Sociodemographic features and outcomes of peritonitis episodes in children on peritoneal dialysis

Pınarbaşı, Ayşe Seda; Kara, Mehtap

doi:10.1111/1744-9987.13836

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Peritonitis is one of the major complications of peritoneal dialysis. It remains the primary reason for switching from peritoneal dialysis to hemodialysis [13][14][15]. One of the significant results in peritonitis is damage to the peritoneal membrane.…”

Section: Discussionmentioning

confidence: 99%

High C‐reactive protein and number of previous episodes at diagnosis increase the risk of catheter removal in peritoneal dialysis‐related peritonitis in children

Gözmen

Serdaroğlu

2022

Ther Apher Dial

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Background A minority of patients with peritonitis require removal of peritoneal dialysis (PD) catheters. We examined risk factors at diagnosis that could predict the removal of PD catheter before obtaining the results of treatment success in children with peritonitis. Methods We analyzed 156 peritonitis episodes in 57 pediatric PD patients. Results The peritonitis rate was 0.68 peritonitis episode per patient year. Catheter removal was required in 22 of 156. C‐reactive protein (CRP) ≥ ×10 of upper limit at diagnosis and increased previous episode number were found to be associated with catheter removal (OR [95% CI] 6.4 [2.3–18.1], p = 0.001 and 3.8 [1.4–10.6], p = 0.009). Conclusion These findings supported that CRP could be an early marker in predicting catheter removal even before obtaining the results of treatment success. Furthermore, it should be kept in mind that the risk of catheter removal is high in patients with high number of previous episodes especially of three or more.

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Section: Discussionmentioning

confidence: 99%

High C‐reactive protein and number of previous episodes at diagnosis increase the risk of catheter removal in peritoneal dialysis‐related peritonitis in children

Gözmen

Serdaroğlu

2022

Ther Apher Dial

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Hepatic Toxicity Assessment in HIV’s Interaction with Reverse Transcriptase and Integrase Strand Transfer Inhibitors at a Military Hospital, Southsouth Nigeria

Odegbemi,

Olaniyan,

Muhibi

2024

Preprint

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Anti-retroviral therapy (ART) use has made HIV a manageable condition, but there are risks associated with medications like Reverse Transcriptase Inhibitors (RTIs) and Integrase Strand Transfer Inhibitors (INSTIs), such as liver and renal toxicity. It is essential to understand these risks for effective treatment. Investigating liver toxicity related to RTIs and INSTIs in Nigeria is crucial for optimizing HIV treatment. This study aimed to assess the impact of Tenofovir Lamivudine Dolutegravir (TLD) on the liver function of HIV-patients at Nigerian Navy Hospital (NNH) Warri. Liver function of 170 participants was assessed, with 120 on ART and the remainder being HIV-negative attendees at NNH Warri. The study used a cross-sectional design and selected participants through simple random sampling. We collected data using semi-structured questionnaire. Blood samples were taken through venipuncture and stored at -20oC before analysis. Ethical approval was obtained, and data analysis was conducted using SPSS Statistical Software, with significance set at p < 0.05. The study found significant differences in AST, TP, Alb, and GST levels between HIV-positive subjects receiving TLD and HIV-negative individuals. HIV-positive subjects had lower AST and Alb levels but higher TP and GST levels. Further analysis revealed correlations between age, gender, and liver enzymes, highlighting the complex relationship between HIV, liver function, and treatment outcomes. The study suggests that decreased AST levels may have a protective effect, while ALT activity had minimal impact. Changes in TP, Alb, and GSTs emphasize the importance of monitoring hepatic synthetic function and detoxification pathways in HIV patients taking TLD.

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Hepatic toxicity assessment in HIV’s interaction with reverse transcriptase and integrase strand transfer inhibitors at a military hospital, southsouth Nigeria

Odegbemi,

Olaniyan,

Muhibi

2024

Egypt Liver Journal

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Introduction The use of anti-retroviral therapy (ART) has made HIV a manageable condition, but there are risks associated with medications like reverse transcriptase inhibitors (RTIs) and integrase strand transfer inhibitors (INSTIs), such as liver and renal toxicity. It is essential to understand these risks for effective treatment and case management. Investigating liver toxicity related to RTIs and INSTIs in Nigeria is crucial for optimizing HIV treatment. This study aimed to assess the impact of tenofovir lamivudine dolutegravir (TLD) on the liver function of HIV patients at Nigerian Navy Hospital (NNH)-Warri. Methods The liver function of 170 participants was assessed, with 120 on ART and the remainder being HIV-negative attendees at NNH-Warri. The study used a cross-sectional design and selected participants through random sampling. We collected data using a semi-structured questionnaire. Blood samples were taken through venipuncture and stored at – 20 °C before analysis. Ethical approval was obtained, and data analysis was conducted using SPSS Statistical Software Version 23, with significance set at p < 0.05. Results The study found significant differences in AST, TP, Alb, and GST levels between HIV-positive subjects receiving TLD and HIV-negative individuals. HIV-positive subjects had lower AST and Alb levels but higher TP and GST levels. Further analysis revealed correlations between age, gender, and liver enzymes, highlighting the complex relationship between HIV, liver function, and treatment outcomes. Conclusion The study suggests that decreased AST levels may have a protective effect, while ALT activity had minimal impact. Changes in TP, Alb, and GSTs emphasize the importance of monitoring hepatic synthetic function and detoxification pathways in HIV patients taking TLD.

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Sociodemographic features and outcomes of peritonitis episodes in children on peritoneal dialysis

Cited by 3 publications

References 22 publications

High C‐reactive protein and number of previous episodes at diagnosis increase the risk of catheter removal in peritoneal dialysis‐related peritonitis in children

High C‐reactive protein and number of previous episodes at diagnosis increase the risk of catheter removal in peritoneal dialysis‐related peritonitis in children

Hepatic Toxicity Assessment in HIV’s Interaction with Reverse Transcriptase and Integrase Strand Transfer Inhibitors at a Military Hospital, Southsouth Nigeria

Hepatic toxicity assessment in HIV’s interaction with reverse transcriptase and integrase strand transfer inhibitors at a military hospital, southsouth Nigeria

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