Stroke is a major public health problem as the population is ageing in the world. During the past 2 decades, the burden of stroke has increased from the fifth rank to the third, 1 and stroke remains the second cause of death.2 There is evidence that people with socioeconomic deprivation (SED) have an increased incidence of stroke and a higher mortality after stroke. 3,4 However, it is unclear whether SED is associated with functional impairment after stroke. Previous studies examining the association were of small sample size and had insufficient adjustment for potential confounders, showing conflicting findings. [5][6][7][8] There is a lack of data on the SED effect on long-term functional impairment after stroke. Although it is known that older or female patients are more likely to have SED and functional impairment after stroke in comparison with their counterparts, 8 it is unclear whether the effect of SED on functional recovery after stroke differs by age and sex. Recent data 9 showed that in patients with stroke, the prevalence of prestroke comorbidities, such as atrial fibrillation, has decreased during the past 2 decades. It is unknown whether the effect of SED on functional recovery after stroke is different among patients with and without these comorbidities. Although the number of patients with primary hemorrhagic stroke is increasing globally, no study has examined the association of SED with functional impairment after hemorrhagic stroke. In this study, we investigated the effect of SED on functional impairment after stroke in a long-term follow-up of population-based stroke register. We examined differences in the effect in terms of patients' age, sex, prestroke comorbidities, and stroke subtypes.Background and Purpose-Previous findings of the association between socioeconomic deprivation and functional impairment after stroke are inconsistent. There is a lack of data on long-term association. We assessed the association and differences by age, sex, prestroke comorbidities, and stroke phenotypes. Methods-We examined data from the South London Stroke Register cohort of 1995 to 2011, recording all first-ever strokes in patients of all ages in South London. A total of 2104 patients were alive at 3 months after stroke. Socioeconomic deprivation was measured using the index of multiple deprivation based on patient postcodes, and functional impairment after stroke was defined as a Barthel index of <15. Results-At 3 months after stroke, 643 patients had functional impairment (30.6%; 95% confidence interval, 28.6%-32.5%).Compared with the first quartile of index of multiple deprivation (the least deprived), multivariate-adjusted odds ratios for functional impairment in patients with the second, third, and fourth quartiles were 1.
Methods
Data CollectionThe study population was derived from the South London Stroke Register (SLSR). 10 The SLSR methodology has been fully described before. 10,11 In brief, the SLSR is an ongoing prospective populationbased stroke register set up in January 1995, recording all ...