Sociodemographic Predictors of Clinical Effectiveness, Therapeutic Program Engagement, and Device Usability for an In-Home Virtual Reality Program for Chronic Low Back Pain: Secondary Analysis of a Randomized Controlled Trial

Redesigning Pharmacy to Improve Public Health Outcomes: Expanding Retail Spaces for Digital Therapeutics to Replace Consumer Products That Increase Mortality and Morbidity Risks

“…PDT, prescription digital therapeutic; OTC, over-the-counter; AI, artificial intelligence. Products Type of Product Healthcare Outcomes References RelieVRx FDA-cleared virtual reality system as PDT intended for treatment of chronic low back pain Long-term, non-opioid pain reduction in adults with moderate to severe chronic low back pain [ 39 , 55 , 56 , 57 ] Welldoc App, BlueStar FDA-cleared PDT and OTC DTx mobile apps that provide support and digital coaching for patients with diabetes, prediabetes, heart failure, and hypertension Diabetic patients experienced a statistically significant improvement in hemoglobin A1c levels [ 58 , 59 ] EndeavorOTC, EndeavorRx OTC DTx and PDT mobile game designed to treat and improve attention deficit hyperactivity disorder (ADHD) symptoms in children and adults using a series of video games Improvements in attention, multi-tasking, and cognitive function for adults with ADHD. PDT version was also effective for pediatric ADHD [ 41 , 60 , 61 ] Daylight by Big Health CBT-based mobile app marketed for generalized anxiety disorder under the FDA enforcement discretion Long-lasting improvement of generalized anxiety [ 62 , 63 ] Sleepio Digital CBTi intervention for insomnia marketed under FDA enforcement discretion Improves irregular sleeping patterns.…”