Background: Cancer poses significant challenges beyond its physical manifestations, impacting the psychosocial dimensions of patients and their caregivers. Understanding these complexities is crucial for delivering effective care. This study aims to explore the perceptions of cancer patients and their caregivers in Lubumbashi, Democratic Republic of Congo (DRC). Methods: A descriptive cross-sectional study was conducted from November 2016 to July 2017, involving female cancer patients and their caregivers from major hospitals in Lubumbashi. Data were collected using standardized questionnaires and analyzed quantitatively. Results: The majority of cancer patients were aged ≥45 years (88.9%), married (63.0%), and illiterate (44.4%). Cervical cancer (48.1%) was most prevalent, with late-stage diagnoses predominating. Only 22.2% of patients were informed of their diagnosis by a doctor. Palliative care was common (63.0%), reflecting advanced disease presentation. Caregivers reported significant financial challenges (92.6%) and anxiety (96.3%), suggesting unmet support needs. Conclusion: This study underscores the urgent need for improved cancer awareness, early detection, and psychosocial support services in Lubumbashi. Addressing the cultural, educational, and economic barriers to cancer care is essential for enhancing patient outcomes and caregiver well-being in the DRC.