxygen species are explosively generated.…”

Section: Researchmentioning

confidence: 99%

Role of Apo E and superoxide dismutase in patients with obstructive lung diseases

Almzaiel

Al-Ameri

Tariq

2017

J. contemp. med. sci.

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Objective Obstructive lung diseases (OLD) are chronic inflammatory disorders of the respiratory tract including asthma and chronic obstructive pulmonary disease (COPD). Apo lipoprotein E (Apo E), is a multifunctional protein as it intervenes the binding of lipoproteins or lipid complexes to specific cell-surface receptors. Experimental studies referred to the function of Apo E as an endogenous negative regulator of airway hyper responsiveness and goblet cell hyperplasia. The protective role of Apo E pathways primarily in respiratory disease was explained in human studies and research utilizing experimental murine model systems. Literature data reveal a strong association between redox status, including the enzyme superoxide dismutase (SOD) with both the development a severity of OLD. This study aims to investigate the relation between SOD antioxidant enzyme activity in addition to investigating the level of Apo E and the development of obstructive lung diseases (OLD). Methods Patients with OLD (n = 40) and 40 age-matched healthy controls were enrolled in this study. Serum samples were collected to test the role of Apo E and to test the effect of antioxidant enzyme SOD, and their influence on OLD, all measured by ELISA.Result The results showed a significant decrease in the level of serum SOD activity in patients with OLD when compared with control group (P < 0.05). However, the levels of Apo E did not show a significant difference between the two groups. Conclusion Decreased level of antioxidant SOD suggests the presence of an oxidative stress in asthmatic airways favoring a more oxidative state is present in the airway inflammation. The level of Apo E was non significantly increased in serum of patient, this suggests that protein level of Apo E does not change but may be Apo E gene expression is altered.

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“…Plant allergens such as grass and pollen are some of the agents of seasonal allergic rhinitis (6). Further, several examples of the agents of perennial allergic rhinitis include dust, active or passive smoking, indoor and outdoor fumes, microbes and parasites, animal proteins, dust mites, and roach (6,7).…”

Section: Introductionmentioning

confidence: 99%

Study of respiratory allergens and associated factors in patients with allergic rhinitis referring to Imam Ali clinic in Shahrekord

Zamani

Alipour

Ahmadi

et al. 2019

J Shahrekord Univ Med Sci

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Background and aims: Respiratory allergens cause several problems for people with allergic rhinitis and are considered as a global challenge. This disease is an IgE-mediated nasal inflammatory disease that is triggered by the contact of the allergen. Therefore, this study was conducted to investigate respiratory allergens and associated factors in patients with allergic rhinitis who referred to a clinic in Shahrekord located in the southwest of Iran. Methods: In this cross-sectional study, 200 patients including 100 males and 100 females were enrolled using a convenience sampling technique. Diagnoses were made according to clinical symptoms and observation. In addition, the skin prick tests were used to detect the allergens. Finally, data were recorded and then analyzed by Stata. Results: Based on the results, 73.5%, 70.5%, 46%, and 43% of the patients were allergic to the following allergens including Dermatophagoid pteronyssinus, Dermatophagoides parinae, tree, and grass, respectively. Further, the mean height in the group with a positive and negative test for the inhaled allergens equaled 144.92±29.72 and 131.65±30.93, respectively, with a statistically significant difference (P<0.05). However, the mean weight, age, and the time at the onset of the disease were not significantly different between the two groups (P>0.05). Furthermore, the negative or positive reaction to the allergens failed to significantly differ with respect to gender, marital status, occupation, the county of residence, the area of residence, family size, and a family history of the disease (P>0.05). Conclusion: Allergic rhinitis is regarded as a common disorder among teenagers and young adults in this setting. Allergy to one or more respiratory allergens was found to be highly prevalent in patients with allergic rhinitis and the highest rate of allergy was observed to the mites, followed by tree and grass.

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Socio-epidemiological Aspects of Respiratory Allergic Diseases in Southern Africa

Cited by 16 publications

References 45 publications

Exposure to Indoor Allergens in Different Residential Settings and Its Influence on IgE Sensitization in a Geographically Confined Austrian Cohort

Exposure to Indoor Allergens in Different Residential Settings and Its Influence on IgE Sensitization in a Geographically Confined Austrian Cohort

Role of Apo E and superoxide dismutase in patients with obstructive lung diseases

Study of respiratory allergens and associated factors in patients with allergic rhinitis referring to Imam Ali clinic in Shahrekord

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