Socioeconomic and administrative factors associated with treatment delay of esophageal and gastric carcinoma: Prospective study from a tertiary care centre in a developing country

Dasappa, Lokanatha; Hassan, Syed Adil; Jacob, Linu Abraham; Babu, M C Suresh; Lokesh, K N; Rudresha, A H; Rajeev, L K; Smitha, S.; Thottian, Antony George Francis

doi:10.1016/j.canep.2020.101770

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…The clinical stage at presentation was recorded in 196 and 25 patients with SCC and AC, respectively. Similar to most studies in other low-income countries, most patients presented with advanced disease belonging to either stage III or IV (15). A total of 119 patients had distant metastases to the liver 44 (19.1%), lung 34 (14.8%), celiac lymph nodes 24 (10.4%), peritoneum 7 (3%), supraclavicular lymph node 4 (1.7%), vertebrae or bone 5 (2.2%) or brain 1 (0.4%).…”

Section: Discussionsupporting

confidence: 85%

“…The clinical stage at presentation was recorded in 196 and 25 patients with SCC and AC, respectively. Similar to most studies in other low-income countries, most patients presented with advanced disease belonging to either stage III or IV (15) Definitive surgery, neoadjuvant chemoradiotherapy followed by surgery and adjuvant chemotherapy, and concurrent chemoradiotherapy are recommended options for the treatment of esophageal cancer, depending on the stage at presentation and the site of the lesion (5,16).…”

Section: Discussionmentioning

confidence: 64%

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Clinical feature, treatment pattern and survival of Esophageal cancer at Tikur Anbessa Specialized Hospital, Ethiopia: a prospective cohort study

Feyisa

Adissie

Kantelhardt

et al. 2023

Preprint

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Purpose Ethiopia is located within the esophageal belt of Africa. Esophageal cancer is the seventh leading cause of death in Ethiopia. There is a paucity of literature regarding the clinical features, treatment patterns, and survival of patients with esophageal cancer. We report the clinical profile, treatment pattern, and survival of patients with esophageal cancer at Tikur Anbessa Specialized Hospital, Ethiopia. Methods An unmatched prospective cohort study was conducted from February 27, 2018 to February 28, 2020. We used the Kaplan–Meier method to assess the overall survival time and survival time according to stage and treatment type. Multivariate Cox regression analysis with the backward LR selection method was used to fit the final model. Result In total, 230 patients with esophageal cancer were recruited for this study. The median survival time was six months (95%CI) (5, 7). A total of 170 (73.9%) patients died during the 1,244 person-month follow-up period, resulting in an overall event rate of 162 per 1,000 person–months. The overall survival rate was very low with 6 months, 1-, and 2-year survival rates of 54.6% (95%CI:47.5%-61.2%), 19.5% (13.8% -25.9%), and 2.0% (0.45%–5.9%), respectively. Chemotherapy, local recurrence, and brain metastases were variables that explained the model. Conclusion survival of patients with esophageal cancer at Tikur Anbessa Specialized Hospital was very short. We recommend multimodal treatment to improve treatment outcomes.

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Section: Discussionsupporting

confidence: 85%

“…The clinical stage at presentation was recorded in 196 and 25 patients with SCC and AC, respectively. Similar to most studies in other low-income countries, most patients presented with advanced disease belonging to either stage III or IV (15) Definitive surgery, neoadjuvant chemoradiotherapy followed by surgery and adjuvant chemotherapy, and concurrent chemoradiotherapy are recommended options for the treatment of esophageal cancer, depending on the stage at presentation and the site of the lesion (5,16).…”

Section: Discussionmentioning

confidence: 64%

Clinical feature, treatment pattern and survival of Esophageal cancer at Tikur Anbessa Specialized Hospital, Ethiopia: a prospective cohort study

Feyisa

Adissie

Kantelhardt

et al. 2023

Preprint

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“…This study found that the risk of patients over 59 years of age increased with age. Due to the patient and hospital factors and other factors, the interval between making a de nite diagnosis of cancer and treatment may be prolonged [21] . The impact of a delayed treatment on the survival of cancer patients is controversial.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of gastric malignancies based on the SEER database

