Sociodemographic and clinical characteristics of diet adherence and relationship with diet quality in an international cohort of people with multiple sclerosis

Simpson‐Yap, Steve; Nag, Nupur; Jakaria, M; Jelinek, George A; Neate, Sandra L

doi:10.1016/j.msard.2021.103307

Cited by 9 publications

(19 citation statements)

References 34 publications

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“…On each visit, participants will be asked about the adherence to specific diets and use of dietary supplements. For this, we apply a researcher-devised questionnaire from the Melbourne HOLISM cohort that is adapted to the German population [ 34 ]. Further, we implemented a questionnaire from the same research group related to type, frequency, duration and perceived effects of stress-reducing behaviors.…”

Section: Methodsmentioning

confidence: 99%

Berlin Registry of Neuroimmunological entities (BERLimmun): protocol of a prospective observational study

et al. 2022

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Background Large-scale disease overarching longitudinal data are rare in the field of neuroimmunology. However, such data could aid early disease stratification, understanding disease etiology and ultimately improve treatment decisions. The Berlin Registry of Neuroimmunological Entities (BERLimmun) is a longitudinal prospective observational study, which aims to identify diagnostic, disease activity and prognostic markers and to elucidate the underlying pathobiology of neuroimmunological diseases. Methods BERLimmun is a single-center prospective observational study of planned 650 patients with neuroimmunological disease entity (e.g. but not confined to: multiple sclerosis, isolated syndromes, neuromyelitis optica spectrum disorders) and 85 healthy participants with 15 years of follow-up. The protocol comprises annual in-person visits with multimodal standardized assessments of medical history, rater-based disability staging, patient-report of lifestyle, diet, general health and disease specific symptoms, tests of motor, cognitive and visual functions, structural imaging of the neuroaxis and retina and extensive sampling of biological specimen. Discussion The BERLimmun database allows to investigate multiple key aspects of neuroimmunological diseases, such as immunological differences between diagnoses or compared to healthy participants, interrelations between findings of functional impairment and structural change, trajectories of change for different biomarkers over time and, importantly, to study determinants of the long-term disease course. BERLimmun opens an opportunity to a better understanding and distinction of neuroimmunological diseases.

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Section: Methodsmentioning

confidence: 99%

Berlin Registry of Neuroimmunological entities (BERLimmun): protocol of a prospective observational study

et al. 2022

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“…Higher DSQ scores were seen in pwMS who followed Swank and Wahls diets (1). PwMS who adhered to the OMS-diet were 3.5 times more likely to have a high-quality diet indicated by DHQ scores above the median (11).…”

Section: Introductionmentioning

confidence: 93%

“…Some studies have shown adherence to MS-diet is associated with improved health outcomes in pwMS (8,9). For example, the OMS diet, a plant-based whole food (food that has been processed or refined as little as possible), low-saturated fat diet with seafood (10), has been cross-sectionally associated with lower fatigue, depression, and disability (11). Adherence to the OMS diet, as part of a multimodal lifestyle program, was prospectively associated with improved quality of life (QoL), and reduced fatigue and depression among 274 pwMS (12).…”

Section: Introductionmentioning

confidence: 99%

“…Diet quality has been assessed using different measurements such as food diaries, food frequency questionnaire (22), dietary screener questionnaire (DSQ) (23), and the diet habits questionnaire (DHQ). Cross-sectionally, studies have reported associations between high-quality diet with lower depression, pain, fatigue, disability and higher QoL (11,23,24). Prospectively, high-quality diet was associated with lower disability at 2.5-year follow-up (25) and lower depression at 10-years (26).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, ongoing adherence to diet may be challenging for some due to individual barriers of health, finance, lack of support, and personal motivation (28,29). Furthering our previous study showing that adherence to OMS-and high-quality diets are cross-sectionally associated with lower fatigue, depression, and disability (11), we assess whether level of adherence impacts health outcomes. We compare non-adherence to partial-and ongoingadherence, to gain insights into potential health benefits, and whether these are sustained upon cessation of diet, or whether they are beneficial with later commencement.…”

Section: Introductionmentioning

confidence: 99%

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Self-reported ongoing adherence to diet is associated with lower depression, fatigue, and disability, in people with multiple sclerosis

Jelinek

Simpson‐Yap

et al. 2023

Front. Nutr.

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IntroductionIncreasingly, dietary improvements have been shown to have positive associations with health outcomes in people with multiple sclerosis (pwMS). However, adhering to a MS-specific or high-quality diet may be a challenge. We therefore assessed the level of diet-adherence necessary to improve health outcomes of depression, fatigue, and disability.MethodsData from an international population of pwMS followed over 7.5 years (n = 671) were analyzed. Self-reported diet quality via diet habits questionnaire (DHQ), and adherence to six MS-diets [Ashton Embry Best Bet, McDougall, Overcoming MS (OMS), Paleolithic (Paleo), Swank, and Wahls] were queried at two timepoints. Four levels of diet adherence were assessed: non-adherence at either timepoint; ceased at second timepoint; commenced at second timepoint; and ongoing at both timepoints. Associations between adherence to OMS and high-quality diet (DHQ score > median) with depression, fatigue, and disability, were assessed by log-binomial regression models adjusted for confounders.ResultsForty-two percent of pwMS reported ongoing-adherence to a MS-diet at both timepoints, OMS (33%), Swank (4%), Wahls (1.5%), other (<1%). Of these, only OMS-diet adherence was analyzed for associations due to data availability. Ongoing-adherence to the OMS-diet or a high-quality diet, was associated with lower depression compared to non-adherence [OMS: Risk ratios (RR) = 0.80, p = 0.021; DHQ: RR = 0.78, p = 0.009] and ceased-adherence (OMS: RR = 0.70, p = 0.008; DHQ: RR = 0.70, p = 0.010), respectively. Ongoing-adherence to OMS-diet was associated with lower fatigue (RR = 0.71, p = 0.031) and lower severe disability (RR = 0.43, p = 0.033) compared to ceased-adherence.ConclusionResults suggest potential benefits of adherence to the OMS- or a high-quality diet on MS health outcomes, with ongoing-adherence likely best. Diet modification and maintenance may serve as a point of intervention to manage MS symptoms, especially depression, in pwMS.

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Exploring the socio-ecological factors impacting lifestyle management of multiple sclerosis: A scoping review

Manche,

Probst

2023

Multiple Sclerosis and Related Disorders

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Sociodemographic and clinical characteristics of diet adherence and relationship with diet quality in an international cohort of people with multiple sclerosis

Cited by 9 publications

References 34 publications

Berlin Registry of Neuroimmunological entities (BERLimmun): protocol of a prospective observational study

Berlin Registry of Neuroimmunological entities (BERLimmun): protocol of a prospective observational study

Self-reported ongoing adherence to diet is associated with lower depression, fatigue, and disability, in people with multiple sclerosis

Exploring the socio-ecological factors impacting lifestyle management of multiple sclerosis: A scoping review

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