Sociodemographic factors associated with Mohs micrographic surgery versus wide local excision in pediatric dermatofibrosarcoma protuberans

Brown-Korsah, Jessica; Hill, Sheena T.; Bordeaux, Jeremy S.

doi:10.1016/j.jaad.2022.06.1179

Cited by 1 publication

(3 citation statements)

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“…DFSP cases are usually an unexpected pathological result of a presumably benign skin mass. Thus, it can be challenging when a safe margin was ignored in such patients [2,5,15,17,23]. Such conditions can result in a 3-to 5-year delay in diagnosis of patients with cases suspicious for DFSP [13].…”

Section: Diagnosismentioning

confidence: 99%

“…Some studies have suggested the use of traditional post-op radiotherapy since DFSP is known to be radiosensitive. In fact, radiotherapy can be life-saving in tumors with questionable margins or inoperable lesions to reduce the morbidity, distant metastasis, and need for extensive reoperation [15,16]. Regarding immunotherapy, in addition to imatinib, sorafenib is successful in the treatment of angiosarcomas.…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

“…Mohs micrographic surgery (MMS) and wide local excision (WLE) are surgical options for the treatment of DFSP. However, there are conflicting results in terms of choosing the most suitable type of surgical treatment for DFSP patients [3,8,[10][11][12][13][14][15]. In the following study, we report our own experience of diagnosis and treatment of six cases of DFSP and review recent updates in the journey toward finding the best treatment for patients with DFSP.…”

Section: Introductionmentioning

confidence: 99%

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Dermatofibrosarcoma protuberans challenges: a case series and review of the literature

et al. 2023

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Background Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised. Case presentation Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgical excision was performed for all these patients and no extra treatment was considered. Samples were studied by hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) tests. Only one of our patients experienced recurrence after the initial surgery. Conclusion Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commonly known as a malignant skin lesion, delay in treatment will have a catastrophic impact on patients’ lives. Thus, applying an in-time surgical method (wide local excision in our cases) in treating DFSP is crucial in preventing recurrence as well as decreasing the morbidity burden of DFSP.

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