Sociodemographic and psychological variables influencing adherence to antiretroviral therapy

Gordillo, Victoria Castro; Amo, Julia del; Soriano, Vincent; González-Lahoz, Juan

doi:10.1097/00002030-199909100-00021

Cited by 568 publications

(418 citation statements)

References 30 publications

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“…In the present study, adequate adherence was considered to be the use of at least 90% of the prescribed medications 10,17 , taking into account the previous five days as a proxy of habitual behavior. The frequency of non-adherence was 25.73%, similar to the figure found in a study conducted in 60 outpatients services located in seven states of Brazil 25 .…”

Section: Discussionmentioning

confidence: 99%

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Risk-factors for non-adherence to antiretroviral therapy

Silva

Ximenes

Filho

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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SUMMARYCross-sectional study analyzed as case-control to identify risk factors for non-adherence to antiretroviral therapy. We studied 412 out-clinics HIV infected subjects of three public hospitals of Recife, Pernambuco. The objective was to examine the association between non-adherence to the antiretroviral therapy and biological, social-behavior and demographics and economic factors, factors related to the disease and/or treatment, factors related to life habits and depression symptoms. Variables significantly associated with non-adherence to antiretroviral therapy were: time elapsed since HIV diagnosis (p = 0.002), daily dose (p = 0.046), use of alcohol (p = 0.030) and past drug use (p = 0.048), and borderline p-values were found for educational level (p = 0.093) and family monthly income (p = 0.08). In the multivariable analysis, the factors that remained in the final model were family monthly income, time period with HIV infection and use of alcohol. No association was observed between non-adherence to antiretroviral therapy and gender, age, sexual orientation, marital status, educational level and place of residence.Based on our results and the local situation we suggest: assessment of social needs; training of partners and/or families on supporting adherence, creation of "adherence groups" to motivate and to reassure patients on the benefits of treatment; counseling and/or psychotherapy for alcohol drinkers.

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Section: Discussionmentioning

confidence: 99%

“…To calculate the sample size, the frequency of exposure was based on two variables studied by GORDILLO et al 10 . The sample size estimated was 352 patients for the mode of HIV transmission variable and 372 for the current work situation variable.…”

Section: Methodsmentioning

confidence: 99%

Risk-factors for non-adherence to antiretroviral therapy

Silva

Ximenes

Filho

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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“…The data collection considered participants who missed at least one dose in the past month as being non-adherent to ART [30,31]. …”

Section: Methodsmentioning

confidence: 99%

“…Additionally, multiple linear regressions examined the association between harmful alcohol drinking and the quality of life (QOL) domains. In each model, important covariates such as age, education, marital status, occupation, physical symptoms, and HIV-clinical staging were adjusted, as studies have indicated that these factors can influence ART adherence [30,31]. All data were analyzed using STATA version 12.1.…”

Section: Methodsmentioning

confidence: 99%

Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life

Pokhrel

Pokhrel²,

Neupane³

et al. 2018

Global Health Action

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Background: People living with Human Immunodeficiency Virus (HIV) often suffer from alcohol-use disorders resulting in their poor health and treatment outcomes. Little is known about the association of harmful alcohol drinking with their adherence to anti-retroviral therapy (ART) and health-related quality of life (QOL) in low-resource settings. Objective: This study aimed to investigate associations between harmful alcohol drinking, adherence to ART and health-related QOL in HIV-positive people, stratified by gender, in Nepal. Methods: We conducted a cross-sectional study of 682 HIV-positive people on ART to measure their self-reported harmful alcohol drinking and non-adherence to ART in the previous month of data collection. We also measured health-related QOL using a WHOQOL-HIV BREF scale. The association between harmful alcohol drinking and non-adherence to ART was examined using multiple logistic regressions. Additionally, multiple linear regressions examined association between harmful alcohol drinking and QOL. Results: Harmful alcohol drinking was associated with non-adherence to ART among men (AOR: 2.48, 95% CI: 1.50, 4.11, p < 0.001) and women (AOR: 2.52, 95% CI: 1.32, 4.80, p = 0.005). Men were more likely to have lower score for the psychological (β = −0.55, p = 0.021) and level of independence (β = −0.68, p = 0.018) domains when they had harmful alcohol drinking. Moreover, women were more likely to have lower scores for the physical (β = −1.01, p = 0.015), social relations (β = −0.82, p = 0.033), environmental (β = −0.88, p = 0.011), and spiritual (β = −1.30, p = 0.005) domains of QOL when they had harmful alcohol drinking. Conclusions: Harmful alcohol drinking had a negative association with ART adherence and QOL in both HIV-positive men and women in Nepal. Screening for alcohol-use disorders and community-based counseling services should be provided while delivering ART services to improve treatment adherence and QOL.

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“…Many of the behavioral consequences of depression among patients with HIV/AIDS have significant health implications, including problems adhering to antiviral regimens [8][9][10]. Across a range of settings and populations, depression has been associated with reduced probability of antiretroviral utilization [11,12].…”

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confidence: 99%