Han

Liu

Zhang

et al. 2023

Preprint

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Introduction: Gastric malignancies are common worldwide, with a high incidence rate and mortality. Relevant studies are needed to further demonstrate the harmfulness of gastric malignancies to improve the awareness of its prevention. Methods: The SEER database was used to obtain the clinical data of 122793 patients diagnosed with gastric malignancies from 2000 to 2019. Along with performing univariate and multivariate analyses, the associated survival rates of each variable were analyzed using SPSS software. Columnar line graph prediction models were developed and validated using R software. Results: In total, 122793 gastric malignancy patients were included in this study, including 74303 males(60.51%) and 48490 females(39.49%). Most patients were aged 60-74 years old: 45603 patients(37.14%). The follow-up time was 0-239 months, the median follow-up time was 11 months, and 91869 patients(74.82%) died. Gastric adenocarcinoma was the main pathological type: 96259 patients(78.39%). The main disease site was the cardia of the stomach: 34019 patients(27.70%); Most patients lived in cities: 109706 patients(89.34%). Univariate and multivariate analysis showed that gender, age, tumor size, tumor location, AJCC stage, pathological type, rural/urban, and treatment were independent risk factors for prognosis(P<0.05). The C-index of the nomogram prognostic model was 0.763 ± 0.002, and the areas under the ROC curve of the 1-year, 3-year and 5-year survival rates were 0.76, 0.79 and 0.79,respectively. The calibration curve showed that the predicted survival rate of the nomogram was in good agreement with the observed survival rate. Conclusion: The prognosis of tumors located in the greater curvature of the stomach is relatively good. The patient’s city level is proportional to the prognosis. The prognosis of gastric stromal tumors and gastric neuroendocrine neoplasms is significantly better than that of the other pathological types. The patients who reach the surgical indication should have surgery as early as possible to prolong the survival time.

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“…Socio-economic differences may indicate health system structural inequities and/or access barriers. Additionally, persons living in materially deprived areas are more likely to have jobs that do not allow them to take time off work and face other personal barriers to seeking health care [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Time to Surgery for Patients with Esophageal Cancer Undergoing Trimodal Therapy in Ontario: A Population-Based Cross-Sectional Study

et al. 2022

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Patients with resectable esophageal cancer are recommended to undergo chemoradiotherapy before esophagectomy. A longer time to surgery (TTS) and/or time to consultation (TTC) may be associated with inferior cancer-related outcomes and heightened anxiety. Thoracic cancer surgery centers (TCSCs) oversee esophageal cancer management, but differences in TTC/TTS between centers have not yet been examined. This Ontario population-level study used linked administrative healthcare databases to investigate patients with esophageal cancer between 2013–2018, who underwent neoadjuvant chemoradiotherapy and then surgery. TTC and TTS were time from diagnosis to the first surgical consultation and then to surgery, respectively. Patients were assigned a TCSC based on the location of the surgery. Patient, disease, and diagnosing physician characteristics were investigated. Quantile regression was used to model TTS/TTC at the 50th and 90th percentiles and identify associated factors. The median TTS and TTC were 130 and 29 days, respectively. The adjusted differences between the TCSCs with the longest and shortest median TTS and TTC were 32 and 18 days, respectively. Increasing age was associated with a 16-day longer median TTS. Increasing material deprivation was associated with a 6-day longer median TTC. Significant geographic variability exists in TTS and TTC. Therefore, the investigation of TCSC characteristics is warranted. Shortening wait times may reduce patient anxiety and improve the control of esophageal cancer.

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Socioeconomic and administrative factors associated with treatment delay of esophageal and gastric carcinoma: Prospective study from a tertiary care centre in a developing country

Cited by 7 publications

References 20 publications

Clinical feature, treatment pattern and survival of Esophageal cancer at Tikur Anbessa Specialized Hospital, Ethiopia: a prospective cohort study

Clinical feature, treatment pattern and survival of Esophageal cancer at Tikur Anbessa Specialized Hospital, Ethiopia: a prospective cohort study

Clinicopathological characteristics and prognosis of gastric malignancies based on the SEER database

Time to Surgery for Patients with Esophageal Cancer Undergoing Trimodal Therapy in Ontario: A Population-Based Cross-Sectional Study

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