Sociodemographic, Family History, and Lifestyle Risk Factors for Open-angle Glaucoma and Ocular Hypertension

Doshi, Vatsal; Ying-Lai, Mei; Azen, Stanley P.; Varma, Rohit

doi:10.1016/j.ophtha.2007.05.032

Cited by 105 publications

(95 citation statements)

References 40 publications

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“…The LALES finding of a positive association between male sex and glaucoma (adjusted OR 1.64, 95% CI 1.23-2.2) is consistent with the results of the Barbados study [17] (male vs. female OR 1.66, 95% CI 1.24-2.24) [9 ].…”

Section: Male Sexsupporting

confidence: 84%

“…We found a history of glaucoma among siblings to be a stronger and more significant risk factor than a similar Analogous to a dose-response relationship, we found the association between OAG and a sibling history of glaucoma to be even greater in those who reported two siblings with glaucoma compared with those who reported only one sibling with glaucoma (OR 5.64, 95% CI 1.63-19.48 vs. OR 3.08, 95% CI 1.57-6.04) [9 ]. There is also an association between a positive family history of glaucoma and an increased risk of OHT with an adjusted OR of 1.92, 95% (CI 1.25-2.94) among the LALES participants.…”

Section: Family Historymentioning

confidence: 53%

“…Although the association between unmarried status and OAG may be small given a CI value close to the null point (OR 1.39, 95% CI 1.03-1.87), it nonetheless remained a significant risk factor in our data [9 ].…”

Section: Unmarried Statusmentioning

confidence: 56%

“…The risk of glaucoma in our Latino population increases in a linear fashion for each decade, with a 20-fold greater risk in those 80 years or older compared with those in the 40-49-year age group [4,9 ]. There is also a slow rise in IOP with age.…”

Section: Agementioning

confidence: 99%

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Glaucoma in Latinos/Hispanics

Kim

Varma

2010

Current Opinion in Ophthalmology

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Section: Male Sexsupporting

confidence: 84%

Section: Family Historymentioning

confidence: 53%

Section: Unmarried Statusmentioning

confidence: 56%

Section: Agementioning

confidence: 99%

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Glaucoma in Latinos/Hispanics

Kim

Varma

2010

Current Opinion in Ophthalmology

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“…According to several population-based studies, first-degree relatives of POAG patients have a two-to fourfold increased relative risk of developing POAG when compared with the general population. [5][6][7] The Glaucoma Inheritance Study in Tasmania revealed that POAG is familial for B60% of patients and that the disease is more severe in patients with a family history than those without it. 8 Further, 21 POAG susceptibility loci have been identified by linkage studies, including 14 assigned as GLC1A-GLC1N and 10 that remain unassigned.…”

Section: Introductionmentioning

confidence: 99%

Expansive marker analysis replicating the association of glaucoma susceptibility with human chromosome loci 1q43 and 10p12.31

et al. 2013

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Three human chromosome loci (1q43, 10p12.31, and 12q21.31) were recently associated with the susceptibility to primary open-angle glaucoma (POAG) in a Japanese population; however, this was not replicated in three subsequent studies using South Indian, Afro-Caribbean, and Chinese populations. To identify genetic markers that are robustly associated across ethnic populations, numerous markers in addition to the six in the three reported loci were examined in this study. A total of 31 single-nucleotide polymorphism (SNP) markers were genotyped for 1115 Korean participants, and many neighboring SNPs were imputed using the Korean HapMap Project genotype data. Each SNP was statistically tested for association with POAG susceptibility by comparisons among 211 POAG patients with 904 unaffected controls. A strong and statistically significant association was found with a previously unreported SNP, rs7098387 (odds ratio, OR ¼ 2.0 (1.4-3.0), P ¼ 0.00038) at the 10p12.31 locus (where 11 SNPs were typed and 38 imputed) in contrast to the reported rs7081455, which was too poorly correlated with newly associated rs7098387 (r 2 ¼ 0.003, D 0 ¼ 0.40) to show association. Additionally, a modest association was observed with the reported rs693421 (OR ¼ 1.4 (1.1-1.7), P ¼ 0.0082) and several other SNPs located within and around ZP4 at the 1q43 locus (10 SNPs typed and 14 imputed). However, no association was observed with the reported rs7961953 SNP or any other SNPs at the 12q21.31 locus, upstream of TMTC2 (10 SNPs typed and 29 imputed). Accordingly, POAG susceptibility association was replicated using rs7098387 (C) rather than rs7081455 (T) at the 10p12.31 locus and additionally with rs693421 (T) at the 1q43 locus.

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Lifestyle and Risk of Developing Open-Angle Glaucoma

Ramdas¹

2011

Arch Ophthalmol

116

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Methods: Participants from the Rotterdam Study, a prospective population-based cohort study, were considered eligible if they participated at both baseline and follow-up and if they had no OAG at baseline. All participants underwent an identical ophthalmologic examination at all visits, including intraocular pressure measurements, optic nerve head assessment, and perimetry. Lifestyle-related factors were assessed by questionnaires by trained research assistants or measured during the examinations (body mass index and waist to hip ratio). Cox proportional hazard regression analysis was applied to calculate hazard ratios. Results: Of 3939 eligible participants, 108 (2.7%) developed OAG during 9.7 years' mean follow-up. No statistically significant effect of socioeconomic status, smoking, or alcohol intake was found. In women, each unit increase in body mass index resulted in a 7% decrease in the risk of developing OAG (P =.04). There was a significant increasing effect of body mass index on intraocular pressure (P Ͻ.001) in women. Conclusions: Obesity appears to be associated with a higher intraocular pressure and a lower risk of developing OAG. These associations were only present in women. Other lifestyle-related factors, such as socioeconomic status, smoking, and alcohol consumption, were not associated with OAG.

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Sociodemographic, Family History, and Lifestyle Risk Factors for Open-angle Glaucoma and Ocular Hypertension

Cited by 105 publications

References 40 publications

Glaucoma in Latinos/Hispanics

Glaucoma in Latinos/Hispanics

Expansive marker analysis replicating the association of glaucoma susceptibility with human chromosome loci 1q43 and 10p12.31

Lifestyle and Risk of Developing Open-Angle Glaucoma

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