Socioeconomic burden of foodborne parasites

Conlan, James V.; Lal, Aparna

doi:10.1016/b978-1-78242-332-4.00005-9

Cited by 3 publications

(1 citation statement)

References 117 publications

(153 reference statements)

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“…Many patients remain asymptomatic or are only transiently afflicted causing underreporting of the true prevalence. Symptomatic patients contribute to the estimated 89.5 million disability-adjusted-life-years lost world-wide due to diarrheal disease (Conlan and Lal 2015 ; Murray et al 2012 ). However, correlations between socioeconomic factors such as lack of plumbing and an increased risk of infection may explain why giardiasis has a higher prevalence in lower-income countries (Silva et al 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Climate and Livestock Reservoirs on Human Cases of Giardiasis

et al. 2018

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Giardia duodenalis is an intestinal parasite which causes diarrhoeal illness in people. Zoonotic subtypes found in livestock may contribute to human disease occurrence through runoff of manure into multi-use surface water. This study investigated temporal associations among selected environmental variables and G. duodenalis occurrence in livestock reservoirs on human giardiasis incidence using data collected in the Waterloo Health Region, Ontario, Canada. The study objectives were to: (1) evaluate associations between human cases and environmental variables between 1 June 2006 and 31 December 2013, and (2) evaluate associations between human cases, environmental variables and livestock reservoirs using a subset of this time series, with both analyses controlling for seasonal and long-term trends. Human disease incidence exhibited a seasonal trend but no annual trend. A Poisson multivariable regression model identified an inverse association with water level lagged by 1 month (IRR = 0.10, 95% CI 0.01, 0.85, P < 0.05). Case crossover analysis found varying associations between lagged variables including livestock reservoirs (1 week), mean air temperature (3 weeks), river water level (1 week) and flow rate (1 week), and precipitation (4 weeks). This study contributes to our understanding of epidemiologic relationships influencing human giardiasis cases in Ontario, Canada.Electronic supplementary materialThe online version of this article (10.1007/s10393-018-1385-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The Influence of Climate and Livestock Reservoirs on Human Cases of Giardiasis

et al. 2018

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Identification of Phyto-Compounds from Ilex kudingcha as Inhibitors of Sterol-14α-Demethylase Protease: A Computational Approach Against Chagas Disease

et al. 2022

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Tinospora Cordifolia Bioactive Compounds as a Novel Sterol 14a- Demethylase (Cyp51) Inhibitor: an Insilico Study

Mesileya,

onyeka,

Adaramola

et al. 2024

Preprint

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Background: For both endemic and non-endemic areas, Trypanosoma cruzi is the cause of Chagas disease, which can be life-threatening. Oversight: The entire life cycle of T. cruzi relies on the natural production of sterol through the 14-α-demethylase metabolic pathway. Many of the medications now used to treat Chagas disease have undesirable side effects and are resistant to treatment. Using bioactive chemicals from Tinospora cordifolia, this study attempted to anticipate the inhibitor(s) of sterol 14a-demethylase (cyp51). Utilizing the glide model, a library including one hundred twenty-two (122) compounds from Tinospora cordifoliawas screened against sterol 14-α-demethylase (cyp51). The e-pharmacophore, pharmacokinetics profile and generalized born surface area (mm-gbsa) in molecular mechanics were performed utilizing four (4) leads and the maestro-schrodinger suite (2022). Results: The results indicate that the top four compounds outperform the standard drug (benznidazole). In binding affinity to 14-α-demethylase, as evidenced by docking scores ranging from -11.397 kcal/mol to -9.539 kcal/mol. Furthermore, the top compounds did not appear to be cytotoxic by ADMET projections. The hit compounds' density functional theory results showed that their Ehomo values ranged from -5.59 eV to -5.80 eV, indicating that the hit molecules are electron donors. Conclusions: This study identifies potential Tinospora cordifolia inhibitors with higher binding affinities and provides a detailed description of their interaction with the target protein. Although the results are favorable, further in vivo and in vitro studies are required to confirm these compounds' potential as anti-Chagas agents.

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Socioeconomic burden of foodborne parasites

Cited by 3 publications

References 117 publications

The Influence of Climate and Livestock Reservoirs on Human Cases of Giardiasis

The Influence of Climate and Livestock Reservoirs on Human Cases of Giardiasis

Identification of Phyto-Compounds from Ilex kudingcha as Inhibitors of Sterol-14α-Demethylase Protease: A Computational Approach Against Chagas Disease

Tinospora Cordifolia Bioactive Compounds as a Novel Sterol 14a- Demethylase (Cyp51) Inhibitor: an Insilico Study

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