Socio-psychological stress-induced antinociception in diabetic mice

Abstract

These results indicate that emotional stress can readily induce antinociception in diabetic mice. Furthermore, this enhanced emotional stress-induced antinociception might be attributable to an increase in the production and/or release of endogenous ligands for benzodiazepine receptors, such as diazepam binding inhibitor, which act as inverse benzodiazepine receptor agonists.

Modification of the Effects of Benzodiazepines on the Exploratory Behaviors of Mice on a Hole-Board by Diabetes

“…Furthermore, socio-psychological stress-induced antinociception in diabetic mice was significantly reduced by treatment with diazepam (24). We also demonstrated that treatment with flumazenil significantly antagonized the socio-psychological stress-induced antinociception in diabetic mice (24). On the other hand, >-CCM significantly and dose-dependently enhanced the socio-psychological stress-induced antinociception in non-diabetic, but not in diabetic mice (24).…”

“…We also demonstrated that treatment with flumazenil significantly antagonized the socio-psychological stress-induced antinociception in diabetic mice (24). On the other hand, >-CCM significantly and dose-dependently enhanced the socio-psychological stress-induced antinociception in non-diabetic, but not in diabetic mice (24). Based on these results, we suggested that some endogenous substance(s) that act(s) as an inverse benzodiazepine receptor agonist may also be involved in the enhancement of socio-psychological stress-induced antinociception in diabetic mice (24).…”

“…On the other hand, >-CCM significantly and dose-dependently enhanced the socio-psychological stress-induced antinociception in non-diabetic, but not in diabetic mice (24). Based on these results, we suggested that some endogenous substance(s) that act(s) as an inverse benzodiazepine receptor agonist may also be involved in the enhancement of socio-psychological stress-induced antinociception in diabetic mice (24). A polypeptide with high affinity for benzodiazepine receptors was originally isolated from brain tissue of rodents and humans and called diazepam binding inhibitor (25).…”

“…We recently demonstrated that socio-psychological stress produced marked antinociception in diabetic mice, but not in non-diabetic mice (24). Furthermore, socio-psychological stress-induced antinociception in diabetic mice was significantly reduced by treatment with diazepam (24). We also demonstrated that treatment with flumazenil significantly antagonized the socio-psychological stress-induced antinociception in diabetic mice (24).…”

“…These results suggested that acute restraint stress may produce anxiety, and that the decrease in head-dipping behavior reflects this emotional state. We recently demonstrated that socio-psychological stress produced marked antinociception in diabetic mice, but not in non-diabetic mice (24). Furthermore, socio-psychological stress-induced antinociception in diabetic mice was significantly reduced by treatment with diazepam (24).…”