Background: Burns in children are a massive problem in Egypt. Nowadays, infections account for 51% of the overall fatalities and are the second leading cause of mortality and morbidity after burn injuries. Aim: to identify risk factors associated with wound infection in burned children. Methods: An exploratory descriptive research design was adopted for this study. At the burn and plastic surgery center of El-Mansoura University Hospitals, this study was conducted. Based on specific inclusion criteria, a purposive sample of 75 hospitalized burned children and a convenient sample of 30 nurses participated. Three main tool parts were utilized. Part I: Questionnaire Sheet: Personal information regarding burned children and personal information about nurses who care for hospitalized burned children. Part II: Health Profile Assessment Sheet covered information about a hospitalized burned child. Part III: Checklist of Observations was adapted from the Egyptian Ministry of Health's Infection Control Checklist. Results: The mean age of the burned children was 3.94 ±1.66 years. Two-thirds of the children were male. Pseudomonas infections cause about half of all burn infections. There was a statistically significant relationship between the nurses' practice score and the burn characteristics of burned children three days after admission to the unit. The nurses' practice scores and the length of time that children stay in hospitals were statistically related. Conclusion: Poor hand hygiene was the most significant contributing factor in acquiring infections, as was a lack of adherence to the wearing of Personal Protective Equipment (PPE) and contact isolation precautions not carried out.