Socio-sexual olfactory preference in female mice: Attractiveness of synthetic chemosignals

Jemioło, Bożena; Xie, Tian-Min; Novotný, Miloš V.

doi:10.1016/0031-9384(91)90570-e

Cited by 106 publications

(73 citation statements)

References 16 publications

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“…They showed that adding a mixture of brevicomin and thiazoline to the urine of castrated males at concentrations simulating the amount of these volatiles in normal male urine, made this urine as attractive as urine of gonadally intact males to virgin females. Farnesenes induce preferential chemoinvestigation by virgin female only if they are spiked at very high (supraphysiological) concentrations (250/500 ppm) in bladder urine or water (Jemiolo et al, 1991). By contrast, sexually experienced females recognize and prefer samples with lower concentrations of farnesenes (10 ppm, twice the level in voided urine), thus suggesting that farnesenes are odorants that become attractive by their association with sex or other innately attractive chemosignals.…”

Section: A Volatile Male Sexual Pheromones: Chemical Species and Thementioning

confidence: 99%

From sexual attraction to maternal aggression: When pheromones change their behavioural significance

Martín‐Sánchez

McLean

Beynon

et al. 2015

Hormones and Behavior

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From sexual attraction to maternal aggression: When pheromones change their behavioural significance, Hormones and Behavior (2014), doi: 10.1016/j.yhbeh.2014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT2 AbstractThis paper reviews the role of chemosignals in the socio-sexual interactions of female mice, and reports two experiments testing the role of pup-derived chemosignals and the male sexual pheromone darcin in inducing and promoting maternal aggression. Female mice are attracted to urine-borne male pheromones. Volatile and non-volatile urine fractions have been proposed to contain olfactory and vomeronasal pheromones. In particular, the male-specific major urinary protein (MUP) MUP20, darcin, has been shown to be rewarding and attractive to females. Non-urinary male chemosignals, such as the lacrimal protein ESP1, promote lordosis in female mice, but its attractive properties are still to be tested. There is evidence indicating that ESP1 and MUPs are detected by vomeronasal type 2 receptors (V2R).When a female mouse becomes pregnant, she undergoes dramatic changes in her physiology and behaviour. She builds a nest for her pups and takes care of them. Dams also defend the nest against conspecific intruders, attacking especially gonadally intact males. Maternal behaviour is dependent on a functional olfactory system, thus suggesting a role of chemosignals in the development of maternal behaviour. Our first experiment demonstrates, however, that pup chemosignals are not sufficient to induce maternal aggression in virgin females. In addition, it is known that vomeronasal stimuli are needed for maternal aggression.Since MUPs (and other molecules) are able to promote intermale aggression, in our second experiment we test if the attractive MUP darcin also promotes attacks on castrated male intruders by lactating dams. Our findings demonstrate that the same chemosignal, darcin, promotes attraction or aggression according to female reproductive state.

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Section: A Volatile Male Sexual Pheromones: Chemical Species and Thementioning

confidence: 99%

From sexual attraction to maternal aggression: When pheromones change their behavioural significance

Martín‐Sánchez

McLean

Beynon

et al. 2015

Hormones and Behavior

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“…The chemical composition of urine can be very complex. In several mammalian species (Burger, 2005;Jemiolo, Xie, & Novotny, 1991), including the aye-aye, Daubentonia madagascariensis (delBarcoTrillo, Harelimana, Goodwin, & Drea, 2013), compounds can be added to urine from secretory structures along the urogenital tract. The addition of compounds suggests that the chemical composition of urine is not completely tied to the physiological process of excretion, and that the chemical profiles of different species can thus evolve in response to the communication requirements in each species Burger, 2005;Jemiolo et al, 1991;Weinhold & Ingersoll, 1988).…”

Section: Chemical Signals In Strepsirrhine Primatesmentioning

confidence: 99%

Socioecological and phylogenetic patterns in the chemical signals of strepsirrhine primates

delBarco‐Trillo

Drea

2014

Animal Behaviour

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“…An important aspect in reproduction as a part of murine behaviour is at least to some extent influenced by pheromone-triggered scent communication [7][8][9][10][11][12][13][14][15][16]. The volatile pheromones are hydrophobic ligands that are bound, transported and released by major urinary proteins (Mups) [17].…”

Section: Introductionmentioning

confidence: 99%

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

et al. 2013

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Major urinary proteins (Mups) are important for rodent scent communication and sexual behaviour. Recent evidence suggests that Mup1 may be regulated by fasting and re-feeding (RF). However, other Mup isoforms are poorly investigated, and data on the impact of long-term dietary restriction (DR) and ad libitum RF on Mup expression are missing. We investigated the effects of long-term 25 per cent DR and subsequent RF on Mup expression in male C57BL6 mice. DR significantly decreased Mup gene expression, hepatic and urinary protein levels compared with ad libitum (AL) fed control mice, with the greatest downregulation found for Mup5 expression. The decline in Mup expression was inverted by six months of RF. Because of inhibitory glucocorticoid response elements in the genomic sequence of the Mup5 gene, the observed inverse correlation of nuclear glucocorticoid receptor levels with Mup expression in response to DR and subsequent RF is a possible regulatory mechanism. Additionally, gene-expression-inhibiting histone deacetylation (H3K9) occurred in the region of the Mup5 gene in response to DR. We assume that Mup may act as a molecular switch linking nutritional status to sexual behaviour of mice, and thereby regulating male fertility and reproduction in response to food supply.

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Socio-sexual olfactory preference in female mice: Attractiveness of synthetic chemosignals

Cited by 106 publications

References 16 publications

From sexual attraction to maternal aggression: When pheromones change their behavioural significance

From sexual attraction to maternal aggression: When pheromones change their behavioural significance

Socioecological and phylogenetic patterns in the chemical signals of strepsirrhine primates

Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice

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