The Southeast Asian region faces security complexities that need to be taken into account, including border disputes, struggles over natural resources, the threat of drugs and terrorism, China's presence in the region, as well as security dilemmas and arms races. Although the current security situation is relatively peaceful with no significant conflict, the potential threat of war in the future cannot be ignored. This research aims to analyze the Regional Security Complex (RSC) framework in the security complexity of the Southeast Asia region. ASEAN countries are quite capable of maintaining regional security stability within the framework of friendship (Enmity). RSC theory is used to analyze the ASEAN cooperation framework in dealing with regional security complexity. A qualitative approach using literature study was used in this research. The findings of this research show that ASEAN countries have agreed to strengthen a friendship-based cooperation framework to continue to maintain the security stability of the Southeast Asian region.