Background: Disparities exist in access to living donor liver transplantation (LDLT) in the United States. However, the association of neighborhood-level social determinants of health (SDoH) on the receipt of LDLT is not well-established. Methods: This was a retrospective cohort study of adult liver transplant recipients between 01/01/2005 and 12/31/2021 at centers performing LDLT using the United Network for Organ Sharing (UNOS) database, which was linked via patients’ ZIP code to a set of 24 neighborhood-level SDoH measures from different data sources. Temporal trends and center differences in neighborhood Social Deprivation Index (SDI), a validated scale of socioeconomic deprivation ranging from 0-100 (0=least disadvantaged), were assessed by transplant type. Multivariable logistic regression evaluated the association of increasing SDI on receipt of LDLT (vs. DDLT). Results: There were 51,721 DDLT and 4,026 LDLT recipients at 59 LDLT-performing centers during the study period. Of the 24 neighborhood-level SDoH measures studied, the SDI was most different between the two transplant types, with LDLT recipients having lower SDI (i.e., less socioeconomic disadvantage) than DDLT recipients (median SDI 37 vs. 47; p<0.001). The median difference in SDI between the LDLT and DDLT groups significantly decreased from 13 in 2005 to 3 in 2021 (p=0.003). In the final model, SDI quintile was independently associated with transplant type (p<0.001) with a threshold SDI of approximately 40, above which increasing SDI was significantly associated with a reduced odds of LDLT (vs. reference SDI 1-20). Conclusions: As a neighborhood-level SDoH measure, SDI is useful for evaluating disparities in the context of LDLT. Center outreach efforts that aim to reduce disparities in LDLT could preferentially target U.S. ZIP codes with SDI >40.