The article deals with the formation of therapeutic scientific directions and the further development of scientific schools in the Kuban Region in the first half of the 20th century. Historiographic, biographical, problem-chronological, descriptive, and comparative methods are applied within the framework of social and cultural, and axiological approaches. The contribution of professors N. N. Nizhibitsky, K. M. Rutkevich, E. M. Zhadkevich, P. I. Budarina, V. L. Einis, K. A. Patsevich, and others is considered in the implementation of scientific research on a wide range of nosologies related to the clinical course of internal diseases that were widespread among the population at that time. It is revealed that the first half of the 20th century in the Kuban Region was a period of formation of specific areas of research activities in internal diseases. These areas were the forerunners of the building and development of scientific therapeutic schools of the Kuban, as well as the allocation of other independent scientific areas in the framework of introducing new medical specialties.